Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients: Study protocol of the MindFit project randomized controlled trial
Por:
Bermudo-Gallaguet A, Ariza M, Dacosta-Aguayo R, Agudelo D, Camins-Vila N, Boldó M, Carrera Ò, Vidal S, Ferrer-Uris B, Busquets A, Via-Garcia M, Pera G, Cáceres C, Gomis M, García-Molina A, Tormos JM, Arrabé A, Diez G, Durà Mata MJ, Torán-Monserrat P, Soriano-Raya JJ, Domènech S, Perera A, Erickson KI and Mataró-Serrat M
Publicada:
29 sep 2022
Ahead of Print:
29 sep 2022
Resumen:
Background: Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized cognitive training (CCT) may benefit stroke patients by impacting neuroplasticity and brain health. Materials and methods: One hundred and forty-one chronic stroke patients are randomly allocated to receive mindfulness-based stress reduction + CCT (n = 47), multicomponent PE program + CCT (n = 47), or CCT alone (n = 47). Interventions consist of 12-week home-based programs five days per week. Before and after the interventions, we collect data from cognitive, psychological, and physical tests, blood and stool samples, and structural and functional brain scans. Results: The effects of the interventions on cognitive and emotional outcomes will be described in intention-to-treat and per-protocol analyses. We will also explore potential mediators and moderators, such as genetic, molecular, brain, demographic, and clinical factors in our per-protocol sample. Discussion: The MindFit Project is a randomized clinical trial that aims to assess the impact of mindfulness and PE combined with CCT on chronic stroke patients' cognitive and emotional wellbeing. Furthermore, our design takes a multimodal biopsychosocial approach that will generate new knowledge at multiple levels of evidence, from molecular bases to behavioral changes.
Filiaciones:
Bermudo-Gallaguet A:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Ariza M:
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Department of Medicine, University of Barcelona, Barcelona, Spain
Dacosta-Aguayo R:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Agudelo D:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Camins-Vila N:
Institut Nacional d'Educació Física de Catalunya, University of Barcelona, Barcelona, Spain
Boldó M:
Department of Physical Medicine and Rehabilitation, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
Carrera Ò:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Vidal S:
Germans Trias i Pujol Research Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
Ferrer-Uris B:
Institut Nacional d'Educació Física de Catalunya, University of Barcelona, Barcelona, Spain
Busquets A:
Institut Nacional d'Educació Física de Catalunya, University of Barcelona, Barcelona, Spain
Via-Garcia M:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Pera G:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Germans Trias i Pujol Research Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
Cáceres C:
Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
Gomis M:
Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
García-Molina A:
Institut Guttmann, Institut Universitari de Neurorehabilitació, Universitat Autònoma de Barcelona, Badalona, Spain
Tormos JM:
Institut Guttmann, Institut Universitari de Neurorehabilitació, Universitat Autònoma de Barcelona, Badalona, Spain
Arrabé A:
Nirakara Lab, Mindfulness and Cognitive Science Extraordinary Chair, Universidad Complutense de Madrid, Madrid, Spain
Diez G:
Nirakara Lab, Mindfulness and Cognitive Science Extraordinary Chair, Universidad Complutense de Madrid, Madrid, Spain
Durà Mata MJ:
Department of Physical Medicine and Rehabilitation, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
Torán-Monserrat P:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Germans Trias i Pujol Research Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
Soriano-Raya JJ:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Domènech S:
Institut de Diagnòstic per la Imatge, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
Perera A:
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
B2SLab, Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya, Barcelona, Spain
Erickson KI:
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States
PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain
Mataró-Serrat M:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
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