Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke

Por: Jaworek, T, Xu, HC, Gaynor, BJ, Cole, JW, Rannikmae, K, Stanne, TM, Tomppo, L, Abedi, V, Amouyel, P, Armstrong, ND, Attia, J, Bell, S, Benavente, OR, Boncoraglio, GB, Butterworth, A, Carcel-Marquez, J, Chen, ZM, Chong, M, Cruchaga, C, Cushman, M, Danesh, J, Debette, S, Duggan, DJ, Durda, JP, Engstrom, G, Enzinger, C, Faul, JD, Fecteau, NS, Fernandez-Cadenas, I, Gieger, C, Giese, AK, Grewal, RP, Grittner, U, Havulinna, AS, Heitsch, L, Hochberg, MC, Holliday, E, Hu, J, Ilinca, A, Irvin, MR, Jackson, RD, Jacob, MA, Rabionet-Janssen R, Jimenez-Conde, J, Johnson, JA, Kamatani, Y, Kardia, SLR, Koido, M, Kubo, M, Lange, L, Lee, JM, Lemmens, R, Levi, CR, Li, J, Li, LM, Lin, K, Lopez, H, Luke, S, Maguire, J, McArdle, PF, McDonough, CW, Meschia, JF, Metso, T, Muller-Nurasyid, M, O'Connor, TD, O'Donnell, M, Peddareddygari, LR, Pera, J, Perry, JA, Peters, A, Putaala, J, Ray, D, Rexrode, K, Ribases, M, Rosand, J, Rothwell, PM, Rundek, T, Ryan, KA, Sacco, RL, Salomaa, V, Sanchez-Mora, C, Schmidt, R, Sharma, P, Slowik, A, Smith, JA, Smith, NL, Wassertheil-Smoller, S, Soderholm, M, Stine, OC, Strbian, D, Sudlow, CLM, Tatlisumak, T, Terao, C, Thijs, V, Torres-Aguila, NP, Tregouet, DA, Tuladhar, AM, Veldink, JH, Walters, RG, Weir, DR, Woo, D, Worrall, BB, Hong, CC, Ross, OA, Zand, R, de Leeuw, FE, Lindgren, AG, Pare, G, Anderson, CD, Markus, HS, Jern, C, Malik, R, Dichgans, M, Mitchell, BD and Kittner, SJ

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Publicada: 18 oct 2022 Ahead of Print: 17 oct 2022

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Filiaciones:
Jaworek, T:
 Univ Maryland, Sch Med, Div Endocrinol, Baltimore, MD 21201 USA

Xu, HC:
 Univ Maryland, Sch Med, Div Endocrinol, Baltimore, MD 21201 USA

Gaynor, BJ:
 Univ Maryland, Sch Med, Div Endocrinol, Baltimore, MD 21201 USA

Cole, JW:
 Univ Maryland, Dept Neurol, Diabet & Nutr, Baltimore, MD 21201 USA

 VA Maryland Hlth Care Syst, Baltimore, MD USA

Rannikmae, K:
 Univ Edinburgh, Usher Inst, Med Informat Ctr, Edinburgh, Midlothian, Scotland

Stanne, TM:
 Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Lab Med, Gothenburg, Sweden

Tomppo, L:
 Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland

Abedi, V:
 Geisinger Hlth Syst, Dept Mol & Funct Genom, Danville, PA USA

Amouyel, P:
 Univ Lille, LabEx DISTALZ, RID AGE Risk Factors & Mol Determinants Aging Rel, U1167, Lille, France

 Inserm, U1167, Lille, France

 Ctr Hosp Univ Lille, Lille, France

 Inst Pasteur, Lille, France

Armstrong, ND:
 Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA

Attia, J:
 Univ Newcastle, Sch Med & Publ Hlth, Callaghan, NSW, Australia

Bell, S:
 Univ Cambridge, Stroke Res Grp, Cambridge, England

Benavente, OR:
 Univ British Columbia, Dept Neurol, Vancouver, BC, Canada

Boncoraglio, GB:
 Fdn IRCCS Ist Neurol Carlo Besta, Dept Cerebrovasc Dis, Milan, Italy

