Is Dementia Associated with COVID-19 Mortality? A Multicenter Retrospective Cohort Study Conducted in 50 Hospitals in Germany.
Por:
Kostev K, Gessler N, Wohlmuth P, Arnold D, Bein B, Bohlken J, Herrlinger K, Jacob L., Koyanagi A, Nowak L, Smith L, Wesseler C, Sheikhzadeh S and Wollmer MA
Publicada:
1 ene 2023
Ahead of Print:
28 nov 2022
Resumen:
BACKGROUND: Dementia has been identified as a major predictor of mortality associated with COVID-19. OBJECTIVE: The objective of this study was to investigate the association between dementia and mortality in COVID-19 inpatients in Germany across a longer interval during the pandemic. METHODS: This retrospective study was based on anonymized data from 50 hospitals in Germany and included patients with a confirmed COVID-19 diagnosis hospitalized between March 11, 2020 and July, 20, 2022. The main outcome of the study was the association of mortality during inpatient stays with dementia diagnosis, which was studied using multivariable logistic regression adjusted for age, sex, and comorbidities as well as univariate logistic regression for matched pairs. RESULTS: Of 28,311 patients diagnosed with COVID-19, 11.3% had a diagnosis of dementia. Prior to matching, 26.5% of dementia patients and 11.5% of non-dementia patients died; the difference decreased to 26.5% of dementia versus 21.7% of non-dementia patients within the matched pairs (n = 3,317). This corresponded to an increase in the risk of death associated with dementia (OR = 1.33; 95% CI: 1.16-1.46) in the univariate regression conducted for matched pairs. CONCLUSION: Although dementia was associated with COVID-19 mortality, the association was weaker than in previously published studies. Further studies are needed to better understand whether and how pre-existing neuropsychiatric conditions such as dementia may impact the course and outcome of COVID-19.
Filiaciones:
Kostev K:
Epidemiology, IQVIA, Frankfurt, Germany
Gessler N:
Department of Cardiology and Internal Intensive Care Medicine, Asklepios Hospital St. Georg, Hamburg, Germany
Asklepios Proresearch, Research Institute, Hamburg, Germany
Faculty of Medicine, Semmelweis University, Budapest, Hungary
Wohlmuth P:
Asklepios Proresearch, Research Institute, Hamburg, Germany
Arnold D:
Department of Hematology, Oncology, Palliative Care Medicine and Rheumatology, Asklepios Hospital Altona, Hamburg, Germany
Bein B:
Department of Anesthesiology, Intensive Care, Emergency Medicine and Pain therapy, Asklepios Hospital St. Georg, Hamburg, Germany
Bohlken J:
Institute for Social Medicine, Occupational Medicine, and Public Health (ISAP) of the Medical Faculty at the University of Leipzig, Germany
Herrlinger K:
Department of Internal Medicine - Gastroenterology, Asklepios Hospital Nord-Heidberg, Hamburg, Germany
Jacob L.:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, ISCIII, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona, Spain
Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, ISCIII, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
ICREA, Pg. Lluís Companys 23, Barcelona, Spain
Nowak L:
Department of Intensive Care and Respiratory Medicine, Asklepios Hospital Munich-Gauting, Gauting, Germany
Smith L:
Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK
Wesseler C:
Department of Pneumology, Asklepios Hospital Harburg, Hamburg, Germany
Sheikhzadeh S:
Asklepios hospitals GmbH & Co. KGaA, Hamburg, Germany
Wollmer MA:
Faculty of Medicine, Semmelweis University, Budapest, Hungary
Asklepios Klinik Nord Ochsenzoll, Asklepios Campus Hamburg, Hamburg, Germany
Green Accepted, Bronze
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