Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect
Por:
Fuentes-Claramonte P, Ramiro N, Torres L, Argila-Plaza I, Salgado-Pineda P, Soler-Vidal J, García-León MÁ, Albacete A, Bosque C, Panicalli F, Boix E, Munuera-del Cerro JL, Tristany J, Sarró S, Bernardo M, Salvador R, McKenna PJ and Pomarol-Clotet E
Publicada:
16 jul 2022
Ahead of Print:
16 jul 2022
Resumen:
Background: The negative symptoms of schizophrenia have been proposed to reflect prefrontal cortex dysfunc-tion. However, this proposal has not been consistently supported in functional imaging studies, which have also used executive tasks that may not capture key aspects of negative symptoms such as lack of volition.Method: Twenty-four DSM-5 schizophrenic patients with high negative symptoms (HNS), 25 with absent negative symptoms (ANS) and 30 healthy controls underwent fMRI during performance of the Computerized Multiple Elements Test (CMET), a task designed to measure poor organization of goal directed behaviour or 'goal neglect'. Negative symptoms were rated using the PANSS and the Clinical Assessment Interview for Negative Symptoms (CAINS).Results: On whole brain analysis, the ANS patients showed no significant clusters of reduced activation compared to the healthy controls. In contrast, the HNS patients showed hypoactivation compared to the healthy controls in the left anterior frontal cortex, the right dorsolateral prefrontal cortex (DLPFC), the anterior insula bilaterally and the bilateral inferior parietal cortex. When compared to the ANS patients, the HNS patients showed reduced activation in the left anterior frontal cortex, the left DLPFC and the left inferior parietal cortex. After controlling for disorganization scores, differences remained in clusters in the left anterior frontal cortex and the bilateral inferior parietal cortex.Conclusions: This study provides evidence that reduced prefrontal activation, perhaps especially in the left anterior frontal cortex, is a brain functional correlate of negative symptoms in schizophrenia. The simultaneous finding of reduced inferior parietal cortex activation was unexpected, but could reflect this region's involvement in cognitive control, particularly the 'regulative' component of this.
Filiaciones:
Fuentes-Claramonte P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain
Ramiro N:
Psychiatry Department, Hospital Sant Rafael, Barcelona, Spain
Torres L:
Hospital Mare de Déu de la Mercé, Unitat Polivalent, Barcelona, Spain
Argila-Plaza I:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Salgado-Pineda P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain
Soler-Vidal J:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain
Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain
García-León MÁ:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain
Albacete A:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain
Bosque C:
Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain
Panicalli F:
Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain
Boix E:
Mental Health Department, Hospital de Mataró, Mataró, Spain
Munuera-del Cerro JL:
Diagnostic Imaging Department, Hospital Sant Joan de Déu, Barcelona, Spain
Tristany J:
Hospital Sagrat Cor, Martorell, Barcelona, Spain
Sarró S:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain
Bernardo M:
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain
Barcelona Clínic Schizophrenia Unit, Hospital Clínic of Barcelona, Institute of Neuroscience, Barcelona, Spain
Universitat de Barcelona, Barcelona, Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Salvador R:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain
McKenna PJ:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain
Pomarol-Clotet E:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain
Open Access
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