Molecular and Brain Volume Changes Following Aerobic Exercise, Cognitive and Combined Training in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial.
Por:
Castells Sánchez Alba, Roig-Coll F, Dacosta-Aguayo R, Lamonja-Vicente N, Torán-Monserrat P, Pera G, García-Molina A, Tormos JM, Montero-Alía P, Heras-Tébar A, Soriano-Raya JJ, Cáceres C, Domènech S, Via-Garcia M, Erickson KI and Mataró-Serrat M
Publicada:
20 abr 2022
Ahead of Print:
20 abr 2022
Resumen:
Behavioral interventions have shown promising neuroprotective effects, but the cascade of molecular, brain and behavioral changes involved in these benefits remains poorly understood. Projecte Moviment is a 12-week (5 days per week-45 min per day) multi-domain, single-blind, proof-of-concept randomized controlled trial examining the cognitive effect and underlying mechanisms of an aerobic exercise (AE), computerized cognitive training (CCT) and a combined (COMB) groups compared to a waitlist control group. Adherence was > 80% for 82/109 participants recruited (62% female; age = 58.38 ± 5.47). In this study we report intervention-related changes in plasma biomarkers (BDNF, TNF-a, HGF, ICAM-1, SDF1-a) and structural-MRI (brain volume) and how they related to changes in physical activity and individual variables (age and sex) and their potential role as mediators in the cognitive changes. Our results show that although there were no significant changes in molecular biomarker concentrations in any intervention group, changes in ICAM-1 and SDF1-a were negatively associated with changes in physical activity outcomes in AE and COMB groups. Brain volume changes were found in the CCT showing a significant increase in precuneus volume. Sex moderated the brain volume change in the AE and COMB groups, suggesting that men may benefit more than women. Changes in molecular biomarkers and brain volumes did not significantly mediate the cognitive-related benefits found previously for any group. This study shows crucial initial molecular and brain volume changes related to lifestyle interventions at early stages and highlights the value of examining activity parameters, individual difference characteristics and using a multi-level analysis approach to address these questions.
Filiaciones:
Castells Sánchez Alba:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Roig-Coll F:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Dacosta-Aguayo R:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Institut d'Investigació en Ciències de La Salut Germans Trias I Pujol (IGTP), Badalona, Spain
Lamonja-Vicente N:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Torán-Monserrat P:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Department of Medicine, Universitat de Girona, Girona, Spain
Pera G:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
García-Molina A:
Institut d'Investigació en Ciències de La Salut Germans Trias I Pujol (IGTP), Badalona, Spain
Institut Guttmann, Institut Universitari de Neurorehabilitació, Universitat Autònoma de Barcelona, Badalona, Spain
Tormos JM:
Institut d'Investigació en Ciències de La Salut Germans Trias I Pujol (IGTP), Badalona, Spain
Institut Guttmann, Institut Universitari de Neurorehabilitació, Universitat Autònoma de Barcelona, Badalona, Spain
Montero-Alía P:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Heras-Tébar A:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Soriano-Raya JJ:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Cáceres C:
Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
Domènech S:
Institut de Diagnòstic per la Imatge, Hospital Germans Trias i Pujol, Badalona, Spain
Via-Garcia M:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Erickson KI:
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States
Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, WA, Australia
Mataró-Serrat M:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Open Access
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