Butterworth, A:
 Univ Cambridge, Dept Clin Neurosci, British Heart Fdn Cardiovasc Epidemiol Unit, Cambridge, England

 Univ Cambridge, Dept Publ Hlth & Primary Care, British Heart Fdn Ctr Res Excellence, Cambridge, England

 Univ Cambridge, Natl Inst Hlth Res, Blood & Transplant Res Unit Donor Hlth & Genom, Cambridge, England

 Univ Cambridge, Cambridge, England

 Hlth Data Res UK Cambridge, Cambridge, England

 Wellcome Genome Campus, Cambridge, England

Carcel-Marquez, J:
 Biomed Res Inst St Pau IIB St Pau, Stroke Pharmacogen & Genet Grp, Barcelona, Spain

Chen, ZM:
 Univ Oxford, Nuffield Dept Populat Hlth, MRC Populat Hlth Res Unit, Oxford, England

Chong, M:
 McMaster Univ, DBCVS Res Inst, Dept Pathol & Mol Med, Populat Hlth Res Inst, Hamilton, ON, Canada

 Thrombosis & Atherosclerosis Res Inst TaARI, Hamilton, ON, Canada

Cruchaga, C:
 Washington Univ, Sch Med, Dept Psychiat, St Louis, MO USA

Cushman, M:
 Univ Vermont, Larner Coll Med, Dept Med, Burlington, VT USA

Danesh, J:
 Univ Cambridge, Dept Clin Neurosci, British Heart Fdn Cardiovasc Epidemiol Unit, Cambridge, England

 Univ Cambridge, Dept Publ Hlth & Primary Care, British Heart Fdn Ctr Res Excellence, Cambridge, England

 Univ Cambridge, Natl Inst Hlth Res, Blood & Transplant Res Unit Donor Hlth & Genom, Cambridge, England

 Univ Cambridge, Cambridge, England

 Hlth Data Res UK Cambridge, Cambridge, England

 Wellcome Genome Campus, Cambridge, England

 Wellcome Sanger Inst, Dept Human Genet, Hinxton, England

Debette, S:
 Univ Bordeaux, Inserm Bordeux Populat Hlth Res Ctr, UMR 1219, Bordeaux, France

 Bordeaux Univ Hosp, Inst Neurodegenerat Dis, Dept Neurol, Bordeaux, France

Duggan, DJ:
 Affiliate City Hope, Translat Genom Res Inst, Quantitat Med & Syst Biol Div, Phoenix, AZ USA

Durda, JP:
 Univ Vermont, Larner Coll Med, Dept Med, Burlington, VT USA

 Univ Vermont, Larner Coll Med, Lab Clin Biochem Res, Burlington, VT USA

 Lab Clin Biochem Res, Malmo, Sweden

Engstrom, G:
 Dept Clin Sci, Malmo, Sweden

Enzinger, C:
 Med Univ Graz, Dept Neurol, Graz, Austria

Faul, JD:
 Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA

Fecteau, NS:
 Univ Maryland, Dept Neurol, Diabet & Nutr, Baltimore, MD 21201 USA

Fernandez-Cadenas, I:
 Biomed Res Inst St Pau IIB St Pau, Stroke Pharmacogen & Genet Grp, Barcelona, Spain

 Fundacio Docencia & Recerca MutuaTerrassa, Stroke Pharmacogen & Genet, Terrassa, Spain

Gieger, C:
 Helmholtz Zentrum Munchen German Res Ctr Environm, Unit Mol Epidemiol, Neuherberg, Germany

 Helmholtz Zentrum Munchen German Res Ctr Environm, Inst Epidemiol, Neuherberg, Germany

Giese, AK:
 Univ Klinikum Hamburg Eppendorf, Kopf & Neurozentrum, Klin & Poliklin Neurol, Hamburg, Germany

