Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency


Por: Block J, Rashkova C, Castanon I, Zoghi S, Platon J, Ardy RC, Fujiwara M, Chaves B, Schoppmeyer R, van der Made CI, Jimenez Heredia R, Harms FL, Alavi S, Alsina L, Sanchez Moreno P, Ávila Polo R, Cabrera-Pérez R, Kostel Bal S, Pfajfer L, Ransmayr B, Mautner AK, Kondo R, Tinnacher A, Caldera M, Schuster M, Domínguez Conde C, Platzer R, Salzer E, Boyer T, Brunner HG, Nooitgedagt-Frons JE, Iglesias-Jimenez E, Deyà-Martinez A, Camacho-Lovillo M, Menche J, Bock C, Huppa JB, Pickl WF, Distel M, Yoder JA, Traver D, Engelhardt KR, Linden T, Kager L, Hannich JT, Hoischen A, Hambleton S, Illsinger S, Da Costa L, Kutsche K, Chavoshzadeh Z, van Buul JD, Anton-Lopez J, Calzada-Hernández J, Neth O, Viaud J, Nishikimi A, Dupré L and Boztug K
Publicada: 10 ago 2023 Ahead of Print: 1 jun 2023
Categoría: Medicine (miscellaneous)
Resumen:
BackgroundIncreasing evidence links genetic defects affecting actin-regulatory proteins to diseases with severe autoimmunity and autoinflammation, yet the underlying molecular mechanisms are poorly understood. Dedicator of cytokinesis 11 (DOCK11) activates the small Rho guanosine triphosphatase (GTPase) cell division cycle 42 (CDC42), a central regulator of actin cytoskeleton dynamics. The role of DOCK11 in human immune-cell function and disease remains unknown. MethodsWe conducted genetic, immunologic, and molecular assays in four patients from four unrelated families who presented with infections, early-onset severe immune dysregulation, normocytic anemia of variable severity associated with anisopoikilocytosis, and developmental delay. Functional assays were performed in patient-derived cells, as well as in mouse and zebrafish models. ResultsWe identified rare, X-linked germline mutations in DOCK11 in the patients, leading to a loss of protein expression in two patients and impaired CDC42 activation in all four patients. Patient-derived T cells did not form filopodia and showed abnormal migration. In addition, the patient-derived T cells, as well as the T cells from Dock11-knockout mice, showed overt activation and production of proinflammatory cytokines that were associated with an increased degree of nuclear translocation of nuclear factor of activated T cell 1 (NFATc1). Anemia and aberrant erythrocyte morphologic features were recapitulated in a newly generated dock11-knockout zebrafish model, and anemia was amenable to rescue on ectopic expression of constitutively active CDC42. ConclusionsGermline hemizygous loss-of-function mutations affecting the actin regulator DOCK11 were shown to cause a previously unknown inborn error of hematopoiesis and immunity characterized by severe immune dysregulation and systemic inflammation, recurrent infections, and anemia. (Funded by the European Research Council and others.) DOCK11, Inflammation, and Normocytic AnemiaIn this study, DOCK11 was shown to regulate T-cell shape and migration and erythroid development. Inherited loss-of-function variants in DOCK11 led to early-onset severe immune dysregulation and normocytic anemia.
Filiaciones:
Block J:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Rashkova C:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Castanon I:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Zoghi S:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Platon J:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Ardy RC:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Fujiwara M:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Chaves B:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Schoppmeyer R:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
van der Made CI:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Jimenez Heredia R:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Harms FL:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Alavi S:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Alsina L:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Sanchez Moreno P:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Ávila Polo R:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Cabrera-Pérez R:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Kostel Bal S:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Pfajfer L:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Ransmayr B:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Mautner AK:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Kondo R:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Tinnacher A:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Caldera M:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Schuster M:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Domínguez Conde C:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Platzer R:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Salzer E:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Boyer T:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Brunner HG:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Nooitgedagt-Frons JE:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Iglesias-Jimenez E:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Deyà-Martinez A:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Camacho-Lovillo M:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Menche J:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Bock C:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Huppa JB:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Pickl WF:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Distel M:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Yoder JA:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Traver D:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Engelhardt KR:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Linden T:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Kager L:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Hannich JT:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Hoischen A:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Hambleton S:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Illsinger S:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Da Costa L:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Kutsche K:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Chavoshzadeh Z:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
van Buul JD:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Anton-Lopez J:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Calzada-Hernández J:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Neth O:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Viaud J:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Nishikimi A:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Dupré L:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
Boztug K:
 the Biosafety Division, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan (M.F., R.K., A.N.)

