Anxiety, mood, and substance use disorders in adult men and women with and without attention-deficit/hyperactivity disorder: A substantive and methodological overview
Por:
Hartman CA, Chen Q, Solberg BS, Du Rietz E, Klungsøyr K, Cortese S, Dalsgaard S, Haavik J, Ribasés M, Mostert JC, Libutzki B, Kittel-Schneider S, Cormand B, Vos M, Larsson H, Reif A, Faraone SV and Bellato A
Publicada:
1 ago 2023
Ahead of Print:
1 may 2023
Resumen:
Knowledge on psychiatric comorbidity in adult ADHD is essential for prevention, detection, and treatment of these conditions. This review (1) focuses on large studies (n > 10,000; surveys, claims data, population registries) to identify (a) overall, (b) sex-and (c) age-specific patterns of comorbidity of anxiety disorders (ADs), major depressive disorder (MDD), bipolar disorder (BD) and substance use disorders (SUDs) in adults with ADHD relative to adults without ADHD; and (2) describes methodological challenges relating to establishing comor-bidity in ADHD in adults as well as priorities for future research. Meta-analyses (ADHD: n = 550,748; no ADHD n = 14,546,814) yielded pooled odds ratios of 5.0(CI:3.29-7.46) for ADs, 4.5(CI:2.44-8.34) for MDD, 8.7 (CI:5.47-13.89) for BD and 4.6(CI:2.72-7.80) for SUDs, indicating strong differences in adults with compared to adults without ADHD. Moderation by sex was not found: high comorbidity held for both men and women with sex-specific patterns as in the general population: higher prevalences of ADs, MDD and BD in women and a higher prevalence of SUDs in men. Insufficient data on different phases of the adult lifespan prevented con-clusions on developmental changes in comorbidity. We discuss methodological challenges, knowledge gaps, and future research priorities.
Filiaciones:
Hartman CA:
University Medical Center Groningen, Groningen, Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University of Groningen, the Netherlands
Chen Q:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Solberg BS:
Child- and adolescent psychiatric outpatient unit, Hospital Betanien, Bergen, Norway
Department of Biomedicine, University of Bergen, Norway
Du Rietz E:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Klungsøyr K:
Department of Global Public Health and Primary Care, University of Bergen, Norway
Department of Health Promotion, Norwegian Institute of Public Health, Bergen, Norway
Cortese S:
Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK
Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK
Solent NHS Trust, Southampton, UK
Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York City, New York, USA
Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, UK
Dalsgaard S:
NCRR - National Centre for Register-based Research, Aarhus University, Aarhus, Denmark
iPSYCH - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen and Aarhus, Denmark
CIRRAU - Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark
Haavik J:
Department of Biomedicine, University of Bergen, Norway
Bergen Center of Brain Plasticity, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway
Ribasés M:
Department of Psychiatry, Mental Health and Addictions, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain
Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain
Department of Genetics, Microbiology & Statistics, University of Barcelona, Barcelona, Spain
Mostert JC:
Department of Psychiatry, Donders Institute for Brain, Behaviour and Cognition, Radboud University Medical Center Nijmegen, the Netherlands
Department of Genetics, Radboud University Medical Center, Nijmegen, the Netherlands
Libutzki B:
University Medical Center Groningen, Groningen, Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University of Groningen, the Netherlands
Kittel-Schneider S:
Department of Psychiatry, Psychotherapy and Psychosomatic, University Hospital Würzburg, Würzburg, Germany
Cormand B:
Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Catalonia, Spain
Biomedical Network Research Centre on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Spain
Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Catalonia, Spain
Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Catalonia, Spain
Vos M:
University Medical Center Groningen, Groningen, Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University of Groningen, the Netherlands
Larsson H:
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
School of Medical Sciences, Örebro University, Örebro, Sweden
Reif A:
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt - Goethe University, Frankfurt am Main, Germany
Faraone SV:
Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA
Bellato A:
School of Psychology, University of Nottingham, Semenyih, Malaysia
Green Submitted, hybrid
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