Dual-Action Effect of Gallium and Silver Providing Osseointegration and Antibacterial Properties to Calcium Titanate Coatings on Porous Titanium Implants.
Por:
Rodríguez-Contreras A, Torres Garrido, Diego, Piñera-Avellaneda D, Pérez-Palou L, Ortiz-Hernández M, Ginebra MP, Calero JA, Manero JM and Rupérez E
Publicada:
15 may 2023
Ahead of Print:
15 may 2023
Resumen:
Previously, functional coatings on 3D-printed titanium implants were developed to improve their biointegration by separately incorporating Ga and Ag on the biomaterial surface. Now, a thermochemical treatment modification is proposed to study the effect of their simultaneous incorporation. Different concentrations of AgNO(3) and Ga(NO(3))(3) are evaluated, and the obtained surfaces are completely characterized. Ion release, cytotoxicity, and bioactivity studies complement the characterization. The provided antibacterial effect of the surfaces is analyzed, and cell response is assessed by the study of SaOS-2 cell adhesion, proliferation, and differentiation. The Ti surface doping is confirmed by the formation of Ga-containing Ca titanates and nanoparticles of metallic Ag within the titanate coating. The surfaces generated with all combinations of AgNO(3) and Ga(NO(3))(3) concentrations show bioactivity. The bacterial assay confirms a strong bactericidal impact achieved by the effect of both Ga and Ag present on the surface, especially for Pseudomonas aeruginosa, one of the main pathogens involved in orthopedic implant failures. SaOS-2 cells adhere and proliferate on the Ga/Ag-doped Ti surfaces, and the presence of gallium favors cell differentiation. The dual effect of both metallic agents doping the titanium surface provides bioactivity while protecting the biomaterial from the most frequent pathogens in implantology.
Filiaciones:
Rodríguez-Contreras A:
Biomaterials, Biomechanics and Tissue Engineering Group (BBT), Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Escola d'Enginyeria de Barcelona Est (EEBE), Eduard Maristany 16, 08019 Barcelona, Spain
Torres Garrido, Diego:
Biomaterials, Biomechanics and Tissue Engineering Group (BBT), Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Escola d'Enginyeria de Barcelona Est (EEBE), Eduard Maristany 16, 08019 Barcelona, Spain
AMESPMTECH, Carrer de Laureà i Miró, 388, 08980 Sant Feliu de Llobregat, Spain
Piñera-Avellaneda D:
Biomaterials, Biomechanics and Tissue Engineering Group (BBT), Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Escola d'Enginyeria de Barcelona Est (EEBE), Eduard Maristany 16, 08019 Barcelona, Spain
Pérez-Palou L:
Biomaterials, Biomechanics and Tissue Engineering Group (BBT), Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Escola d'Enginyeria de Barcelona Est (EEBE), Eduard Maristany 16, 08019 Barcelona, Spain
AMESPMTECH, Carrer de Laureà i Miró, 388, 08980 Sant Feliu de Llobregat, Spain
Ortiz-Hernández M:
Biomaterials, Biomechanics and Tissue Engineering Group (BBT), Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Escola d'Enginyeria de Barcelona Est (EEBE), Eduard Maristany 16, 08019 Barcelona, Spain
Ginebra MP:
Biomaterials, Biomechanics and Tissue Engineering Group (BBT), Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Escola d'Enginyeria de Barcelona Est (EEBE), Eduard Maristany 16, 08019 Barcelona, Spain
Institute for Bioengineering of Catalonia (IBEC), Baldiri Reixac 10-12, 08028 Barcelona, Spain
Calero JA:
AMESPMTECH, Carrer de Laureà i Miró, 388, 08980 Sant Feliu de Llobregat, Spain
Manero JM:
Biomaterials, Biomechanics and Tissue Engineering Group (BBT), Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Escola d'Enginyeria de Barcelona Est (EEBE), Eduard Maristany 16, 08019 Barcelona, Spain
Rupérez E:
Biomaterials, Biomechanics and Tissue Engineering Group (BBT), Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC), Escola d'Enginyeria de Barcelona Est (EEBE), Eduard Maristany 16, 08019 Barcelona, Spain
Open Access
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