Pain and mild cognitive impairment among adults aged 50 years and above residing in low- and middle-income countries
Por:
Smith L, López Sánchez GF, Shin JI, Soysal P, Pizzol D, Barnett Y, Kostev K, Jacob L., Veronese N, Butler L, Odell-Miller H, Bloska J, Underwood BR and Koyanagi A
Publicada:
1 jul 2023
Ahead of Print:
1 may 2023
Resumen:
BackgroundPrevious studies on the association between pain and cognitive decline or impairment have yielded mixed results, while studies from low- and middle-income countries (LMICs) or specifically on mild cognitive impairment (MCI) are scarce. Thus, we investigated the association between pain and MCI in LMICs and quantified the extent to which perceived stress, sleep/energy problems, and mobility limitations explain the pain/MCI relationship.MethodsData analysis of cross-sectional data from six LMICs from the Study on Global Ageing and Adult Health (SAGE) were performed. MCI was based on the National Institute on Aging-Alzheimer's Association criteria. "Overall in the last 30 days, how much of bodily aches or pain did you have?" was the question utilized to assess pain. Associations were examined by multivariable logistic regression analysis and meta-analysis.ResultsData on 32,715 individuals aged 50 years and over were analysed [mean (SD) age 62.1 (15.6) years; 51.7% females]. In the overall sample, compared to no pain, mild, moderate, and severe/extreme pain were dose-dependently associated with 1.36 (95% CI = 1.18-1.55), 2.15 (95% CI = 1.77-2.62), and 3.01 (95% CI = 2.36-3.85) times higher odds for MCI, respectively. Mediation analysis showed that perceived stress, sleep/energy problems, and mobility limitations explained 10.4%, 30.6%, and 51.5% of the association between severe/extreme pain and MCI.ConclusionsAmong middle-aged to older adults from six LMICs, pain was associated with MCI dose-dependently, and sleep problems and mobility limitations were identified as potential mediators. These findings raise the possibility of pain as a modifiable risk factor for developing MCI.
Filiaciones:
Smith L:
Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
López Sánchez GF:
Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain.
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea
Soysal P:
Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
Pizzol D:
Italian Agency for Development Cooperation, Khartoum, Sudan
Barnett Y:
Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Kostev K:
University Clinic of Marburg, Marburg, Germany
Jacob L.:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Dr. Antoni Pujadas, Sant Boi de Llobregat, Barcelona, Spain
Department of Physical and Rehabilitation Medicine, Lariboisière-Fernand Widal Hospital, AP-HP, University Paris Cité, Paris, France
Veronese N:
Department of Internal Medicine, Geriatrics Section, University of Palermo, Palermo, Italy
Butler L:
Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Odell-Miller H:
Cambridge Institute for Music Therapy Research, Anglia Ruskin University, Cambridge, UK
Bloska J:
Cambridge Institute for Music Therapy Research, Anglia Ruskin University, Cambridge, UK
Underwood BR:
Department of Psychiatry, University of Cambridge, Herchel Smith Building, Forvie Site, Robinson Way, Cambridge , CB2 0SZ, UK
Cambridgeshire and Peterborough NHS Foundation Trust, Windsor Unit, Fulbourn Hospital, Cambridge, CB21 5EF, UK
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Dr. Antoni Pujadas, Sant Boi de Llobregat, Barcelona, Spain
ICREA, Pg. Lluís Companys 23, 08010, Barcelona, Spain
Green Published, hybrid, Green Accepted
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