EAACI Allergen Immunotherapy User's Guide
Por:
Alvaro-Lozano M, Akdis CA, Akdis M, Alviani C, Angier E, Arasi S, Arzt-Gradwohl L, Barber D, Bazire R, Cavkaytar O, Comberiati P, Dramburg S, Durham SR, Eifan AO, Forchert L, Halken S, Kirtland M, Kucuksezer UC, Layhadi JA, Matricardi PM, Muraro A, Ozdemir C, Pajno GB, Pfaar O, Potapova E, Riggioni C, Roberts G, Rodríguez Del Río P, Shamji MH, Sturm GJ and Vazquez-Ortiz M
Publicada:
1 may 2020
Resumen:
Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical efficiency relies on a well-defined immunologic mechanism promoting regulatory T cells and downplaying the immune response induced by allergens. Clinical indications have been well documented for respiratory allergy in the presence of rhinitis and/or allergic asthma, to pollens and dust mites. Patients who have had an anaphylactic reaction to hymenoptera venom are also good candidates for allergen immunotherapy. Administration of allergen is currently mostly either by subcutaneous injections or by sublingual administration. Both methods have been extensively studied and have pros and cons. Specifically in children, the choice of the method of administration according to the patient's profile is important. Although allergen immunotherapy is widely used, there is a need for improvement. More particularly, biomarkers for prediction of the success of the treatments are needed. The strength and efficiency of the immune response may also be boosted by the use of better adjuvants. Finally, novel formulations might be more efficient and might improve the patient's adherence to the treatment. This user's guide reviews current knowledge and aims to provide clinical guidance to healthcare professionals taking care of children undergoing allergen immunotherapy.
Filiaciones:
Alvaro-Lozano M:
Pediatric Allergy and Clinical Immunology Service, Hospital Sant Joan de Déu, Barcelona, Spain
Akdis CA:
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland
Akdis M:
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
Alviani C:
The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, Isle of Wight, UK
Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK
NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Angier E:
Primary Care and Population Sciences, University of Southampton, Southampton, UK
Arasi S:
Pediatric Allergology Unit, Department of Pediatric Medicine, Bambino Gesù Children's research Hospital (IRCCS), Rome, Italy
Arzt-Gradwohl L:
Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria
Barber D:
School of Medicine, Institute for Applied Molecular Medicine (IMMA), Universidad CEU San Pablo, Madrid, Spain
RETIC ARADYAL RD16/0006/0015, Instituto de Salud Carlos III, Madrid, Spain
Bazire R:
Allergy Department, Hospital Infantil Niño Jesús, ARADyAL RD16/0006/0026, Madrid, Spain
Cavkaytar O:
Department of Paediatric Allergy and Immunology, Faculty of Medicine, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey
Comberiati P:
Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
Department of Clinical and Experimental Medicine, Section of Paediatrics, University of Pisa, Pisa, Italy
Dramburg S:
Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité Medical University, Berlin, Germany
Durham SR:
Immunomodulation and Tolerance Group
Allergy and Clinical Immunology, Section of Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK
the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK
Eifan AO:
Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London and Royal Brompton Hospitals NHS Foundation Trust, London, UK
Forchert L:
Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité Medical University, Berlin, Germany
Halken S:
Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark
Kirtland M:
Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Inflammation, Repair and Development, National Heart and Lung Institute, Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, UK
Kucuksezer UC:
Aziz Sancar Institute of Experimental Medicine, Department of Immunology, Istanbul University, Istanbul, Turkey
Layhadi JA:
Immunomodulation and Tolerance Group
Allergy and Clinical Immunology, Section of Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK
the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK
Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Inflammation, Repair and Development, National Heart and Lung Institute, Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, London, UK
Matricardi PM:
Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité Medical University, Berlin, Germany
Muraro A:
The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Women and Child Health, University of Padua, Padua, Italy
Ozdemir C:
Institute of Child Health, Department of Pediatric Basic Sciences, Istanbul University, Istanbul, Turkey
Faculty of Medicine, Department of Pediatrics, Division of Pediatric Allergy and Immunology, Istanbul University, Istanbul, Turkey
Pajno GB:
Department of Pediatrics, Allergy Unit, University of Messina, Messina, Italy
Pfaar O:
Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany
Potapova E:
Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité Medical University, Berlin, Germany
:
Pediatric Allergy and Clinical Immunology Service, Institut de Reserca Sant Joan de Deú, Barcelona, Spain
Roberts G:
The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport, Isle of Wight, UK
NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Paediatric Allergy and Respiratory Medicine (MP803), Clinical & Experimental Sciences & Human Development in Health Academic Units University of Southampton Faculty of Medicine & University Hospital Southampton, Southampton, UK
Rodríguez Del Río P:
Allergy Department, Hospital Infantil Niño Jesús, ARADyAL RD16/0006/0026, Madrid, Spain
Shamji MH:
Immunomodulation and Tolerance Group
Allergy and Clinical Immunology, Section of Inflammation, Repair and Development, National Heart and Lung Institute, Imperial College London, London, UK
the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK
Sturm GJ:
Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria
Vazquez-Ortiz M:
Department of Paediatrics, Imperial College London, London, UK
Green Submitted, Bronze
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