Concentrations of nitrogen compounds are related to severe rhinovirus infection in infants. A time-series analysis from the reference area of a pediatric university hospital in Barcelona
Por:
Armero-Campos G, Penela-Sánchez D, Belmonte J, Gómez-Barroso D, Larrauri A, Henares-Bonilla D, Violeta Vallejo Matavera, Jordán-García I, Munoz-Almagro C, Brotons-de los Reyes P and Launes-Montana C
Publicada:
1 sep 2022
Ahead of Print:
1 jun 2022
Resumen:
Background There is scarce information focused on the effect of weather conditions and air pollution on specific acute viral respiratory infections, such as rhinovirus (RV), with a wide clinical spectrum of severity. Objective The aim of this study was to analyze the association between episodes of severe respiratory tract infection by RV and air pollutant concentrations (NOx and SO2) in the reference area of a pediatric university hospital. Methods An analysis of temporal series of daily values of NOx and SO2, weather variables, circulating pollen and mold spores, and daily number of admissions in the pediatric intensive care unit (PICU) with severe respiratory RV infection (RVi) in children between 6 months and 18 years was performed. Lagged variables for 0-5 days were considered. The study spanned from 2010 to 2018. Patients with comorbidities were excluded. Results One hundred and fifty patients were admitted to the PICU. Median age was 19 months old (interquartile range [IQR]: 11-47). No relationship between RV-PICU admissions and temperature, relative humidity, cumulative rainfall, or wind speed was found. Several logistic regression models with one pollutant and two pollutants were constructed but the best model was that which included average daily NOx concentrations. Average daily NOx concentrations were related with the presence of PICU admissions 3 days later (odds ratio per IQR-unit increase: 1.64, 95% confidence interval: 1.20-2.25)). Conclusions This study has shown a positive correlation between NOx concentrations at Lag 3 and children's PICU admissions with severe RV respiratory infection. Air pollutant data should be taken into consideration when we try to understand the severity of RVis.
Filiaciones:
Armero-Campos G:
Pediatrics Department, Hospital Sant Joan de Deu, Barcelona, Spain
:
Pediatrics Intensive Care Unit, Hospital Sant Joan de Deu, Barcelona, Spain
Belmonte J:
Botanic Unit of Animal Biology, Vegetal Biology and Ecology Department. Science and Ambiental Technology Institute, Universitat Autònoma de Barcelona, Barcelona, Spain
Gómez-Barroso D:
Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Larrauri A:
Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Henares-Bonilla D:
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Grupo de investigación en enfermedades infecciosas pediátricas. Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain
Violeta Vallejo Matavera:
Pediatrics Department, Hospital Sant Joan de Deu, Barcelona, Spain
Jordán-García I:
Pediatrics Intensive Care Unit, Hospital Sant Joan de Deu, Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Grupo de investigación en enfermedades infecciosas pediátricas. Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain
Universitat de Barcelona, Barcelona, Spain
Munoz-Almagro C:
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Grupo de investigación en enfermedades infecciosas pediátricas. Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain
Molecular Microbiology Department, Hospital Sant Joan de Déu, Barcelona, Spain
Universitat Internacional de Catalunya, Barcelona, Spain
Brotons-de los Reyes P:
Grupo de investigación en enfermedades infecciosas pediátricas. Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain
Universitat Internacional de Catalunya, Barcelona, Spain
Launes-Montana C:
Pediatrics Department, Hospital Sant Joan de Deu, Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Grupo de investigación en enfermedades infecciosas pediátricas. Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain
Universitat de Barcelona, Barcelona, Spain
Green Submitted, Bronze
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