The role of YKL-40 in the pathogenesis of autoimmune diseases: a comprehensive review.
Por:
Tizaoui K, Yang JW, Lee KH, Kim JH, Kim M, Yoon S, Jung Y, Park JB, An K, Choi H, Song D, Jung H, Ahn S, Yuh T, Choi HM, Ahn JH, Kim Y, Jee S, Lee H, Jin S, Kang JG, Koo B, Lee JY, Min KM, Yoo W, Rhyu HJ, Yoon Y, Lee MH, Kim SE, Hwang J, Koyanagi A, Jacob L., Park S, Shin JI and Smith L
Publicada:
21 may 2022
Ahead of Print:
21 may 2022
Resumen:
YKL-40, a chitinase-3-like protein 1 (CHI3L1) or human cartilage glycoprotein 39 (HC gp-39), is expressed and secreted by various cell-types including macrophages, chondrocytes, fibroblast-like synovial cells and vascular smooth muscle cells. Its biological function is not well elucidated, but it is speculated to have some connection with inflammatory reactions and autoimmune diseases. Although having important biological roles in autoimmunity, there were only attempts to elucidate relationships of YKL-40 with a single or couple of diseases in the literature. Therefore, in order to analyze the relationship between YKL-40 and the overall diseases, we reviewed 51 articles that discussed the association of YKL-40 with rheumatoid arthritis, psoriasis, systemic lupus erythematosus, Behçet disease and inflammatory bowel disease. Several studies showed that YKL-40 could be assumed as a marker for disease diagnosis, prognosis, disease activity and severity. It is also shown to be involved in response to disease treatment. However, other studies showed controversial results particularly in the case of Behçet disease activity. Therefore, further studies are needed to elucidate the exact role of YKL-40 in autoimmunity and to investigate its potential in therapeutics.
Filiaciones:
Tizaoui K:
Laboratory Microorganismes and Active Biomolecules, Sciences Faculty of Tunis, University Tunis El Manar, Tunis, Tunisia
Yang JW:
Department of Nephrology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
Lee KH:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea
Kim JH:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea
Kim M:
Yonsei University College of Medicine, Seoul, Republic of Korea
Yoon S:
Yonsei University College of Medicine, Seoul, Republic of Korea
Jung Y:
Yonsei University College of Medicine, Seoul, Republic of Korea
Park JB:
Yonsei University College of Medicine, Seoul, Republic of Korea
An K:
Yonsei University College of Medicine, Seoul, Republic of Korea
Choi H:
Yonsei University College of Medicine, Seoul, Republic of Korea
Song D:
Yonsei University College of Medicine, Seoul, Republic of Korea
Jung H:
Yonsei University College of Medicine, Seoul, Republic of Korea
Ahn S:
Yonsei University College of Medicine, Seoul, Republic of Korea
Yuh T:
Yonsei University College of Medicine, Seoul, Republic of Korea
Choi HM:
Yonsei University College of Medicine, Seoul, Republic of Korea
Ahn JH:
Yonsei University College of Medicine, Seoul, Republic of Korea
Kim Y:
Yonsei University College of Medicine, Seoul, Republic of Korea
Jee S:
Yonsei University College of Medicine, Seoul, Republic of Korea
Lee H:
Yonsei University College of Medicine, Seoul, Republic of Korea
Jin S:
Yonsei University College of Medicine, Seoul, Republic of Korea
Kang JG:
Yonsei University College of Medicine, Seoul, Republic of Korea
Koo B:
Yonsei University College of Medicine, Seoul, Republic of Korea
Lee JY:
Yonsei University College of Medicine, Seoul, Republic of Korea
Min KM:
Yonsei University College of Medicine, Seoul, Republic of Korea
Yoo W:
Yonsei University College of Medicine, Seoul, Republic of Korea
Rhyu HJ:
Yonsei University College of Medicine, Seoul, Republic of Korea
Yoon Y:
Yonsei University College of Medicine, Seoul, Republic of Korea
Lee MH:
Yonsei University College of Medicine, Seoul, Republic of Korea
Kim SE:
Yonsei University College of Medicine, Seoul, Republic of Korea
Hwang J:
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
Koyanagi A:
Parc Sanitari Sant Joan de Deu/CIBERSAM, ISCIII, Universitat de Barcelona, Fundacio Sant Joan de Deu, Sant Boi de Llobregat, Barcelona, Spain
ICREA, Pg. Lluís Companys 23, Barcelona, Spain
Jacob L.:
Parc Sanitari Sant Joan de Deu/CIBERSAM, ISCIII, Universitat de Barcelona, Fundacio Sant Joan de Deu, Sant Boi de Llobregat, Barcelona, Spain
Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France
Park S:
Yonsei University College of Medicine, Seoul, Republic of Korea
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea
Smith L:
The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK
Green Accepted, gold
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