CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation.
Por:
Cereijo R, Gavaldà-Navarro A, Cairo M, Quesada T, Villarroya-Terrade J, Morón S, Sánchez-Infantes D, Peyrou M, Iglesias R, Mampel T, Turatsinze JV, Eizirik DL, Giralt M and Villarroya-Gombau F
Publicada:
6 nov 2018
Ahead of Print:
16 ago 2018
Resumen:
The beneficial effects of brown adipose tissue (BAT) are attributed to its capacity to oxidize metabolites and produce heat, but recent data suggest that secretory properties of BAT may also be involved. Here, we identify the chemokine CXCL14 (C-X-C motif chemokine ligand-14) as a novel regulatory factor secreted by BAT in response to thermogenic activation. We found that the CXCL14 released by brown adipocytes recruited alternatively activated (M2) macrophages. Cxcl14-null mice exposed to cold showed impaired BAT activity and low recruitment of macrophages, mainly of the M2 phenotype, into BAT. CXCL14 promoted the browning of white fat and ameliorated glucose/insulin homeostasis in high-fat-diet-induced obese mice. Impairment of type 2 cytokine signaling, as seen in Stat6-null mice, blunts the action of CXCL14, promoting adipose tissue browning. We propose that active BAT is a source of CXCL14, which concertedly promotes adaptive thermogenesis via M2 macrophage recruitment, BAT activation, and the browning of white fat.
Filiaciones:
Cereijo R:
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
Gavaldà-Navarro A:
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
Cairo M:
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
Quesada T:
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
Villarroya-Terrade J:
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain
Institut de Recerca Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain
Morón S:
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain
Sánchez-Infantes D:
Department of Endocrinology and Nutrition, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Catalonia, Spain
Peyrou M:
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
Iglesias R:
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
Mampel T:
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
Turatsinze JV:
Laboratory of Experimental Medicine, ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium
Eizirik DL:
Laboratory of Experimental Medicine, ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium
Giralt M:
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
Institut de Recerca Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain
Villarroya-Gombau F:
Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of the University of Barcelona, Barcelona, Catalonia, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Barcelona, Catalonia, Spain
Institut de Recerca Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain
Open Access
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