Grewal, RP:
 St Francis Med Ctr, Neurosci Inst, Trenton, NJ USA

Grittner, U:
 Charite Univ Med Ctr, Dept Biostat & Clin Epidemiol, Berlin, Germany

Havulinna, AS:
 Natl Inst Hlth & Welf, Helsinki, Finland

Heitsch, L:
 Washington Univ, Sch Med, Dept Neurol, St Louis, MO USA

 Washington Univ, Sch Med, Dept Emergency Med, St Louis, MO USA

Hochberg, MC:
 Univ Maryland, Div Rheumatol & Clin Immunol, Baltimore, MD 21201 USA

 Univ Maryland, Dept Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA

Holliday, E:
 Univ Newcastle, Sch Med & Publ Hlth, Callaghan, NSW, Australia

Hu, J:
 Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

Ilinca, A:
 Lund Univ, Dept Clin Sci, Neurol, Lund, Sweden

 Skane Univ Hosp, Dept Neurol & Rehabil Med, Lund, Sweden

Irvin, MR:
 Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA

Jackson, RD:
 Ohio State Univ, Dept Internal Med, Div Endocrinol Diabet & Metab, Columbus, OH USA

Jacob, MA:
 Radboud Univ Nijmegen Med Ctr, Donders Med Ctr Neurosci, Dept Neurol, Nijmegen, Netherlands

Rabionet-Janssen R:
 Univ Barcelona, Inst Biomed IBUB, Dept Genet Microbiol & Stat, Barcelona, Spain

 Inst Recerca St Joan de Deu, Esplugas de Llobregat, Spain

 Univ Autonoma Barcelona, Ctr Invest Biomed Red CIBERER, Barcelona, Spain

Jimenez-Conde, J:
 Univ Autonoma Barcelona, Inst Hosp Mar Invest Med, Dept Neurol, Neurovasc Res Grp, Barcelona, Spain

Johnson, JA:
 Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA

 Univ Florida, Coll Pharm, Ctr Pharmacogen, Gainesville, FL USA

 Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA

Kamatani, Y:
 Univ Tokyo, Inst Med Sci, Lab Complex Trait Genom, Tokyo, Japan

Kardia, SLR:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI USA

Kubo, M:
 Univ Tokyo, Inst Med Sci, Grad Sch Frontier Sci, Tokyo, Japan

 Univ Tokyo, Inst Med Sci, Dept Canc Biol, Tokyo, Japan

 RIKEN Ctr Integrat Med Sci, Dept Canc Biol, Yokohama, Kanagawa, Japan

 RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

Lee, JM:
 Washington Univ, Sch Med, Dept Neurol, St Louis, MO USA

Lemmens, R:
 KU Leuven Univ Leuven, VIB Ctr Brain & Dis Res, Dept Neurosci, Expt Neurol, Leuven, Belgium

 Univ Hosp Leuven, Dept Neurol, Leuven, Belgium

Levi, CR:
 Hunter Med Res Inst, John Hunter Hosp, Newcastle, NSW, Australia

Li, J:
 Geisinger Hlth Syst, Dept Mol & Funct Genom, Danville, PA USA

Li, LM:
 Univ Colorado Denver, Dept Med, Anschutz Med Campus, Aurora, CO USA

 Peking Univ, Dept Epidemiol & Biostat, Peking Univ Hlth Sci Ctr, Beijing, Peoples R China

Lopez, H:
 Univ Maryland, Dept Neurol, Diabet & Nutr, Baltimore, MD 21201 USA

Luke, S:
 Mayo Clin, Dept Neurol, Jacksonville, FL USA

Maguire, J:
 Univ Technol Sydney, Sch Nursing & Midwifery, Fac Hlth, Sydney, NSW, Australia

McArdle, PF:
 Univ Maryland, Sch Med, Div Endocrinol, Baltimore, MD 21201 USA

McDonough, CW:
 Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA

 Univ Florida, Coll Pharm, Ctr Pharmacogen, Gainesville, FL USA

Meschia, JF:
 Mayo Clin, Dept Neurol, Jacksonville, FL USA

Metso, T:
 Helsinki Univ Cent Hosp, Dept Neurol, Helsinki, Finland

Muller-Nurasyid, M:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany

O'Connor, TD:
 Univ Maryland, Inst Genome Sci, Baltimore, MD 21201 USA

O'Donnell, M:
 Natl Univ Ireland, Hlth Res Board Clin Res Facil Geata Eolais, Galway, Ireland

Peddareddygari, LR:
 St Francis Med Ctr, Neurosci Inst, Trenton, NJ USA

Perry, JA:
 Univ Maryland, Sch Med, Div Endocrinol, Baltimore, MD 21201 USA

Peters, A:
 Helmholtz Zentrum Munchen German Res Ctr Environm, Inst Epidemiol, Neuherberg, Germany

 Ludwig Maximilians Univ Munchen, Inst Med Informat Sci Biometry & Epidemiol, Munich, Germany

Putaala, J:
 Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland

 Jagiellonian Univ, Dept Neurol, Krakow, Poland

Ray, D:
 Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

Rexrode, K:
 Harvard Med Sch, Brigham & Womens Hosp, Div Womens Hlth, Boston, MA USA

Ribases, M:
 Univ Autonoma Barcelona, Vall dHebron Res Inst VHIR, Grp Psychiat Mental Hlth & Addict, Psychiat Genet Unit, Barcelona, Spain

 Inst Salud Carlos III, Biomed Network Res Ctr Mental Hlth CIBERSAM, Madrid, Spain

 Univ Barcelona, Fac Biol, Dept Genet Microbiol & Stat, Barcelona, Spain

Rosand, J:
 Massachusetts Gen Hosp, McCance Ctr Brain Hlth, Boston, MA USA

 MGH, Ctr Genom Med, Boston, MA USA

 MGH, Dept Neurol, Boston, MA USA

 Broad Inst, Program Med & Populat Genet, Cambridge, MA USA

Rothwell, PM:
 Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

Rundek, T:
 Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA

 Univ Miami, Miller Sch Med, Evelin F McKnight Brain Inst, Coral Gables, FL 33124 USA

Ryan, KA:
 Univ Maryland, Sch Med, Div Endocrinol, Baltimore, MD 21201 USA

Sacco, RL:
 Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA

 Univ Miami, Miller Sch Med, Evelin F McKnight Brain Inst, Coral Gables, FL 33124 USA

Salomaa, V:
 Natl Inst Hlth & Welf, Helsinki, Finland

Sanchez-Mora, C:
 Univ Autonoma Barcelona, Vall dHebron Res Inst VHIR, Grp Psychiat Mental Hlth & Addict, Psychiat Genet Unit, Barcelona, Spain

 Hosp Univ Vall dHebron, Dept Psychiat, Barcelona, Spain

Schmidt, R:
 Med Univ Graz, Dept Neurol, Graz, Austria

Sharma, P:
 Royal Holloway Univ London, Inst Cardiovasc Res, London, England

 Ashford & St Peters Hosp, Surrey, England

Slowik, A:
 Jagiellonian Univ, Dept Neurol, Krakow, Poland

Smith, JA:
 Dept Clin Sci, Malmo, Sweden

Smith, NL:
 Univ Washington, Grp Hlth Cooperat, Grp Hlth Res Inst, Seattle, WA USA

 Univ Washington, Dept Epidemiol, Seattle, WA USA

 VA Off Res & Dev, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA

Wassertheil-Smoller, S:
 Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USA

Soderholm, M:
 Dept Clin Sci, Malmo, Sweden

 Lund Univ, Dept Clin Sci, Neurol, Lund, Sweden

Strbian, D:
 Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland

Sudlow, CLM:
 Univ Edinburgh, Usher Inst, Med Informat Ctr, Edinburgh, Midlothian, Scotland

