Ceramic-hydrogel composite as carrier for cold-plasma reactive-species: Safety and osteogenic capacity in vivo
Por:
Solé-Martí X, Labay C, Raymond-Llorens Y, Franch, J, Benítez R, Ginebra MP and Canal-Barnils C
Publicada:
1 ene 2023
Ahead of Print:
1 oct 2022
Resumen:
Plasma-treated hydrogels have been put forward as a potential selective osteosarcoma therapy through the release of reactive species to the diseased site. To allow their translation to the clinics, it is crucial to show that the oxidative stress delivered by such hydrogels does not adversely affect healthy tissues. This is evaluated here by investigating the in vivo performance of a robocasted calcium phosphate cement infiltrated by a plasma-treated hydrogel. The plasma-treated composite implanted in a critical size bone defect of healthy rabbits revealed its safety, allowing equivalent bone ingrowth compared to the control scaffolds and to that of direct plasma treatment of the bone defect. This opens the door for using composite biomaterials containing plasma-generated reactive species in bone therapies.
Filiaciones:
Solé-Martí X:
Univ Politecn Catalunya UPC, Biomat Biomech & Tissue Engn Grp, Dept Mat Sci & Engn, Barcelona, Spain
Univ Politecn Catalunya UPC, Res Ctr Biomed Engn CREB, Barcelona, Spain
UPC, Barcelona Res Ctr Multiscale Sci & Engn, Barcelona, Spain
Inst Recerca St Joan de Deu, Esplugas de Llobregat, Spain
Labay C:
Univ Politecn Catalunya UPC, Biomat Biomech & Tissue Engn Grp, Dept Mat Sci & Engn, Barcelona, Spain
Univ Politecn Catalunya UPC, Res Ctr Biomed Engn CREB, Barcelona, Spain
UPC, Barcelona Res Ctr Multiscale Sci & Engn, Barcelona, Spain
Inst Recerca St Joan de Deu, Esplugas de Llobregat, Spain
Raymond-Llorens Y:
Univ Politecn Catalunya UPC, Biomat Biomech & Tissue Engn Grp, Dept Mat Sci & Engn, Barcelona, Spain
Univ Politecn Catalunya UPC, Res Ctr Biomed Engn CREB, Barcelona, Spain
UPC, Barcelona Res Ctr Multiscale Sci & Engn, Barcelona, Spain
Inst Recerca St Joan de Deu, Esplugas de Llobregat, Spain
Mimetis Biomat SL, Barcelona, Spain
Franch, J:
Univ Autonoma Barcelona, Vet Sch, Small Anim Surg Dept, Bone Healing Grp, Barcelona, Spain
Benítez R:
Inst Recerca St Joan de Deu, Esplugas de Llobregat, Spain
Univ Politecn Catalunya UPC, Automat Control Dept, Barcelona, Spain
Ginebra MP:
Univ Politecn Catalunya UPC, Biomat Biomech & Tissue Engn Grp, Dept Mat Sci & Engn, Barcelona, Spain
Univ Politecn Catalunya UPC, Res Ctr Biomed Engn CREB, Barcelona, Spain
UPC, Barcelona Res Ctr Multiscale Sci & Engn, Barcelona, Spain
Barcelona Inst Sci & Technol BIST, Inst Bioengn Catalonia IBEC, Barcelona, Spain
Canal-Barnils C:
Univ Politecn Catalunya UPC, Biomat Biomech & Tissue Engn Grp, Dept Mat Sci & Engn, Barcelona, Spain
Univ Politecn Catalunya UPC, Res Ctr Biomed Engn CREB, Barcelona, Spain
UPC, Barcelona Res Ctr Multiscale Sci & Engn, Barcelona, Spain
Inst Recerca St Joan de Deu, Esplugas de Llobregat, Spain
hybrid
FULL TEXT
 |
Published Version |
https://www.wiley.com/en-us/network/publishing/research-publishing/open-access/copyright-and-licensing-with-wiley |
|
|