Is there an association between depression, anxiety disorders and COVID-19 severity and mortality? A multicenter retrospective cohort study conducted in 50 hospitals in Germany.
Por:
Kostev K, Hagemann-Goebel M, Gessler N, Wohlmuth P, Feldhege J, Arnold D, Jacob L., Gunawardene M, Hölting T, Koyanagi A, Schreiber R, Smith L, Sheikhzadeh S and Wollmer MA
Publicada:
1 ene 2023
Ahead of Print:
29 nov 2022
Resumen:
BACKGROUND: The aim of this retrospective cohort study was to investigate associations between depression and anxiety disorder and the risk of COVID-19 severity and mortality in patients treated in large hospitals in Germany. METHODS: This retrospective study was based on anonymized electronic medical data from 50 public healthcare service hospitals across Germany. Multivariable logistic regression models were used to study associations between depression, anxiety and mechanical ventilation and mortality due to COVID adjusted for age, sex, time of COVID-19 diagnosis, and pre-defined co-diagnoses. RESULTS: Of 28,311 patients diagnosed with COVID-19, 1970 (6.9%) had a diagnosis of depression and 369 (1.3%) had a diagnosis of anxiety disorder prior to contracting COVID-19. While multivariable logistic regression models did not indicate any association between depression diagnosis and the risk of mechanical ventilation, depression was associated with a decreased risk of mortality (OR: 0.71; 95% CI: 0.53-0.94). There was no association between anxiety disorders and risk of mortality, but there was a strong positive association between anxiety disorders and the risk of mechanical ventilation (OR: 2.04; 95% CI: 1.35-3.10). CONCLUSION: In the present study, depression and anxiety disorder diagnoses were not associated with increased COVID-19 mortality. Anxiety disorder was strongly associated with an increased risk of mechanical ventilation. Further studies are needed to clarify how depression and anxiety disorders may influence COVID-19 severity and mortality.
Filiaciones:
Kostev K:
Epidemiology, IQVIA, Frankfurt, Germany
Hagemann-Goebel M:
Department of Behavioral Medicine, Asklepios Hospital Nord-Heidberg, Hamburg, Germany
Gessler N:
Department of Cardiology and Internal Intensive Care Medicine, Asklepios Hospital St. Georg, Hamburg, Germany
Asklepios Proresearch, Research Institute, Hamburg, Germany
Faculty of Medicine, Semmelweis University, Budapest, Hungary
Wohlmuth P:
Asklepios Proresearch, Research Institute, Hamburg, Germany
Feldhege J:
Asklepios Proresearch, Research Institute, Hamburg, Germany
Arnold D:
Department of Hematology, Oncology, Palliative Care Medicine and Rheumatology, Asklepios Hospital Altona, Hamburg, Germany
Jacob L.:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona, Spain
Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France
Gunawardene M:
Department of Cardiology and Internal Intensive Care Medicine, Asklepios Hospital St. Georg, Hamburg, Germany
Hölting T:
Department of Internal Medicine and Cardiology, Asklepios Hospital Wandsbek, Hamburg, Germany
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), ISCIII, Madrid, Spain
ICREA, Pg. Lluis Companys 23, 08010, Barcelona, Spain
Schreiber R:
Department of Anesthesiology and Intensive care medicine, Asklepios Hospital West, Hamburg, Germany
Smith L:
Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, CB1 1PT, UK
Sheikhzadeh S:
Asklepios hospitals GmbH & Co. KGaA, Hamburg, Germany
Wollmer MA:
Faculty of Medicine, Semmelweis University, Budapest, Hungary
Asklepios Klinik Nord Ochsenzoll, Asklepios Campus Hamburg, Germany
Green Published, Bronze
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