COVID-19 vaccination in patients receiving allergen immunotherapy (AIT) or biologicals-EAACI recommendations
Por:
Jutel, M, Torres, MJ, Palomares, O, Akdis, CA, Eiwegger, T, Untersmayr, E, Barber, D, Zemelka-Wiacek, M, Kosowska, A, Palmer, E, Vieths, S, Mahler, V, Canonica, WG, Nadeau, K, Shamji, MH, Agache, I, Akdis, M, Khaitov, M, Alvarez-Perea, A, Alvaro-Lozano M, Atanaskovic-Markovic, M, Backer, V, Barbaud, A, Bavbek, S, de Blay, F, Bonini, M, Bonini, S, van Boven, JFM, Brockow, K, Cazzola, M, Chatzipetrou, A, Chivato, T, Cianferoni, A, Corren, J, Cristoph-Caubet, J, Dunn-Galvin, A, Ebisawa, M, Firinu, D, Gawlik, R, Gelincik, A, del Giacco, S, Mortz, CG, Hoffmann, HJ, Hoffmann-Sommergruber, K, Klimek, L, Knol, E, Lauerma, A, de Llano, LP, Matucci, A, Meyer, R, Moreira, A, Morita, H, Patil, SU, Pfaar, O, Popescu, FD, del Pozo, V, Price, OJ, van Ree, R, Fernandez-Rivas, M, Rogala, B, Romano, A, Santos, A, Sediva, A, Skypala, I, Smolinska, S, Sokolowska, M, Sturm, G, Vultaggio, A, Walusiak-Skorupa, J and Worm, M
Publicada:
1 ago 2022
Ahead of Print:
1 mar 2022
Resumen:
Immune modulation is a key therapeutic approach for allergic diseases, asthma and autoimmunity. It can be achieved in an antigen-specific manner via allergen immunotherapy (AIT) or in an endotype-driven approach using biologicals that target the major pathways of the type 2 (T2) immune response: immunoglobulin (Ig)E, interleukin (IL)-5 and IL-4/IL-13 or non-type 2 response: anti-cytokine antibodies and B-cell depletion via anti-CD20. Coronavirus disease 2019 (COVID-19) vaccination provides an excellent opportunity to tackle the global pandemics and is currently being applied in an accelerated rhythm worldwide. The vaccine exerts its effects through immune modulation, induces and amplifies the response against the severe acute respiratory syndrome coronavirus (SARS-CoV-2). Thus, as there may be a discernible interference between these treatment modalities, recommendations on how they should be applied in sequence are expected. The European Academy of Allergy and Clinical Immunology (EAACI) assembled an expert panel under its Research and Outreach Committee (ROC). This expert panel evaluated the evidence and have formulated recommendations on the administration of COVID-19 vaccine in patients with allergic diseases and asthma receiving AIT or biologicals. The panel also formulated recommendations for COVID-19 vaccine in association with biologicals targeting the type 1 or type 3 immune response. In formulating recommendations, the panel evaluated the mechanisms of COVID-19 infection, of COVID-19 vaccine, of AIT and of biologicals and considered the data published for other anti-infectious vaccines administered concurrently with AIT or biologicals.
Filiaciones:
Jutel, M:
Wroclaw Med Univ, Dept Clin Immunol, Wroclaw, Poland
ALL MED Med Res Inst, Wroclaw, Poland
Torres, MJ:
Reg Univ Hosp Malaga, Allergy Unit, IBIMA UMA ARADyAL BIONAND, Malaga, Spain
Palomares, O:
Univ Complutense Madrid, Sch Chem, Dept Biochem & Mol Biol, Madrid, Spain
Akdis, CA:
Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Zurich, Switzerland
Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland
Eiwegger, T:
Hosp Sick Children, Dept 13 Pediat, Div Immunol & Allergy, Food Allergy & Anaphylaxis Program, Toronto, ON, Canada
Hosp Sick Children, Res Inst, Translat Med Program, Toronto, ON, Canada
Univ Toronto, Fac Med, Dept Immunol, Toronto, ON, Canada
Untersmayr, E:
Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Inst Pathophysiol & Allergy Res, Vienna, Austria
Barber, D:
CEU Univ, Univ San Pablo CEU, Fac Med, Inst Med Mol Aplicada IMMA,Dept Ciencias Med Basi, Madrid, Spain
Zemelka-Wiacek, M:
Wroclaw Med Univ, Dept Clin Immunol, Wroclaw, Poland
Kosowska, A:
Wroclaw Med Univ, Dept Clin Immunol, Wroclaw, Poland
ALL MED Med Res Inst, Wroclaw, Poland
Palmer, E:
Imperial Coll London, Natl Heart & Lung Inst, Allergy & Clin Immunol,MRC & Asthma UK Ctr Allerg, Inflammat Repair & Dev,Immunomodulat & Tolerance, London, England
Vieths, S:
Paul Ehrlich Inst, Fed Inst Vaccines & Biomed, Langen, Germany
Mahler, V:
Paul Ehrlich Inst, Langen, Germany
Canonica, WG:
Humanitas Univ, Dept Biomed Sci, Milan, Italy
IRCCS Humanitas Res Hosp, Personalized Med Asthma Allergy Ctr, Milan, Italy
Nadeau, K:
Dept Med, Div Pulm Allergy & Crit Care Med, Stanford, CA USA
Shamji, MH:
Imperial Coll London, Natl Heart & Lung Inst, Allergy & Clin Immunol,MRC & Asthma UK Ctr Allerg, Inflammat Repair & Dev,Immunomodulat & Tolerance, London, England
Agache, I:
Transylvania Univ, Brasov, Romania
Akdis, M:
Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Zurich, Switzerland
Khaitov, M:
Natl Res Ctr, Inst Immunol, Lab Mol Immunol, Fed Medicobiol Agcy, Moscow, Russia
Royal Brompton & Harefield Hosp NHS Fdn Trust, London, England
Alvarez-Perea, A:
Pirogov Russian Natl Res Med Univ, Moscow, Russia
Hosp Gen Univ Gregorio Maranon, Allergy Serv, Madrid, Spain
Alvaro-Lozano M:
Gregorio Maranon Hlth Res Inst IiSGM, Madrid, Spain
Hosp St Joan de Deu, Pediat Allergy & Clin Immunol Dept, Barcelona, Spain
Inst Recerca St Joan de Deu, Barcelona, Spain
Atanaskovic-Markovic, M:
Univ Barcelona, Barcelona, Spain
Univ Belgrade, Fac Med, Belgrade, Serbia
Backer, V:
Univ Childrens Hosp Belgrade, Belgrade, Serbia
Barbaud, A:
Copenhagen Univ Hosp, Rigshosp, Dept ENT, Copenhagen, Denmark
Bavbek, S:
Sorbonne Univ, Inst Pierre Louis Epidemiol & Sante Publ, Dept Dermatol & Allergol, Hop Tenon,AP HP,INSERM, Paris, France
de Blay, F:
Ankara Univ, Fac Med, Div Allergy & Immunol, Ankara, Turkey
Bonini, M:
Strasbourg Univ Hosp, Head & Chest Dis Dept, Strasbourg, France
Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy
Bonini, S:
Imperial Coll London, Natl Heart & Lung Inst NHLI, London, England
van Boven, JFM:
Italian Natl Res Council IFT CNR, Inst Translat Pharmacol, Rome, Italy
Brockow, K:
Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD GRIAC, Dept Clin Pharm & Pharmacol, Groningen, Netherlands
Cazzola, M:
Tech Univ Munich, Dept Dermatol & Allergy Biederstein, Munich, Germany
Chatzipetrou, A:
Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy
Chivato, T:
Univ Athens, Attikon Univ Hosp, Med Sch, Dept Dermatol & Venereol,Allergy Unit D Kalogerom, Athens, Greece
Cianferoni, A:
Univ CEU San Pablo, Sch Med, Madrid, Spain
Corren, J:
Univ Penn, Childrens Hosp Philadelphia, Allergy & Immunol Div, Perelman Sch Med, Philadelphia, PA 19104 USA
Cristoph-Caubet, J:
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
Dunn-Galvin, A:
Univ Hosp Geneva, Dept Woman Children Teenagers, Pediat Allergy Unit, Geneva, Switzerland
Sechenov Univ, Fac Paediat, Moscow, Russia
Ebisawa, M:
Univ Coll Cork, Sch Appl Psychol, Cork, Ireland
Firinu, D:
Natl Hosp Org Sagamihara, Clin Res Ctr Allergy & Rheumatol, Sagamihara, Kanagawa, Japan
Gawlik, R:
Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy
Gelincik, A:
Med Univ Silesia, Dept Internal Med Allergy & Clin Immunol, Katowice, Poland
del Giacco, S:
Natl Hosp Org Sagamihara, Clin Res Ctr Allergy & Rheumatol, Sagamihara, Kanagawa, Japan
Mortz, CG:
Istanbul Univ, Istanbul Fac Med, Dept Internal Med, Div Immunol & Allerg Dis, Istanbul, Turkey
Hoffmann, HJ:
Univ Southern Denmark, Odense Univ Hosp, Odense Res Ctr Anaphylaxis ORCA, Dept Dermatol & Allergy Ctr, Odense, Denmark
Hoffmann-Sommergruber, K:
Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Inst Pathophysiol & Allergy Res, Vienna, Austria
Klimek, L:
Aarhus Univ Hosp, Dept Clin Med, Dept Resp Dis & Allergy, Aarhus, Denmark
Knol, E:
Ctr Rhinol & Allergol, Wiesbaden, Germany
Lauerma, A:
Univ Med Ctr Utrecht, Dept Immunol, Utrecht, Netherlands
Univ Med Ctr Utrecht, Dept Dermatol Allergol, Utrecht, Netherlands
de Llano, LP:
Univ Helsinki, Helsinki Univ Hosp, Dept Dermatol & Allergol, Inflammat Ctr, Helsinki, Finland
Matucci, A:
Lucus Augusti Univ Hosp, EOXI Lugo Monforte Cervo, Pneumol Serv, Biodiscovery Res Grp,Hlth Res Inst Santiago de Co, Lugo, Spain
Meyer, R:
Univ Hosp Careggi, Immunoallergol Unit, Florence, Italy
Moreira, A:
Imperial Coll, Dept Paediat, London, England
Ctr Hosp Univ Sao Joao, Immunoallergol Dept, Porto, Portugal
Univ Porto, Fac Med, Dept Pathol, Basic & Clin Immunol, Porto, Portugal
Morita, H:
Univ Porto, Inst Saude Publ, Inst Publ Hlth EPIUnit, Epidemiol Res Unit, Porto, Portugal
Patil, SU:
Natl Res Inst Child Hlth & Dev, Dept Allergy & Clin Immunol, Tokyo, Japan
Massachusetts Gen Hosp, Dept Med, Allergy & Immunol, Boston, MA 02114 USA
Massachusetts Gen Hosp, Dept Pediat, Allergy & Immunol, Boston, MA 02114 USA
Pfaar, O:
Harvard Med Sch, Boston, MA 02115 USA
Popescu, FD:
Philipps Univ Marburg, Univ Hosp Marburg, Sect Rhinol & Allergy, Dept Otorhinolaryngol Head & Neck Surg, Marburg, Germany
del Pozo, V:
Carol Davila Univ Med & Pharm, Nicolae Malaxa Clin Hosp, Dept Allergol, Bucharest, Romania
Univ Autonoma Madrid, IIS FJD, UAM, Immunol Dept,Inst Invest Sanitaria,Fdn Jimenez Di, Madrid, Spain
Price, OJ:
CIBER Enfermedades Resp CIBERES, Madrid, Spain
Univ Leeds, Fac Biol Sci, Sch Biomed Sci, Leeds, W Yorkshire, England
van Ree, R:
Univ Leeds, Leeds Inst Med Res St Jamess, Leeds, W Yorkshire, England
Fernandez-Rivas, M:
Amsterdam Univ Med Ctr, Locat AMC Dept Expt Immunol, Amsterdam, Netherlands
Amsterdam Univ Med Ctr, Locat AMC Dept Otorhinolaryngol, Amsterdam, Netherlands
Rogala, B:
Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy
Romano, A:
Univ Complutense, Hosp Clin San Carlos, Fac Med, Allergy Dept,IdISSC,ARADyAL, Madrid, Spain
Santos, A:
Oasi Res Inst IRCCS, Troina, Italy
Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Women & Childrens Hlth,Paediat Allergy, London, England
Guys & St Thomas Hosp, Childrens Allergy Serv, London, England
Kings Coll London, Sch Immunol & Microbial Sci, Peter Gorer Dept Immunobiol, London, England
Sediva, A:
Asthma UK Ctr Allerg Mech Asthma, London, England
Skypala, I:
2nd Fac Med, Dept Immunol, Prague, Czech Republic
Motol Univ Hosp, Prague, Czech Republic
Smolinska, S:
Wroclaw Med Univ, Dept Clin Immunol, Wroclaw, Poland
Sokolowska, M:
Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Zurich, Switzerland
Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland
Sturm, G:
Med Univ Graz, Dept Dermatol & Venerol, Graz, Austria
Outpatient Allergy Clin, Vienna, Austria
Vultaggio, A:
Lucus Augusti Univ Hosp, EOXI Lugo Monforte Cervo, Pneumol Serv, Biodiscovery Res Grp,Hlth Res Inst Santiago de Co, Lugo, Spain
Walusiak-Skorupa, J:
Nofer Inst Occupat Med, Dept Occupat Dis & Environm Hlth, Lodz, Poland
Worm, M:
Univ Med Berlin, Dept Dermatol Venereol & Allergol, Allergol & Immunol, Berlin, Germany
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