Sex differences in symptomatology in people with schizophrenia and other psychotic disorders: protocol for a systematic review and pairwise meta-analysis of observational studies.
Por:
Ferrer-Quintero M, Verdaguer M, Marina Esteban Sanjusto, Serra C, Usall J, Ochoa S, Bighelli I and García-Mieres H
Publicada:
8 nov 2022
Ahead of Print:
8 nov 2022
Categoría:
Psychiatry and mental health
Resumen:
Sex differences in symptomatology in people with psychosis have been studied extensively in recent decades. Although studies have pointed to such differences, to date there is no review that has performed a systematic search and quantitative synthesis. In this paper, we describe the protocol for a pairwise meta-analysis comparing a range of symptom outcome measures between men and women diagnosed with a psychotic spectrum disorder at different stages of the disorder (PROSPERO registration number CRD42021264942). In August 2021 we conducted systematic searches of PsychInfo, PubMed, Web of Science, Scopus and Dialnet to identify observational studies that report data on symptoms for males and females separately. Two independent reviewers will conduct literature searches, select studies, extract data, assess the risk of bias and assess outcome quality. To assess the effect size of all outcome measures, we will conduct pairwise meta-analysis using random-effects models. The quality of studies will be evaluated using a National Heart, Lung and Blood Institute's quality assessment tool and the confidence in the results will be evaluated using the GRADE tool. Meta-regression and sensitivity analyses will be conducted to assess the robustness of the findings. No ethical problems are foreseen. Results from this study will be published in peer-reviewed journals and presented at relevant conferences.
Filiaciones:
:
Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
and Departament de Psicología Social i Quantitativa, Universitat de Barcelona, Spain
Verdaguer M:
Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Marina Esteban Sanjusto:
Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Serra C:
Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Usall J:
Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Ochoa S:
Institut de Recerca Sant Joan de Déu, Barcelona, Spain
and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
Bighelli I:
Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, Germany
García-Mieres H:
Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Health Services Research Unit, Institut Hospital del Mar de Investigacions Médiques (IMIM), Barcelona, Spain
and Department of Medicine and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain
Green Published, gold
|