Physical multimorbidity and depression: A mediation analysis of influential factors among 34,129 adults aged =50 years from low- and middle-income countries.
Por:
Smith L, Shin JI, Butler L, Barnett Y, Hans Oh, Jacob L., Kostev K, Veronese N, Soysal P, Tully M, López Sánchez GF and Koyanagi A
Publicada:
1 may 2022
Ahead of Print:
21 mar 2022
Resumen:
BACKGROUND: There is a scarcity of literature on the association between physical multimorbidity (i.e., =2 chronic physical conditions) and depression among older adults, especially from low- and middle-income countries (LMICs). In addition, the mediators in this association are largely unknown. Therefore, we aimed to examine this association among adults aged =50 years from six LMICs (China, Ghana, India, Mexico, Russia, and South Africa), and to identify potential mediators. METHODS: Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health were analyzed. Depression was defined as past-12 months DSM-IV depression or receiving depression treatment in the last 12 months. Information on 11 chronic physical conditions were obtained. Multivariable logistic regression and mediation analyses were conducted. RESULTS: Data on 34,129 individuals aged =50 years were analyzed [mean (SD) age 62.4 (16.0) years; maximum 114 years; 52.1% females]. Compared to no chronic conditions, 2, 3, 4, and =5 chronic conditions were associated with 2.55 (95% CI = 1.90-3.42), 3.12 (95% CI = 2.25-4.34), 5.68 (95% CI = 4.02-8.03), and 8.39 (95% CI = 5.87-12.00) times higher odds for depression. Pain/discomfort (% mediated 39.0%), sleep/energy (33.2%), mobility (27.5%), cognition (13.8%), perceived stress (7.3%), disability (6.7%), loneliness (5.5%), and food insecurity (1.5%) were found to be significant mediators in the association between physical multimorbidity and depression. CONCLUSIONS: Older adults with physical multimorbidity are at increased odds of depression in LMICs. Future studies should assess whether addressing the identified potential mediators in people with physical multimorbidity can lead to reduction in depression in this population.
Filiaciones:
Smith L:
Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
Butler L:
Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK
Barnett Y:
Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK
Hans Oh:
Suzanne Dworak Peck School of Social Work, University of Southern California, Los Angeles, California, USA
Jacob L.:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Barcelona, Spain
Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Versailles, France
Kostev K:
University Hospital of Marburg, Marburg, Germany
Veronese N:
Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science King Saud University, Riyadh, Saudi Arabia
Department of Internal Medicine, Geriatrics Section, University of Palermo, Palermo, Italy
Soysal P:
Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
Tully M:
School of Health Sciences, Institute of Mental Health Sciences, Ulster University, Newtownabbey, Ireland
López Sánchez GF:
Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Barcelona, Spain
ICREA, Barcelona, Spain
Green Published, Green Accepted, gold
|