Global Incidence and Prevalence of Eosinophilic Esophagitis, 1976-2022: A Systematic Review and Meta-Analysis.
Por:
Hahn JW, Lee K, Shin JI, Cho SH, Turner S, Shin JU, Yeniova AÖ, Koyanagi A, Jacob L., Smith L, Fond G, Boyer L, Lee SW, Kwon R, Kim S, Shin YH, Rhee SY, Moon JS, Ko JS, Yon DK and Papadopoulos NG
Publicada:
1 dic 2023
Ahead of Print:
16 jun 2023
Resumen:
BACKGROUND AND AIMS: Owing to 2018 expanded diagnostic criteria for eosinophilic esophagitis (EoE) and thus a possible increase in diagnosis, previous studies on the global incidence and prevalence of EoE may need to be updated. We aimed to describe global, regional, and national trends in the incidence and prevalence of EoE from 1976 to 2022 and analyze their associations with geographic, demographic, and social factors through a systematic review. METHODS: We searched the PubMed/MEDLINE, Embase, CINAHL, Google Scholar, and Cochrane databases from their inception dates to December 20, 2022, for studies that reported the incidence or prevalence of EoE in the general population. We calculated the global incidence and prevalence of EoE using pooled estimates with 95% confidence intervals (CI) and performed subgroup analysis based on age, sex, race, geographical area, World Bank income group, and diagnostic criteria of EoE. RESULTS: Forty studies met the eligibility criteria, including over 288 million participants and 147,668 patients with EoE from 15 countries across the five continents. The global pooled incidence and prevalence of EoE were 5.31 cases per 100,000 inhabitant-years (95% CI, 3.98-6.63; number of studies, 27; sample population, 42,191,506) and 40.04 cases per 100,000 inhabitant-years (95% CI, 31.10-48.98; number of studies, 20; sample population, 30,467,177), respectively. The pooled incidence of EoE was higher in high-income countries (versus low- or middle-income countries), males, and North America (versus Europe and Asia). The global prevalence of EoE followed a similar pattern. The pooled prevalence of EoE gradually increased from 1976 to 2022 (1976-2001; 8.18 [3.67-12.69] versus 2017-2022; 74.42 [39.66-109.19] cases per 100,000 inhabitant-years). CONCLUSION: The incidence and prevalence of EoE have increased substantially and vary widely across the world. Further research is needed to evaluate the incidence and prevalence of EoE in Asia, South America, and Africa.
Filiaciones:
Hahn JW:
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
Lee K:
Digestive Disease Center, CHA Bundang Medical Center, CHA University School of Medicine, Republic of Korea
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea
Cho SH:
Division of Allergy-Immunology, University of South Florida Morsani College of Medicine, Tampa, FL, USA
Turner S:
Maternity and Child Health Division, NHS Grampian Aberdeen, UK
Shin JU:
Department of Dermatology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea
Yeniova AÖ:
Division of Gastroenterology, Department of Internal Medicine, Tokat Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey
Koyanagi A:
Research and Development Unit, Parc Sanitari Sant Joan de Deu, CIBERSAM, ISCIII, Barcelona, Spain
Catalan Institute for Research and Advanced Studies (ICREA), Pg. Lluis Companys, Barcelona, Spain
Jacob L.:
Research and Development Unit, Parc Sanitari Sant Joan de Deu, CIBERSAM, ISCIII, Barcelona, Spain
Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France
Smith L:
Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Fond G:
AP-HM, Aix-Marseille University, CEReSS, Health Service Research and Quality of Life Center, Marseille, France
FondaMental Foundation, Creteil, France
Boyer L:
AP-HM, Aix-Marseille University, CEReSS, Health Service Research and Quality of Life Center, Marseille, France
FondaMental Foundation, Creteil, France
Lee SW:
Department of Precision Medicine, Sungkyunkwan University College of Medicine, Suwon, Republic of Korea
Kwon R:
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea
Kim S:
Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea
Shin YH:
Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Republic of Korea
Rhee SY:
Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea
Department of Endocrinology and Metabolism, Kyung Hee University College of Medicine, Seoul, Republic of Korea
Moon JS:
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
Ko JS:
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
Yon DK:
Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea
Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea
Papadopoulos NG:
Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece
Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty or Biology, Medicine and Health, The University of Manchester, Manchester, UK
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