Association of central obesity with unique cardiac remodelling in young adults born small for gestational age
Por:
Bernardino G, Sepúlveda-Martínez Á, Rodriguez-Lopez RM, Prat-González S, Pajuelo C, Perea RJ, Caralt MT, Crovetto F, González Ballester MA, Sitges M, Bijnens B and Crispi F
Publicada:
21 jun 2023
Ahead of Print:
1 ene 2023
Resumen:
Aims Being born small for gestational age (SGA, 10% of all births) is associated with increased risk of cardiovascular mortality in adulthood together with lower exercise tolerance, but mechanistic pathways are unclear. Central obesity is known to worsen cardiovascular outcomes, but it is uncertain how it affects the heart in adults born SGA. We aimed to assess whether central obesity makes young adults born SGA more susceptible to cardiac remodelling and dysfunction. Methods and results A perinatal cohort from a tertiary university hospital in Spain of young adults (30-40 years) randomly selected, 80 born SGA (birth weight below 10th centile) and 75 with normal birth weight (controls) was recruited. We studied the associations between SGA and central obesity (measured via the hip-to-waist ratio and used as a continuous variable) and cardiac regional structure and function, assessed by cardiac magnetic resonance using statistical shape analysis. Both SGA and waist-to-hip were highly associated to cardiac shape (F = 3.94, P < 0.001; F = 5.18, P < 0.001 respectively) with a statistically significant interaction (F = 2.29, P = 0.02). While controls tend to increase left ventricular end-diastolic volumes, mass and stroke volume with increasing waist-to-hip ratio, young adults born SGA showed a unique response with inability to increase cardiac dimensions or mass resulting in reduced stroke volume and exercise capacity. Conclusion SGA young adults show a unique cardiac adaptation to central obesity. These results support considering SGA as a risk factor that may benefit from preventive strategies to reduce cardiometabolic risk.
Filiaciones:
Bernardino G:
CREATIS, UMR 5220, U1294, University Lyon, Université Claude Bernard Lyon 1, INSA-Lyon, CNRS, Inserm, 21 Av. Jean Capelle O, Villeurbanne 69621, France
Sepúlveda-Martínez Á:
BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, Centre for Biomedical Research on Rare Diseases (CIBER-ER), Universitat de Barcelona, 1 Sabino Arana, Barcelona 08028, Spain
Fetal Medicine Unit, Department of Obstetrics and Gynecology, Hospital Clínico de la Universidad de Chile, 999 Dr. Carlos Lorca Tobar, Independencia, Región Metropolitana, Santiago de Chile 13108, Chile
Rodriguez-Lopez RM:
BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, Centre for Biomedical Research on Rare Diseases (CIBER-ER), Universitat de Barcelona, 1 Sabino Arana, Barcelona 08028, Spain
Public Health and Epidemiology Department & Clinical Specialties Department, Pontificia Universidad Javeriana Seccional Cali, Cl. 18 #118-250, Barrio Pance, Cali, Valle del Cauca 760031, Colombia
Prat-González S:
Institut Clínic Cardiovascular, Hospital Clínic, Centre for Biomedical Research on CardioVascular Diseases (CIBERCV), Universitat de Barcelona, 170 Villarroel, Barcelona 08036, Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer, 149 Roselló, Barcelona 08036, Spain
Pajuelo C:
Centre de Diagnòstic per la Imatge, Hospital Clínic, Universitat de Barcelona, 170 Villarroel, Barcelona 08036, Spain
Perea RJ:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, 149 Roselló, Barcelona 08036, Spain
Centre de Diagnòstic per la Imatge, Hospital Clínic, Universitat de Barcelona, 170 Villarroel, Barcelona 08036, Spain
Caralt MT:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, 149 Roselló, Barcelona 08036, Spain
Crovetto F:
BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, Centre for Biomedical Research on Rare Diseases (CIBER-ER), Universitat de Barcelona, 1 Sabino Arana, Barcelona 08028, Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer, 149 Roselló, Barcelona 08036, Spain
Public Health and Epidemiology Department & Clinical Specialties Department, Pontificia Universidad Javeriana Seccional Cali, Cl. 18 #118-250, Barrio Pance, Cali, Valle del Cauca 760031, Colombia
González Ballester MA:
BCN Medtech, Department of Information and Communication Technologies, Universitat Pompeu Fabra, 122 Tànger, Barcelona 08018, Spain
ICREA, 23 Passeig de Lluís Companys, Barcelona 08010, Spain
Sitges M:
Institut Clínic Cardiovascular, Hospital Clínic, Centre for Biomedical Research on CardioVascular Diseases (CIBERCV), Universitat de Barcelona, 170 Villarroel, Barcelona 08036, Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer, 149 Roselló, Barcelona 08036, Spain
Bijnens B:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, 149 Roselló, Barcelona 08036, Spain
ICREA, 23 Passeig de Lluís Companys, Barcelona 08010, Spain
Crispi F:
BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia Obstetricia i Neonatologia, Centre for Biomedical Research on Rare Diseases (CIBER-ER), Universitat de Barcelona, 1 Sabino Arana, Barcelona 08028, Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer, 149 Roselló, Barcelona 08036, Spain
Green Submitted, Bronze
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