The serotonin receptor 3E variant is a risk factor for female IBS-D

Por: Fritz N, Berens S, Dong Y, Martínez C, Schmitteckert S, Houghton LA, Goebel-Stengel M, Wahl V, Kabisch M, Götze D, D'Amato M, Zheng T, Röth R, Mönnikes H, Tesarz J, Engel F, Gauss A, Raithel M, Andresen V, Keller J, Frieling T, Pehl C, Stein-Thöringer C, Clarke G, Kennedy PJ, Cryan JF, Dinan TG, Quigley EMM, Spiller R, Beltrán C, Madrid AM, Torres V, Mayer EA, Sayuk G, Gazouli M, Karamanolis G, Bustamante M, Estivil X, Rabionet-Janssen R, Hoffmann P, Nöthen MM, Heilmann-Heimbach S, Schmidt B, Franke A, Lieb W, Herzog W, Boeckxstaens G, Wouters MM, Simrén M, Rappold GA, Vicario M, Santos J, Schaefert R, Lorenzo-Bermejo J and Niesler B

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Publicada: 1 nov 2022 Ahead of Print: 1 sep 2022

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Filiaciones:
Fritz N:
 Institute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany

Berens S:
 Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany

Dong Y:
 Institute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany

Martínez C:
 Institute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany

 Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain

 Lleida Institute for Biomedical Research Dr, Pifarré Foundation (IRBLleida), Lleida, Spain

Schmitteckert S:
 Institute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany.

Houghton LA:
 University of Leeds, St. James's University Hospital, Leeds, UK

 Mayo Clinic, Jacksonville, FL, USA

Goebel-Stengel M:
 Department of Psychosomatic Medicine, University Hospital Tübingen, Tübingen, Germany

 Department of Internal Medicine and Gastroenterology, HELIOS Clinic Rottweil, Rottweil, Germany

Wahl V:
 Institute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany

Kabisch M:
 Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Germany

Götze D:
 Institute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany

D'Amato M:
 Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

 Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Bilbao, Derio, Spain

 Ikerbasque, Basque Foundation for Science, Bilbao, Spain

Zheng T:
 Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

Röth R:
 Institute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany

 nCounter Core Facility, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany

Mönnikes H:
 Martin-Luther-Hospital, Berlin, Germany

Tesarz J:
 Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany

Engel F:
 Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany

Gauss A:
 Department of Gastroenterology, Infectious Diseases and Intoxications, Heidelberg University, Heidelberg, Germany

Raithel M:
 University of Erlangen, Erlangen, Germany

Andresen V:
 Israelitisches Krankenhaus, Hamburg, Germany

Keller J:
 Israelitisches Krankenhaus, Hamburg, Germany

Frieling T:
 Helios Klinik Krefeld, Krefeld, Germany

Pehl C:
 Krankenhaus Vilsbiburg, Vilsbiburg, Germany

Stein-Thöringer C:
 German Cancer Research Center, Heidelberg, Germany

Clarke G:
 Department of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland

 APC Microbiome Ireland, University College Cork, Cork, Ireland

Kennedy PJ:
 Department of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland

 APC Microbiome Ireland, University College Cork, Cork, Ireland

Cryan JF:
 Department of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland

 APC Microbiome Ireland, University College Cork, Cork, Ireland

 Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland

Dinan TG:
 Department of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland

 APC Microbiome Ireland, University College Cork, Cork, Ireland

Quigley EMM:
 APC Microbiome Ireland, University College Cork, Cork, Ireland

 Lynda K. and David M. Underwood Center for Digestive Disorders, Houston Methodist Hospital, Weill Cornell Medical College, Houston, TX, USA

Spiller R:
 Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK

Beltrán C:
 Gastroenterology Unit, Medicine Department, Hospital Clínico Universidad de Chile, Universidad de Chile, Santiago de Chile, Chile

Madrid AM:
 Gastroenterology Unit, Medicine Department, Hospital Clínico Universidad de Chile, Universidad de Chile, Santiago de Chile, Chile

Torres V:
 Gastroenterology Unit, Medicine Department, Hospital Clínico Universidad de Chile, Universidad de Chile, Santiago de Chile, Chile

Mayer EA:
 Oppenheimer Center for Neurobiology of Stress, University of California, Los Angeles, CA, USA

Sayuk G:
 Washington University School of Medicine, St. Louis, MO, USA

Gazouli M:
 Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

Karamanolis G:
 Academic Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece

Bustamante M:
 CRG, Centre for Genomic Regulation, Barcelona, Spain

 ISGlobal, Barcelona, Spain

Estivil X:
 Department of Genetics, Microbiology and Statistics, Faculty of Biology, IBUB, Universitat de Barcelona, CIBERER, IRSJD, Barcelona, Spain

Rabionet-Janssen R:
 Department of Genetics, Microbiology and Statistics, Faculty of Biology, IBUB, Universitat de Barcelona, CIBERER, IRSJD, Barcelona, Spain

Hoffmann P:
 Life and Brain Center, Bonn, Germany

Nöthen MM:
 Life and Brain Center, Bonn, Germany

Heilmann-Heimbach S:
 Life and Brain Center, Bonn, Germany

Schmidt B:
 Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany

Franke A:
 Institute of Clinical Molecular Biology, Kiel, Germany

Lieb W:
 Institute of Epidemiology, Kiel, Germany

Herzog W:
 Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany

Boeckxstaens G:
 TARGID, University Hospital Leuven, Louvain, Belgium

Wouters MM:
 TARGID, University Hospital Leuven, Louvain, Belgium

Simrén M:
 Institute of Medicine, University of Gothenburg, Gothenburg, Sweden

Rappold GA:
 Institute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany

 Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany

Vicario M:
 Institut de Recerca Vall d Hebron, Hospital Vall d Hebron, Passeig de la Vall d Hebron, Barcelona, Spain

 Nestlé Institute of Health Sciences, Nestlé Research, Société Des Produits Nestlé S.A, Vers-chez-les-Blanc, Lausanne, Switzerland

Santos J:
 Institut de Recerca Vall d Hebron, Hospital Vall d Hebron, Passeig de la Vall d Hebron, Barcelona, Spain

Schaefert R:
 Department of Psychosomatic Medicine, Division of Theragnostics, University Hospital Basel, Basel, Switzerland

 Faculty of Medicine, University of Basel, Basel, Switzerland

Lorenzo-Bermejo J:
 Institute of Medical Biometry and Informatics, Heidelberg University, Heidelberg, Germany

Niesler B:
 Institute of Human Genetics, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany

 nCounter Core Facility, Department of Human Molecular Genetics, Heidelberg University Hospital, Heidelberg, Germany

 Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany