Children's cognitive performance and suicide risk through middle adulthood
Por:
Vidal-Ribas P, Govender, T, Yu, J, Sundaram, R, Perlis, RH and Gilman, SE
Publicada:
1 oct 2023
Ahead of Print:
1 jun 2023
Resumen:
BackgroundLongitudinal studies show that lower cognitive performance in adolescence and early adulthood is associated with higher risk of suicide death throughout adulthood. However, it is unclear whether this cognitive vulnerability originates earlier in childhood since studies conducted in children are scarce and have inconsistent results. MethodsVital status of 49,853 individuals born between 1959 and 1966 to participants in the Collaborative Perinatal Project cohort was determined by a probabilistic linkage to the National Death Index, covering all US deaths occurring from 1979 through 2016. Cox proportional hazard models were used to examine associations of general, verbal, and non-verbal intelligence at ages 4 and 7, and academic skills at age 7 with suicide death coded according to ICD-9/10 criteria, while accounting for sociodemographic and pregnancy factors previously associated with suicide in this sample. ResultsBy the end of 2016, 288 cohort members had died by suicide. Cognitive performance at 7 years on tests with verbal components was associated with suicide risk (average vs. high verbal intelligence, HR = 1.97, 95% CI 1.05-3.71; low vs. high spelling skills, HR = 2.02, 95% CI 1.16-3.51; low vs. high reading skills, HR = 2.01, 95% CI 1.27-3.17). Associations were still evident, especially for verbal intelligence and reading skills, but hazard ratios were attenuated after adjusting for prenatal and sociodemographic factors at birth (verbal intelligence, HR = 1.97, 95% CI 1.03-3.78; spelling, HR = 1.61, 95% CI 0.90-2.88; reading, HR = 1.67, 95% CI 1.02-2.72). ConclusionsChildhood neurocognitive performance is associated with vulnerability to suicide mortality through middle-adulthood, suggesting that there might be a cognitive diathesis for suicide originating in early childhood. Future studies should examine how multiple domains of childhood cognitive performance contribute to vulnerability to suicide risk, including by increasing risk for social and environmental factors that are associated not only with suicide but also with many types of psychiatric disorders.
Filiaciones:
Vidal-Ribas P:
Eunice Kennedy Shriver Natl Inst Child Hlth & Huma, Social & Behav Sci Branch, Div Populat Hlth Res, NIH, Bethesda, MD USA
Inst Recerca St Joan de Deu, Child & Adolescent Mental Hlth Res Grp, Carrer Santa Rosa 39-57,4a Planta, Barcelona 08950, Spain
Govender, T:
Eunice Kennedy Shriver Natl Inst Child Hlth & Huma, Social & Behav Sci Branch, Div Populat Hlth Res, NIH, Bethesda, MD USA
Yu, J:
Eunice Kennedy Shriver Natl Inst Child Hlth & Huma, Social & Behav Sci Branch, Div Populat Hlth Res, NIH, Bethesda, MD USA
Sundaram, R:
Eunice Kennedy Shriver Natl Inst Child Hlth & Huma, Biostat & Bioinformat Branch, Div Populat Hlth Res, NIH, Bethesda, MD USA
Perlis, RH:
Massachusetts Gen Hosp, Ctr Quantitat Hlth, Ctr Genom Med, Dept Psychiat, Boston, MA USA
Harvard Med Sch, Dept Psychiat, Boston, MA USA
Gilman, SE:
Eunice Kennedy Shriver Natl Inst Child Hlth & Huma, Social & Behav Sci Branch, Div Populat Hlth Res, NIH, Bethesda, MD USA
Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA
Green Submitted
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