COVID-19 severity is related to poor executive function in people with post-COVID conditions
Por:
Ariza M, Cano N, Segura B, Adan A, Bargalló N, Caldú X, Campabadal A, Jurado MA, Mataró-Serrat M, Pueyo R, Sala-Llonch R, Barrué C, Bejar J, Cortés CU, Garolera M and Junqué C
Publicada:
1 may 2023
Ahead of Print:
1 mar 2023
Resumen:
Patients with post-coronavirus disease 2019 (COVID-19) conditions typically experience cognitive problems. Some studies have linked COVID-19 severity with long-term cognitive damage, while others did not observe such associations. This discrepancy can be attributed to methodological and sample variations. We aimed to clarify the relationship between COVID-19 severity and long-term cognitive outcomes and determine whether the initial symptomatology can predict long-term cognitive problems. Cognitive evaluations were performed on 109 healthy controls and 319 post-COVID individuals categorized into three groups according to the WHO clinical progression scale: severe-critical (n = 77), moderate-hospitalized (n = 73), and outpatients (n = 169). Principal component analysis was used to identify factors associated with symptoms in the acute-phase and cognitive domains. Analyses of variance and regression linear models were used to study intergroup differences and the relationship between initial symptomatology and long-term cognitive problems. The severe-critical group performed significantly worse than the control group in general cognition (Montreal Cognitive Assessment), executive function (Digit symbol, Trail Making Test B, phonetic fluency), and social cognition (Reading the Mind in the Eyes test). Five components of symptoms emerged from the principal component analysis: the "Neurologic/Pain/Dermatologic" "Digestive/Headache", "Respiratory/Fever/Fatigue/Psychiatric" and "Smell/ Taste" components were predictors of Montreal Cognitive Assessment scores; the "Neurologic/Pain/Dermatologic" component predicted attention and working memory; the "Neurologic/Pain/ Dermatologic" and "Respiratory/Fever/Fatigue/Psychiatric" components predicted verbal memory, and the "Respirator y/ Fever/Fatigue/Psychiatric," "Neurologic/Pain/Dermatologic," and "Digestive/Headache" components predicted executive function. Patients with severe COVID-19 exhibited persistent deficits in executive function. Several initial symptoms were predictors of long-term sequelae, indicating the role of systemic inflammation and neuroinflammation in the acute-phase symptoms of COVID-19." Study Registration: www.ClinicalTrials.gov, identifier NCT05307549 and NCT05307575.
Filiaciones:
Ariza M:
Unitat de Psicologia Mèdica, Departament de Medicina, Universitat de Barcelona, Barcelona, Spain
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain
Grup de Recerca en Cervell, Cognició I Conducta, Consorci Sanitari de Terrassa (CST), Terrassa, Spain
Cano N:
Unitat de Psicologia Mèdica, Departament de Medicina, Universitat de Barcelona, Barcelona, Spain
Grup de Recerca en Cervell, Cognició I Conducta, Consorci Sanitari de Terrassa (CST), Terrassa, Spain
Departament de Ciències Bàsiques, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain
Segura B:
Unitat de Psicologia Mèdica, Departament de Medicina, Universitat de Barcelona, Barcelona, Spain
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain
Adan A:
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain
Departament de Psicologia Clínica I Psicobiologia, Universitat de Barcelona, Barcelona, Spain
Bargalló N:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Diagnostic Imaging Centre, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain
Caldú X:
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain
Departament de Psicologia Clínica I Psicobiologia, Universitat de Barcelona, Barcelona, Spain
Institut de Recerca de Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain
Campabadal A:
Unitat de Psicologia Mèdica, Departament de Medicina, Universitat de Barcelona, Barcelona, Spain
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Jurado MA:
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain
Departament de Psicologia Clínica I Psicobiologia, Universitat de Barcelona, Barcelona, Spain
Institut de Recerca de Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain
Mataró-Serrat M:
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain
Departament de Psicologia Clínica I Psicobiologia, Universitat de Barcelona, Barcelona, Spain
Institut de Recerca de Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain
Pueyo R:
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain
Departament de Psicologia Clínica I Psicobiologia, Universitat de Barcelona, Barcelona, Spain
Institut de Recerca de Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain
Sala-Llonch R:
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Departament de Biomedicina, Universitat de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain
Bejar J:
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain
Cortés CU:
Departament de Ciències de La Computació, Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain
Garolera M:
Grup de Recerca en Cervell, Cognició I Conducta, Consorci Sanitari de Terrassa (CST), Terrassa, Spain
Neuropsychology Unit, Consorci Sanitari de Terrassa (CST), Terrassa, Spain
Junqué C:
Unitat de Psicologia Mèdica, Departament de Medicina, Universitat de Barcelona, Barcelona, Spain.
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.
Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.
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