 Hlth Data Res UK, BHF Data Sci Ctr, London, England

Tatlisumak, T:
 Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland

 Sahlgrens Univ Hosp, Reg Vastra Gotaland, Dept Neurol, Gothenburg, Sweden

 Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden

Terao, C:
 RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan

Thijs, V:
 Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Stroke Theme, Melbourne, Vic, Australia

 Austin Hlth, Dept Neurol, Heidelberg, Vic, Australia

Torres-Aguila, NP:
 Biomed Res Inst St Pau IIB St Pau, Stroke Pharmacogen & Genet Grp, Barcelona, Spain

Tregouet, DA:
 Univ Bordeaux, Inserm Bordeux Populat Hlth Res Ctr, UMR 1219, Bordeaux, France

Tuladhar, AM:
 Radboud Univ Nijmegen Med Ctr, Donders Med Ctr Neurosci, Dept Neurol, Nijmegen, Netherlands

Veldink, JH:
 Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr, Dept Neurol, Utrecht, Netherlands

Walters, RG:
 Univ Oxford, Nuffield Dept Populat Hlth, MRC Populat Hlth Res Unit, Oxford, England

Weir, DR:
 Dept Clin Sci, Malmo, Sweden

Woo, D:
 Univ Cincinnati, Coll Med, Dept Neurol & Rehabil Med, Cincinnati, OH 45221 USA

Worrall, BB:
 Univ Virginia, Sch Med, Dept Neurol, Charlottesville, VA USA

 Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA USA

Hong, CC:
 Univ Maryland, Sch Med, Dept Med, Baltimore, MD USA

Ross, OA:
 Mayo Clin, Dept Neurol, Jacksonville, FL USA

Zand, R:
 Geisinger Hlth Syst, Dept Mol & Funct Genom, Danville, PA USA

de Leeuw, FE:
 Radboud Univ Nijmegen Med Ctr, Donders Med Ctr Neurosci, Dept Neurol, Nijmegen, Netherlands

Lindgren, AG:
 Lund Univ, Dept Clin Sci, Neurol, Lund, Sweden

 Skane Univ Hosp, Neurol Sect, Lund, Sweden

Pare, G:
 McMaster Univ, DBCVS Res Inst, Dept Pathol & Mol Med, Populat Hlth Res Inst, Hamilton, ON, Canada

 Thrombosis & Atherosclerosis Res Inst TaARI, Hamilton, ON, Canada

Anderson, CD:
 Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA USA

 Harvard Med Sch, Brigham & Womens Hosp, Dept Neurol, Boston, MA USA

 Massachusetts Gen Hosp, McCance Ctr Brain Hlth, Boston, MA USA

 Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA

Markus, HS:
 Univ Cambridge, Stroke Res Grp, Cambridge, England

Jern, C:
 Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Lab Med, Gothenburg, Sweden

 Sahlgrens Univ Hosp, Reg Vastra Gotaland, Dept Clin Genet & Genom, Gothenburg, Sweden

Malik, R:
 Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany

Dichgans, M:
 Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany

 Munich Cluster Syst Neurol SyNergy, Munich, Germany

 German Ctr Neurodegenerat Dis DZNE, Munich, Germany

Mitchell, BD:
 Univ Maryland, Sch Med, Div Endocrinol, Baltimore, MD 21201 USA

 Vet Adm Med Ctr, Geriatr Res & Educ Clin Ctr, Baltimore, MD USA

Kittner, SJ:
 Univ Maryland, Dept Neurol, Diabet & Nutr, Baltimore, MD 21201 USA

 Vet Adm Med Ctr, Geriatr Res & Educ Clin Ctr, Baltimore, MD USA

Univ Helsinki, Helsinki, Finland.
Hunter Med Res Inst, Newcastle, NSW, Australia.
Ohio State Univ, Ctr Clin & Translat Sci, Columbus, OH USA.
Univ Newcastle, Newcastle, NSW, Australia.
Univ Newcastle, Prior Res Ctr Stroke & Brain Injury, Newcastle, NSW, Australia.
Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat IMBEI, Mainz, Germany.
Ludwig Maximilians Univ Munchen, Dept Med 1, Munich, Germany.