The burden of mental disorders, substance use disorders and self-harm among young people in Europe, 1990-2019: Findings from the Global Burden of Disease Study 2019.


Por: Castelpietra G, Knudsen AKS, Agardh EE, Armocida B, Beghi M, Iburg KM, Logroscino G, Ma R, Starace F, Steel N, Addolorato G, Andrei CL, Andrei T, Ayuso-Mateos JL, Banach M, Bärnighausen TW, Barone-Adesi F, Bhagavathula AS, Carvalho F, Carvalho M, Chandan JS, Chattu VK, Couto RAS, Cruz-Martins N, Dargan PI, Deuba K, da Silva DD, Fagbamigbe AF, Fernandes E, Ferrara P, Fischer F, Gaal PA, Gialluisi A, Haagsma JA, Haro JM, Hasan MT, Hasan SS, Hostiuc S, Iacoviello L, Iavicoli I, Jamshidi E, Jonas JB, Joo T, Jozwiak JJ, Katikireddi SV, Kauppila JH, Khan MAB, Kisa A, Kisa S, Kivimäki M, Koly KN, Koyanagi A, Kumar M, Lallukka T, Langguth B, Ledda C, Lee PH, Lega I, Linehan C, Loureiro JA, Madureira-Carvalho ÁM, Martinez-Raga J, Mathur MR, McGrath JJ, Mechili EA, Mentis AA, Mestrovic T, Miazgowski B, Mirica A, Mirijello A, Moazen B, Mohammed S, Mulita F, Nagel G, Negoi I, Negoi RI, Nwatah VE, Padron-Monedero A, Panda-Jonas S, Pardhan S, Pasovic M, Patel J, Petcu IR, Pinheiro M, Pollok RCG, Postma MJ, Rawaf DL, Rawaf S, Romero-Rodríguez E, Ronfani L, Sagoe D, Sanmarchi F, Schaub MP, Sharew NT, Shiri R, Shokraneh F, Sigfusdottir ID, Silva JP, Silva R, Socea B, Szócska M, Tabarés-Seisdedos R, Torrado M, Tovani-Palone MR, Vasankari TJ, Veroux M, Viner RM, Werdecker A, Winkler AS, Hay SI, Ferrari AJ, Naghavi M, Allebeck P and Monasta L

Publicada: 1 may 2022 Ahead of Print: 1 abr 2022
Resumen:
BACKGROUND: Mental health is a public health issue for European young people, with great heterogeneity in resource allocation. Representative population-based studies are needed. The Global Burden of Disease (GBD) Study 2019 provides internationally comparable information on trends in the health status of populations and changes in the leading causes of disease burden over time. METHODS: Prevalence, incidence, Years Lived with Disability (YLDs) and Years of Life Lost (YLLs) from mental disorders (MDs), substance use disorders (SUDs) and self-harm were estimated for young people aged 10-24 years in 31 European countries. Rates per 100,000 population, percentage changes in 1990-2019, 95% Uncertainty Intervals (UIs), and correlations with Sociodemographic Index (SDI), were estimated. FINDINGS: In 2019, rates per 100,000 population were 16,983 (95% UI 12,823 - 21,630) for MDs, 3,891 (3,020 - 4,905) for SUDs, and 89·1 (63·8 - 123·1) for self-harm. In terms of disability, anxiety contributed to 647·3 (432-912·3) YLDs, while in terms of premature death, self-harm contributed to 319·6 (248·9-412·8) YLLs, per 100,000 population. Over the 30 years studied, YLDs increased in eating disorders (14·9%;9·4-20·1) and drug use disorders (16·9%;8·9-26·3), and decreased in idiopathic developmental intellectual disability (-29·1%;23·8-38·5). YLLs decreased in self-harm (-27·9%;38·3-18·7). Variations were found by sex, age-group and country. The burden of SUDs and self-harm was higher in countries with lower SDI, MDs were associated with SUDs. INTERPRETATION: Mental health conditions represent an important burden among young people living in Europe. National policies should strengthen mental health, with a specific focus on young people. FUNDING: The Bill and Melinda Gates Foundation.

