Chronic Low Back Pain and Incident Transient Ischemic Attack and Stroke in General Practices in Germany
Por:
Jacob L., Smith L, Koyanagi A, Haro JM, Shin JI, Tanislav C, Schnitzler A and Kostev K
Publicada:
21 may 2023
Ahead of Print:
21 may 2023
Resumen:
The aim was to investigate the association between chronic low back pain (CLBP) and incident transient ischemic attack (TIA) and stroke in Germany. The present retrospective cohort study included adults aged >= 18 years who were diagnosed for the first time with CLBP in one of 1198 general practices in Germany in 2005-2019 (index date). Patients without CLBP were matched to those with CLBP (1:1) using a propensity score based on age, sex, the index year, the number of medical consultations per year during the follow-up, and the number of years of follow-up. In patients without CLBP, the index date was a randomly selected visit date. Both groups were followed for up to 10 years. There were 159,440 patients included in the study (mean (SD) age: 52.1 (16.5) years; 51.5% women). Within 10 years of the index date, 6.5% and 5.9% of patients with and without CLBP were diagnosed with TIA or stroke, respectively (log-rank p-value < 0.001). The Cox regression analysis corroborated these results, as there was a significant association between CLBP and incident TIA or stroke (HR = 1.28, 95% CI = 1.22-1.35). CLBP was positively and significantly associated with incident TIA and stroke in Germany. More research is warranted to better understand this relationship.
Filiaciones:
Jacob L.:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Dr. Antoni Pujadas, 42, 08830 Barcelona, Spain
Department of Physical Medicine and Rehabilitation, Lariboisière-Fernand Widal Hospital, AP-HP, University Paris Cité, 75010 Paris, France
Epidemiology of Ageing and Neurodegenerative Diseases, Université Paris Cité, Inserm U1153, 75010 Paris, France
Smith L:
Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge CB1 1PT, UK
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Dr. Antoni Pujadas, 42, 08830 Barcelona, Spain
Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluis Companys 23, 08010 Barcelona, Spain
Haro JM:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Dr. Antoni Pujadas, 42, 08830 Barcelona, Spain
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
Tanislav C:
Department of Geriatrics and Neurology, Diakonie Hospital Jung Stilling Siegen, 57074 Siegen, Germany
Schnitzler A:
Department of Physical Medicine and Rehabilitation, Lariboisière-Fernand Widal Hospital, AP-HP, University Paris Cité, 75010 Paris, France
Epidemiology of Ageing and Neurodegenerative Diseases, Université Paris Cité, Inserm U1153, 75010 Paris, France
Kostev K:
Epidemiology, IQVIA, 60549 Frankfurt, Germany
Department of Gynecology and Obstetrics, University Clinic of Marburg, 35043 Marburg, Germany
Green Published, Green Accepted, gold
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