Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
Por:
Solé-Martí X, Vilella T, Labay C, Tampieri F, Ginebra MP and Canal-Barnils C
Publicada:
12 jul 2022
Ahead of Print:
1 jun 2022
Resumen:
Hydrogels have been recently proposed as suitable materials to generate reactive oxygen and nitrogen species (RONS) upon gas-plasma treatment, and postulated as promising alternatives to conventional cancer therapies. Acting as delivery vehicles that allow a controlled release of RONS to the diseased site, plasma-treated hydrogels can overcome some of the limitations presented by plasma-treated liquids in in vivo therapies. In this work, we optimized the composition of a methylcellulose (MC) hydrogel to confer it with the ability to form a gel at physiological temperatures while remaining in the liquid phase at room temperature to allow gas-plasma treatment with suitable formation of plasma-generated RONS. MC hydrogels demonstrated the capacity for generation, prolonged storage and release of RONS. This release induced cytotoxic effects on the osteosarcoma cancer cell line MG-63, reducing its cell viability in a dose-response manner. These promising results postulate plasma-treated thermosensitive hydrogels as good candidates to provide local anticancer therapies.
Filiaciones:
Solé-Martí X:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, and Research Centre for Biomedical Engineering (CREB), Universitat Politècnica de Catalunya (UPC), c/Eduard Maristany 14, 08019 Barcelona, Spain.
Barcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain
Vilella T:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, and Research Centre for Biomedical Engineering (CREB), Universitat Politècnica de Catalunya (UPC), c/Eduard Maristany 14, 08019 Barcelona, Spain.
Barcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, Spain
Labay C:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, and Research Centre for Biomedical Engineering (CREB), Universitat Politècnica de Catalunya (UPC), c/Eduard Maristany 14, 08019 Barcelona, Spain.
Barcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain
Tampieri F:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, and Research Centre for Biomedical Engineering (CREB), Universitat Politècnica de Catalunya (UPC), c/Eduard Maristany 14, 08019 Barcelona, Spain.
Barcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain
Ginebra MP:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, and Research Centre for Biomedical Engineering (CREB), Universitat Politècnica de Catalunya (UPC), c/Eduard Maristany 14, 08019 Barcelona, Spain.
Barcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, Spain
Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), c/Baldiri i Reixach 10-12, 08028 Barcelona, Spain
Canal-Barnils C:
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, and Research Centre for Biomedical Engineering (CREB), Universitat Politècnica de Catalunya (UPC), c/Eduard Maristany 14, 08019 Barcelona, Spain.
Barcelona Research Center in Multiscale Science and Engineering, UPC, 08019 Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain
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