Filiaciones:
Castelpietra G:
 Outpatient and Inpatient Care Service, Central Health Directorate, Region Friuli Venezia Giulia, Italy

Knudsen AKS:
 Centre for Disease Burden, Norwegian Institute of Public Health, Bergen, Norway

Agardh EE:
 Department of Global Public Health, Karolinska Institute, Stockholm, Sweden

Armocida B:
 Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, National Institute of Health, Rome, Italy

Beghi M:
 Department of Mental Health, AUSL Romagna, Ravenna, Italy

Iburg KM:
 Department of Public Health, Aarhus University, Aarhus, Denmark

Logroscino G:
 Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy

 Department of Clinical Research in Neurology, Fondazione Cardinale Giovanni Panico Hospital, Tricase, Italy

Ma R:
 Institute for Health Metrics and Evaluation, Department of Health Metrics Sciences, University of Washington, Seattle, WA, USA

Starace F:
 Department of Mental Health & Drug Abuse, AUSL Modena, Modena, Italy

Steel N:
 Department of Primary Care and Public Health, University of East Anglia, Norwich, UK

 Public Health England, London, UK

Addolorato G:
 Department of Internal Medicine, Catholic University of Rome, Rome, Italy

Andrei CL:
 Cardiology Department Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Andrei T:
 Department of Statistics and Econometrics Bucharest Carol Davila University of Economic Studies, Bucharest, Romania

Ayuso-Mateos JL:
 CIBERSAM, Institute of Health Carlos III, Madrid, Spain

 Department of Psychiatry, Universidad Autónoma de Madrid (Autonomous University of Madrid), Madrid, Spain

Banach M:
 Department of Hypertension, Medical University of Lodz, Lodz, Poland

 Polish Mothers' Memorial Hospital Research Institute, Lodz, Poland

Bärnighausen TW:
 Heidelberg Institute of Global Health (HIGH), Heidelberg University, Heidelberg, Germany

 T.H. Chan School of Public Health, Harvard University, Boston, MA, USA

Barone-Adesi F:
 Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy

Bhagavathula AS:
 Department of Social and Clinical Pharmacy, Charles University, Hradec Kralova, Czech Republic

 Institute of Public Health, United Arab Emirates University, Al Ain, United Arab Emirates

Carvalho F:
 Research Unit on Applied Molecular Biosciences (UCIBIO), University of Porto, Porto, Portugal

Carvalho M:
 Research Unit on Applied Molecular Biosciences (UCIBIO), University of Porto, Porto, Portugal

 Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal

Chandan JS:
 Institute of Applied Health Research, University of Birmingham, Birmingham, UK

Chattu VK:
 Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad and Tobago

 Independent Consultant, Athens, Greece

Couto RAS:
 Department of Chemical Sciences, University of Porto, Porto, Portugal

Cruz-Martins N:
 Department of Medicine (Prof N Cruz-Martins PhD), University of Porto, Porto, Portugal

 Department of Health Sciences Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Famalicão, Portugal

Dargan PI:
 Faculty of Life Sciences and Medicine, King's College London, London, UK

 Department of Clinical Toxicology, Guy's and St. Thomas' NHS Foundation Trust, London, UK

Deuba K:
 National Centre for AIDS and STD Control, Save the Children, Kathmandu, Nepal

 Department of Global Public Health, Karolinska Institute, Stockholm, Sweden

da Silva DD:
 Laboratory of Toxicology, University of Porto, Porto, Portugal

Fagbamigbe AF:
 Epidemiology and Medical Statistics, University of Ibadan, Ibadan, Nigeria

 Population and Behavioural Sciences, University of St Andrews, St Andrews, UK

Fernandes E:
 Associated Laboratory for Green Chemistry (LAQV), University of Porto, Porto, Portugal

Ferrara P:
 Research Center on Public Health, University of Milan Bicocca, Monza, Italy

Fischer F:
 Institute of Public Health, Charité Universitätsmedizin Berlin (Charité Medical University Berlin), Berlin, Germany

Gaal PA:
 Health Services Management Training Centre, Semmelweis University, Budapest, Hungary

 Department of Applied Social Sciences, Sapientia Hungarian University of Transylvania, Târgu-Mures, Romania

Gialluisi A:
 Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy

Haagsma JA:
 Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands

Haro JM:
 Research Unit, University of Barcelona, Barcelona, Spain

 Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain

Hasan MT:
 Department of Pharmacy, University of Huddersfield, Huddersfield, UK

 School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, NSW, Australia

Hasan SS:
 Department of Primary Care and Mental Health, University of Liverpool, Liverpool, UK

Hostiuc S:
 Department of Legal Medicine and Bioethics, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

 Clinical Legal Medicine Department, National Institute of Legal Medicine Mina Minovici, Bucharest, Romania

Iacoviello L:
 Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy

 Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese, Italy

Iavicoli I:
 Department of Public Health, University of Naples Federico II, Naples, Italy

Jamshidi E:
 Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehram, Iran

 Division of Pulmonary Medicine, University of Lausanne (UNIL), Lausanne, Switzerland

Jonas JB:
 Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland

 Department of Ophthalmology, Heidelberg University, Mannheim, Germany

Joo T:
 Health Services Management Training Centre, Semmelweis University, Budapest, Hungary

Jozwiak JJ:
 Department of Family Medicine and Public Health, University of Opole, Opole, Poland

Katikireddi SV:
 MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK

Kauppila JH:
 Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

 Surgery Research Unit, University of Oulu, Oulu, Finland

Khan MAB:
 Family Medicine Department, United Arab Emirates University, Al Ain, United Arab Emirates

 Primary Care Department, NHS North West London, London, UK

Kisa A:
 School of Health Sciences, Kristiania University College, Oslo, Norway

 Department of Global Community Health and Behavioral Sciences, Tulane University, New Orleans, LA, USA

Kisa S:
 Department of Nursing and Health Promotion, Oslo Metropolitan University, Oslo, Norway

Kivimäki M:
 Department of Epidemiology and Public Health University College London, London, UK

 Department of Public Health, University of Helsinki, Helsinki, Finland

Koly KN:
 Health System and Population Studies Divisions, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

 Center for Global Mental Health, London School of Hygiene & Tropical Medicine, London, UK

Koyanagi A:
 Biomedical Research Networking Center for Mental Health Network (CIBERSAM), San Juan de Dios Sanitary Park, Sant Boi de Llobregat, Spain

 Catalan Institution for research and Advanced Studies (ICREA), Barcelona, Spain

Kumar M:
 Division of Psychology and Language Sciences, University College London, London, UK

 Department of Psychiatry, University of Nairobi, Nairobi, Kenya

Lallukka T:
 Department of Public Health, University of Helsinki, Helsinki, Finland

Langguth B:
 Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany

Ledda C:
 Clinical and Experimental Medicine, University of Catania, Catania, Italy

Lee PH:
 Department of Health Sciences, University of Leicester, Leicester, UK

Lega I:
 National Center for Disease Prevention and Health Promotion, Istituto Superiore di Sanità - Italian National Insitute of Health, Rome, Italy

Linehan C:
 UCD Centre for Disability Studies, University College Dublin, Dublin, Ireland

Loureiro JA:
 Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE) University of Porto, Porto, Portugal

 School of Health, Polytechnic Institute of Porto, Portugal

Madureira-Carvalho ÁM:
 Associated Laboratory for Green Chemistry (LAQV), University of Porto, Porto, Portugal

 Institute for Research and Advanced Training in Health Sciences and Technologies, Instituto Universitário de Ciências da Saúde (University Institute of Health Sciences), Gandra, Portugal

Martinez-Raga J:
 Psychiatry Department, Hospital Universitario Doctor Peset, Valencia, Spain

 Department of Medicine, University of Valencia, Valencia, Spain

Mathur MR:
 Health Policy Research Public Health Foundation of India, Gurugram, India

 Institute of Population Health Sciences, University of Liverpool, Liverpool, UK

McGrath JJ:
 Queensland Brain Institute, School of Public Health, The University of Queensland, Brisbane, QLD, Australia

 National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark

Mechili EA:
 Department of Healthcare, University of Vlora, Vlora city, Albania

 Clinic of Social and Family Medicine, University of Crete, Heraklion, Greece

Mentis AA:
 University Research Institute, National and Kapodistrian University of Athens, Athens, Greece

Mestrovic T:
 Clinical Microbiology and Parasitology Unit, Dr. Zora Profozic Polyclinic, Zagreb, Croatia

 University Centre Varazdin, University North, Varazdin, Croatia

Miazgowski B:
 Center for Innovation in Medical Education, Pomeranian Medical University, Szczecin, Poland

Mirica A:
 Department of Statistics and Econometrics Bucharest University of Economic Studies, Bucharest, Romania

Mirijello A:
 Department of Medical Sciences IRCCS Casa Sollievo della Sofferenza General Hospital, San Giovanni Rotondo, Italy

Moazen B:
 Heidelberg Institute of Global Health (HIGH), Heidelberg University, Heidelberg, Germany

 Institute of Addiction Research (ISFF), Frankfurt University of Applied Sciences, Frankfurt, Germany

Mohammed S:
 Health Systems and Policy Research Unit, Ahmadu Bello University, Zaria, Nigeria

 Department of Health Care Management, Technical University of Berlin, Berlin, Germany

Mulita F:
 Department of Surgery, General University Hospital of Patras, Patras, Greece

 Medical School, University of Thessaly, Larissa, Greece

Nagel G:
 Institute of Epidemiology and Medical Biometry Ulm University, Ulm, Germany

Negoi I:
 Department of General Surgery Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

 Department of General Surgery, Emergency Hospital of Bucharest, Bucharest, Romania

Negoi RI:
 Department of Anatomy and Embryology Romania, Bucharest, Romania

 Cardio-Aid, Bucharest, Romania

Nwatah VE:
 Department of Pediatrics, National Hospital, Abuja, Nigeria

 Department of International Public Health, University of Liverpool, Liverpool, UK

Padron-Monedero A:
 National School of Public Health Institute of Health Carlos III, Madrid, Spain

