Focusing on Comorbidity-A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders
Por:
Fortea L, Albajes-Eizagirre A, Yao YW, Soler E, Verdolini N, Hauson AO, Fortea A, Madero S, Solanes A, Wollman SC, Serra-Blasco M, Wise T, Lukito S, Picó-Pérez M, Carlisi C, Zhang J, Pan P, Farré-Colomés Á, Arnone D, Kempton MJ, Soriano-Mas C, Rubia K, Norman L, Fusar-Poli P, Mataix-Cols D, Valentí M, Via E, Cardoner N, Solmi M, Shin JI, Vieta E and Radua J
Publicada:
18 ene 2022
Ahead of Print:
18 ene 2022
Categoría:
Psychiatry and mental health
Resumen:
Background: In mental health, comorbidities are the norm rather than the exception. However, current meta-analytic methods for summarizing the neural correlates of mental disorders do not consider comorbidities, reducing them to a source of noise and bias rather than benefitting from their valuable information.Objectives: We describe and validate a novel neuroimaging meta-analytic approach that focuses on comorbidities. In addition, we present the protocol for a meta-analysis of all major mental disorders and their comorbidities.Methods: The novel approach consists of a modification of Seed-based d Mapping-with Permutation of Subject Images (SDM-PSI) in which the linear models have no intercept. As in previous SDM meta-analyses, the dependent variable is the brain anatomical difference between patients and controls in a voxel. However, there is no primary disorder, and the independent variables are the percentages of patients with each disorder and each pair of potentially comorbid disorders. We use simulations to validate and provide an example of this novel approach, which correctly disentangled the abnormalities associated with each disorder and comorbidity. We then describe a protocol for conducting the new meta-analysis of all major mental disorders and their comorbidities. Specifically, we will include all voxel-based morphometry (VBM) studies of mental disorders for which a meta-analysis has already been published, including at least 10 studies. We will use the novel approach to analyze all included studies in two separate single linear models, one for children/adolescents and one for adults.Discussion: The novel approach is a valid method to focus on comorbidities. The meta-analysis will yield a comprehensive atlas of the neuroanatomy of all major mental disorders and their comorbidities, which we hope might help develop potential diagnostic and therapeutic tools.
Filiaciones:
Fortea L:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Department of Medicine, University of Barcelona, Barcelona, Spain
Albajes-Eizagirre A:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Yao YW:
Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany
Einstein Center for Neurosciences Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany
Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany
Soler E:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Verdolini N:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Department of Medicine, University of Barcelona, Barcelona, Spain
Bipolar and Depressive Disorders Unit, Hospital Clinic, Barcelona, Spain
Hauson AO:
Clinical Psychology PhD Program, California School of Professional Psychology, San Diego, CA, United States
Department of Psychiatry, University of California San Diego, La Jolla, CA, United States
Fortea A:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Department of Medicine, University of Barcelona, Barcelona, Spain
Fundació Clínic per a la Recerca Biomèdica (FCRB), Barcelona, Spain
Psychiatric and Psychology Service, Hospital Clinic, Barcelona, Spain
Madero S:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Schizophrenia Unit, Hospital Clinic, Barcelona, Spain
Solanes A:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona, Barcelona, Spain
Wollman SC:
Clinical Psychology PhD Program, California School of Professional Psychology, San Diego, CA, United States
Serra-Blasco M:
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Department of Psychology, Abat Oliba CEU ("Centro de Estudios Universitarios") University, Barcelona, Spain
Programa E-Health ICOnnecta't, Institut Català d'Oncologia, Barcelona, Spain
Wise T:
Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom
Lukito S:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom
Picó-Pérez M:
Live and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal
ICVS/3B's, PT Government Associate Laboratory, Braga, Portugal
Clinical Academic Center - Braga, Braga, Portugal
Carlisi C:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom
Division of Psychology and Language Sciences, University College London, London, United Kingdom
Zhang J:
State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China
Pan P:
Department of Neurology, Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Affiliated Yancheng Hospital of Southeast University, Yancheng, China
Farré-Colomés Á:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Arnone D:
Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom
Department of Psychiatry and Behavioral Science, College of Medicine and Health Sciences, United Arab Emirates University (UAEU), Al Ain, United Arab Emirates
Kempton MJ:
Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom
Soriano-Mas C:
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Psychiatry and Mental Health Group, Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
Department of Psychobiology and Methodology of Health Sciences, Universitat Autònoma de Barcelona, Barcelona, Spain
Rubia K:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom
Norman L:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom
Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States
The Social and Behavioral Research Branch, National Human Genome Research Institute, National Institute of Health, Bethesda, MD, United States
Fusar-Poli P:
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom
Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology, London, United Kingdom
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
Outreach and Support in South London (OASIS) Service, South London and Maudsley NHS Foundation Trust, London, United Kingdom
Mataix-Cols D:
Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden
Valentí M:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Department of Medicine, University of Barcelona, Barcelona, Spain
Bipolar and Depressive Disorders Unit, Hospital Clinic, Barcelona, Spain
Psychiatric and Psychology Service, Hospital Clinic, Barcelona, Spain
Via E:
Child and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Barcelona, Spain
Cardoner N:
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona, Barcelona, Spain
Mental Health Department, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí (I3PT), Sabadell, Spain
Solmi M:
Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology, London, United Kingdom
Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada
Department of Mental Health, The Ottawa Hospital, Ottawa, ON, Canada
Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea
Vieta E:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Department of Medicine, University of Barcelona, Barcelona, Spain
Bipolar and Depressive Disorders Unit, Hospital Clinic, Barcelona, Spain
Psychiatric and Psychology Service, Hospital Clinic, Barcelona, Spain
Radua J:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom
Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
Green Submitted, Green Published, gold
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