Do the negative symptoms of schizophrenia reflect reduced responsiveness to reward? Examination using a reward prediction error (RPE) task
Por:
Fuentes-Claramonte P, Garcia-Leon MA, Salgado-Pineda P, Ramiro N, Soler-Vidal J, Torres ML, Cano R, Argila-Plaza I, Panicali F, Sarri C, Jaurrieta N, Sánchez M, Boix-Quintana E, Albacete A, Maristany M, Sarró S, Raduà J, McKenna PJ, Salvador R and Pomarol-Clotet E
Publicada:
1 nov 2023
Ahead of Print:
1 mar 2023
Resumen:
Background. A leading theory of the negative symptoms of schizophrenia is that they reflect reduced responsiveness to rewarding stimuli. This proposal has been linked to abnormal (reduced) dopamine function in the disorder, because phasic release of dopamine is known to code for reward prediction error (RPE). Nevertheless, few functional imaging studies have examined if patients with negative symptoms show reduced RPE-associated activations.
Methods. Matched groups of DSM-5 schizophrenia patients with high negative symptom scores (HNS, N = 27) or absent negative symptoms (ANS, N = 27) and healthy controls (HC, N = 30) underwent fMRI scanning while they performed a probabilistic monetary reward task designed to generate a measure of RPE.
Results. In the HC, whole-brain analysis revealed that RPE was positively associated with activation in the ventral striatum, the putamen, and areas of the lateral prefrontal cortex and orbitofrontal cortex, among other regions. Group comparison revealed no activation differences between the healthy controls and the ANS patients. However, compared to the ANS patients, the HNS patients showed regions of significantly reduced activation in the left ventrolateral and dorsolateral prefrontal cortex, and in the right lingual and fusiform gyrus. HNS and ANS patients showed no activation differences in ventral striatal or midbrain regions-of-interest (ROIs), but the HNS patients showed reduced activation in a left orbitofrontal cortex ROI.
Conclusions. The findings do not suggest that a generalized reduction of RPE signalling underlies negative symptoms. Instead, they point to a more circumscribed dysfunction in the lateral frontal and possibly the orbitofrontal cortex.
Filiaciones:
Fuentes-Claramonte P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Garcia-Leon MA:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Salgado-Pineda P:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Ramiro N:
Hospital Sant Rafael, Barcelona, Spain
Soler-Vidal J:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Benito Menni CASM, Sant Boi de Llobregat, Barcelona, Spain
Universitat de Barcelona, Barcelona, Spain
Torres ML:
Hospital Mare de Déu de la Mercè, Barcelona, Spain
Cano R:
Hospital Mare de Déu de la Mercè, Barcelona, Spain
Argila-Plaza I:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Panicali F:
Benito Menni CASM, Sant Boi de Llobregat, Barcelona, Spain
Sarri C:
Benito Menni CASM, Sant Boi de Llobregat, Barcelona, Spain
Jaurrieta N:
Hospital Sagrat Cor, Martorell, Barcelona, Spain
Sánchez M:
Hospital Sagrat Cor, Martorell, Barcelona, Spain
Universitat Autònoma de Barcelona, Barcelona, Spain
Boix-Quintana E:
Mental Health Department, Hospital de Mataró, Mataró, Spain
Albacete A:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Maristany M:
Diagnostic Imaging Department, Hospital Sant Joan de Déu, Barcelona, Spain
Sarró S:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Raduà J:
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institute, Stockholm, Sweden
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
McKenna PJ:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Salvador R:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
Pomarol-Clotet E:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Instituto de Salud Carlos III, Barcelona, Spain
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