 the National Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, and the Computational Modeling Group, Oswaldo Cruz Foundation (Fiocruz), Eusébio - both in Brazil (B.C.)

 the Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg (F.L.H., K.K.), University Children's Hospital Oldenburg, Department of Neuropediatrics, Oldenburg (T.L., S.I.), and the Center for Pediatrics and Adolescent Medicine, Department of Pediatric Kidney, Liver, and Metabolic Diseases and Neuropediatrics, Hannover Medical School, Hannover (S.I.) - all in Germany

 the Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health (S.A.), and the Allergy and Clinical Immunology Department, Mofid Children's Hospital (Z.C.), Shahid Beheshti University of Medical Sciences, Tehran, Iran

 the Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh (J.A.Y.)

 the Department of Cellular and Molecular Medicine and the Section of Cell and Developmental Biology, University of California, San Diego, La Jolla (D.T.)

 and the Primary Immunodeficiency Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom (K.R.E., S.H.)
From St. Anna Children's Cancer Research Institute (CCRI) (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., B.R., E.S., M.D., L.K., K.B.), the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (J.B., C.R., I.C., S.Z., R.C.A., R.J.H., S.K.B., L.P., B.R., A.-K.M., C.D.C., E.S., C.B., L.D., K.B.), CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (J.B., C.R., S.Z., R.C.A., R.J.H., S.K.B., B.R., A.T., M.C., M.S., C.D.C., E.S., J.M., C.B., J.T.H., K.B.),
Hématopoïèse et Immunologie (HEMATIM) Unité de Recherche 4666, Université de Picardie Jules Verne (J.P., T.B., L.D.C.), and Service d'Hématologie Biologique (Hematology Diagnostic Lab), Centre Hospitalier Universitaire d'Amiens (T.B.), Amiens, Toulouse Institute for Infectious and Inflammatory Diseases, INSERM and Paul Sabatier University (Unité Mixte de Recherche 1291), and Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5051) (B.C., L.P., L.D.), and the Institute o
the Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, the Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam University Medical Centers, University of Amsterdam, and the Leeuwenhoek Center for Advanced Microscopy, Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam (R.S., J.D.B.), the Department of Human Genetics (C.I.M., H.G.B., A.H.) and the Radboud University Medical Center for In
the Clinical Immunology and Primary Immunodeficiencies Unit, Allergy and Clinical Immunology Department (L.A., A.D.-M.), and the Pediatric Rheumatology Department (E.I., J.A., J.C.-H.), Hospital Sant Joan de Déu, the Study Group for Immune Dysfunction Diseases in Children, Institut de Recerca Sant Joan de Déu (L.A., E.I., A.D.-M., J.A., J.C.-H.), and the Department of Surgery and Surgical Specializations, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (L.A., J.A.), B
ISSN: 00284793





NEW ENGLAND JOURNAL OF MEDICINE
Editorial
MASSACHUSETTS MEDICAL SOC, WALTHAM WOODS CENTER, 860 WINTER ST, WALTHAM, MA 02451-1413, Estados Unidos America
Tipo de documento: Article
Volumen: 389 Número: 6
Páginas: 527-539
WOS Id: 001013156300001
ID de PubMed: 37342957
imagen Green Submitted

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