Regularized Functional Connectivity in Schizophrenia
Por:
RAYMOND SALVADOR CIVIL, Fuentes-Claramonte P, García-León MÁ, Ramiro N, Soler-Vidal J, Torres ML, Salgado-Pineda P, Munuera-del Cerro JL, Voineskos A and Pomarol-Clotet E
Publicada:
11 may 2022
Ahead of Print:
11 may 2022
Resumen:
Regularization may be used as an alternative to dimensionality reduction when the number of variables in a model is much larger than the number of available observations. In a recent study from our group regularized regression was employed to quantify brain functional connectivity in a sample of healthy controls using a brain parcellation and resting state fMRI images. Here regularization is applied to evaluate resting state connectivity abnormalities at the voxel level in a sample of patients with schizophrenia. Specifically, ridge regression is implemented with different degrees of regularization. Results are compared to those delivered by the weighted global brain connectivity method (GBC), which is based on averaged bivariate correlations and from the non-redundant connectivity method (NRC), a dimensionality reduction approach that applies supervised principal component regressions. Ridge regression is able to detect a larger set of abnormally connected regions than both GBC and NRC methods, including schizophrenia related connectivity reductions in fronto-medial, somatosensory and occipital structures. Due to its multivariate nature, the proposed method is much more sensitive to group abnormalities than the GBC, but it also outperforms the NRC, which is multivariate too. Voxel based regularized regression is a simple and sensitive alternative for quantifying brain functional connectivity.
Filiaciones:
RAYMOND SALVADOR CIVIL:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain
Fuentes-Claramonte P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain
García-León MÁ:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain
Ramiro N:
Department of Psychiatry, Hospital Sant Rafael, Barcelona, Spain
Soler-Vidal J:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain
Benito Menni Centre Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain
Torres ML:
Hospital Mare de Déu de la Mercé, Unitat Polivalent, Barcelona, Spain
Salgado-Pineda P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain
Munuera-del Cerro JL:
Department of Diagnostic Imaging, Hospital Sant Joan de Deu, Barcelona, Spain
Voineskos A:
Campbell Family Mental Health Research Institute, Toronto, ON, Canada
Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Pomarol-Clotet E:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain
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