Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults
Por:
Girona M, Argüello G, Esteve-Solé A, Bobillo-Perez S, Paolo-Burgos X, Bonet E, Mensa-Vilaró A, Codina-Bergadà A, Hernández-Garcia M, Jou-Munoz C, Alsina L and Jordán-García I
Publicada:
21 ene 2022
Categoría:
Multidisciplinary
Resumen:
It is unclear why COVID-19 ranges from asymptomatic to severe. When SARS-CoV-2 is detected, interferon (IFN) response is activated. When it is insufficient or delayed, it might lead to overproduction of cytokines and severe COVID-19. The aim was to compare cytokine and IFN patterns in children and adults with differing severity with SARS-CoV-2. It was a prospective, observational study, including 84 patients. Patients with moderate/severe disease had higher cytokines' values than patients with mild disease (p< 0.001). Two IFN genes were selected to build a decision tree for severity classification: SOCS1 (representative of the rest of the IFN genes) and CIITA (inverse correlation). Low values of CIITA and high values of SOCS1 indicated severe disease. This method correctly classified 33/38(86.8%) of children and 27/34 (79.4%) of adults.
To conclude, patients with severe disease had an elevated cytokine pattern, which correlated with the IFN response, with low CIITA and high SOCS1 values.
Filiaciones:
Girona M:
Paediatric Intensive Care Unit
Hospital Sant Joan de Déu, University of Barcelona
Esplugues de Llobregat, Barcelona, 08950
Spain
Institut de Recerca Sant Joan de Déu, University of Barcelona, Esplugues de Llobregat, Barcelona, 08950
Argüello G:
Faculty of Computer Science, Multimedia and Telecommunications
Universitat Oberta de Catalunya
Barcelona, 08018
Spain
Statistics and Operations Research, Universidad de Oviedo
Oviedo, Asturias, 33003
Esteve-Solé A:
Institut de Recerca Sant Joan de Déu, University of Barcelona, Esplugues de Llobregat, Barcelona, 08950
Spain
Allergy and Clinical Immunology Department
Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, 08950
Clinical Immunology Unit
Hospital Sant Joan de Déu - Hospital Clínic de Barcelona, Esplugues de Llobregat, Barcelona, 08950
Bobillo-Perez S:
Paediatric Intensive Care Unit
Hospital Sant Joan de Déu, University of Barcelona
Esplugues de Llobregat, Barcelona, 08950
Spain
Institut de Recerca Sant Joan de Déu, University of Barcelona, Esplugues de Llobregat, Barcelona, 08950
Paolo-Burgos X:
Faculty of Computer Science, Multimedia and Telecommunications
Universitat Oberta de Catalunya
Barcelona, 08018
Spain
BCNatal | Fetal Medicine Research Center
Hospital Clínic and Hospital Sant Joan de Déu, University of Barcelona
Barcelona, 08028
Bonet E:
Faculty of Computer Science, Multimedia and Telecommunications
Universitat Oberta de Catalunya
Barcelona, 08018
Spain
BCNatal | Fetal Medicine Research Center
Hospital Clínic and Hospital Sant Joan de Déu, University of Barcelona
Barcelona, 08028
BCNatal Fetal medicine research group
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Barcelona, 08036
ETSETB
Universitat Politècnica de Catalunya • BarcelonaTech
Barcelona, 08034
Mensa-Vilaró A:
Clinical Immunology Unit
Hospital Sant Joan de Déu - Hospital Clínic de Barcelona, Esplugues de Llobregat, Barcelona, 08950
Spain
BCNatal Fetal medicine research group
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Barcelona, 08036
Codina-Bergadà A:
Pediatric Biobank Unit
Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu
Esplugues de Llobregat, Barcelona, 08950
Spain
:
Paediatric Service
Hospital Sant Joan de Déu, University of Barcelona
Esplugues de Llobregat, Barcelona, 08950
Spain
Jou-Munoz C:
Department of Pathology and Biobank
Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu
Barcelona, 08950
Spain
Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III
Madrid, 28029
Alsina L:
Institut de Recerca Sant Joan de Déu, University of Barcelona, Esplugues de Llobregat, Barcelona, 08950
Spain
Allergy and Clinical Immunology Department
Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, 08950
Clinical Immunology Unit
Hospital Sant Joan de Déu - Hospital Clínic de Barcelona, Esplugues de Llobregat, Barcelona, 08950
Paediatrics department
Universitat de Barcelona
Barcelona, 08007
Jordán-García I:
Paediatric Intensive Care Unit
Hospital Sant Joan de Déu, University of Barcelona
Esplugues de Llobregat, Barcelona, 08950
Spain
Institut de Recerca Sant Joan de Déu, University of Barcelona, Esplugues de Llobregat, Barcelona, 08950
Paediatrics department
Universitat de Barcelona
Barcelona, 08007
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