Panda-Jonas S:
 Privatpraxis, Heidelberg, Germany

Pardhan S:
 Vision and Eye Research Institute, Anglia Ruskin University, Cambridge, UK

Pasovic M:
 Institute for Health Metrics and Evaluation, Department of Health Metrics Sciences, University of Washington, Seattle, WA, USA

Patel J:
 Global Health Governance Programme, University of Edinburgh, Edinburgh, UK

 School of Dentistry, University of Leeds, Leeds, UK

Petcu IR:
 Department of Statistics and Econometrics Bucharest University of Economic Studies, Bucharest, Romania

Pinheiro M:
 Department of Chemistry, University of Porto, Porto, Portugal

Pollok RCG:
 Institute of Infection and Immunity, St George's University of London, London, UK

Postma MJ:
 University Medical Center Groningen, School of Economics and Business University of Groningen, Groningen, Netherlands

Rawaf DL:
 WHO Collaborating Centre for Public Health Education and Training Imperial College London, London, UK

Rawaf S:
 Department of Primary Care and Public Health, Imperial College London, London, UK

 University College London Hospitals, London, UK

 Academic Public Health England, London, UK

Romero-Rodríguez E:
 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain

Ronfani L:
 Clinical Epidemiology and Public Health Research Unit, Burlo Garofolo Institute for Maternal and Child Health, Trieste, Italy

Sagoe D:
 Department of Psychosocial Science University of Bergen, Bergen, Norway

Sanmarchi F:
 Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy

Schaub MP:
 Swiss Research Institute for Public Health and Addiction University of Zürich, Zurich, Switzerland

Sharew NT:
 Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE) University of Groningen, Groningen, Netherlands

 Department of Nursing, Debre Berhan University, Debre Berhan, Ethiopia

Shiri R:
 Finnish Institute of Occupational Health, Helsinki, Finland

Shokraneh F:
 London Institute for Healthcare Engineering, King's College London, London, UK

 Division of Psychiatry and Applied Psychology, University of Nottingham, Nottingham, UK

Sigfusdottir ID:
 Department of Psychology, Reykjavik University, Reykjavik, Iceland

 Department of Health and Behavior Studies, Columbia University, New York, NY, USA

Silva JP:
 Research Unit on Applied Molecular Biosciences (UCIBIO), University of Porto, Porto, Portugal

Silva R:
 Department of Biological Sciences, University of Porto, Porto, Portugal

Socea B:
 Surgery, "Sf. Pantelimon" Emergency Clinical Hospital Bucharest, Bucharest, Romania

Szócska M:
 Faculty of Health and Public Administration, Semmelweis University, Budapest, Hungary

Tabarés-Seisdedos R:
 Department of Medicine, University of Valencia, Valencia, Spain

 Carlos III Health Institute, Biomedical Research Networking Center for Mental Health Network (CiberSAM), Madrid, Spain

Torrado M:
 Psychiatry and Medical Psychology Department, University of Lisbon, Lisbon, Portugal

 Child and Adolescent Mental Health Services (CAMHS), Hospital Garcia de Orta, Almada, Portugal

Tovani-Palone MR:
 Department of Pathology and Legal Medicine, University of São Paulo, Ribeirão Preto, Brazil

 Modestum LTD, London, UK

Vasankari TJ:
 UKK Institute, Tampere, Finland

 Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

Veroux M:
 Department of Medical and Surgical Sciences and Advanced Technologies, University of Catania, Catania, Italy

Viner RM:
 UCL Great Ormond Street Institute of Child Health, University College London, London, UK

Werdecker A:
 Demographic Change and Aging Research Area, Federal Institute for Population Research, Wiesbaden, Germany

Winkler AS:
 Institute of Health and Society, University of Oslo, Oslo, Norway

 Department of Neurology, Technical University of Munich, Munich, Germany

Hay SI:
 Institute for Health Metrics and Evaluation, Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle, WA, USA

Ferrari AJ:
 Institute for Health Metrics and Evaluation, Department of Health Metrics Sciences, University of Washington, Seattle, WA, USA

 School of Public Health (A J Ferrari PhD), The University of Queensland, Brisbane, QLD, Australia

Naghavi M:
 Institute for Health Metrics and Evaluation, Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle, WA, USA

Allebeck P:
 Department of Global Public Health, Karolinska Institute, Stockholm, Sweden

Monasta L:
 Clinical Epidemiology and Public Health Research Unit, Burlo Garofolo Institute for Maternal and Child Health, Trieste, Italy
ISSN: 26667762
Editorial
ELSEVIER, RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS, Reino Unido
Tipo de documento: Article
Volumen: 16 Número:
Páginas: 100341-100341
WOS Id: 000797600600006
ID de PubMed: 35392452
imagen Green Published, Green Accepted, gold

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