Schizophrenia polygenic risk score in psychosis proneness
Por:
Mas-Bermejo P, Papiol S, Via-Garcia M, Rovira P, Torrecilla P, Kwapil TR, Barrantes-Vidal N and Rosa A
Publicada:
1 dic 2023
Ahead of Print:
1 jun 2023
Resumen:
Schizophrenia (SZ) is a complex disorder with a highly polygenic inheritance. It can be conceived as the extreme expression of a continuum of traits that are present in the general population often broadly referred to as schizotypy. However, it is still poorly understood how these traits overlap genetically with the disorder. We investigated whether polygenic risk for SZ is associated with these disorder-related phenotypes (schizotypy, psychotic-like experiences, and subclinical psychopathology) in a sample of 253 non-clinically identified participants. Polygenic risk scores (PRSs) were constructed based on the latest SZ genome-wide association study using the PRS-CS method. Their association with self-report and interview measures of SZ-related traits was tested. No association with either schizotypy or psychotic-like experiences was found. However, we identified a significant association with the Motor Change subscale of the Comprehensive Assessment of At-Risk Mental States (CAARMS) interview. Our results indicate that the genetic overlap of SZ with schizotypy and psychotic-like experiences is less robust than previously hypothesized. The relationship between high PRS for SZ and motor abnormalities could reflect neurodevelopmental processes associated with psychosis proneness and SZ.
Filiaciones:
Mas-Bermejo P:
Secció de Zoologia i Antropologia Biològica. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals. Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain
Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
Papiol S:
Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, 80336, Munich, Germany
Max Planck Institute of Psychiatry, Munich, Germany
CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain
Via-Garcia M:
Brainlab, Cognitive Neuroscience Research Group, Department of Clinical Psychology and Psychobiology, Universitat de Barcelona, Barcelona, Spain
Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Rovira P:
Vicerectorat de Recerca, Investigadora Postdoctoral Margarita Salas, Universitat de Barcelona, Barcelona, Spain
Instituto de Neurociencias, Centro de Investigación Biomédica (CIBM), Universidad de Granada, Granada, Spain
Departamento de Psiquiatría, Facultad de Medicina, Universidad de Granada, Granada, Spain
Instituto de Investigación Biosanitaria Ibs.Granada, Granada, Spain
Torrecilla P:
Department of Clinical and Health Psychology, Universitat Autònoma de Barcelona, Barcelona, Spain
Kwapil TR:
Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, USA
Barrantes-Vidal N:
CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain
Department of Clinical and Health Psychology, Universitat Autònoma de Barcelona, Barcelona, Spain
Sant Pere Claver-Fundació Sanitària, Barcelona, Spain
Rosa A:
Secció de Zoologia i Antropologia Biològica. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals. Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.
Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain.
CIBER de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.
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