The Value of the Second QuantiFERON-TB Gold-Plus Antigen Tube at Diagnosis and at Treatment Completion in Spanish Children With Tuberculosis


Por: Soler-García a, Gamell Fullà A, Manuel Monsonis Cabedo, Korta-Murua JJ, Espiau M, Rincón-López E, Rodríguez-Molino P, Pérez-Porcuna T, Bustillo-Alonso M, Santiago B, Tebruegge M and Noguera-Julian A

Publicada: 1 nov 2023 Ahead of Print: 1 ago 2023
Resumen:
We studied 295 children (tuberculosis disease, n = 159; latent tuberculosis infection, n = 136) with positive QuantiFERON-TB Gold-Plus assay results. No significant differences between first and second antigen tube interferon-gamma responses were detected, irrespective of patient and disease characteristics at diagnosis. Of patients with a repeat assay after treatment completion (n = 65), only 16.9% converted to negative results.

Filiaciones:
Soler-García a:
 From the Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Servei de Malalties Infeccioses i Patologia Importada, Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain

Gamell Fullà A:
 From the Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Servei de Malalties Infeccioses i Patologia Importada, Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain

Manuel Monsonis Cabedo:
 Servei de Microbiologia, Hospital Sant Joan de Déu, Barcelona, Spain

Korta-Murua JJ:
 Servicio de Pediatría, Hospital Universitario Donostia-Instituto BioDonostia, Donostia Ospitalea, San Sebastián, Spain

 Departamento de Pediatría, Facultad de Medicina, EHU-UPV, Donostia University Hospital Gipuzkoa Building, San Sebastian, Spain

Espiau M:
 Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Barcelona, Spain

Rincón-López E:
 Paediatric Infectious Diseases Unit, Gregorio Marañón Mother and Child Hospital, Madrid, Spain

Rodríguez-Molino P:
 Pediatric Infectious and Tropical Diseases Department, Hospital Universitario La Paz, Madrid, Spain

Pérez-Porcuna T:
 Atenció Primària, Fundació Assistencial Mútua de Terrassa, Terrassa, Spain

 Unitat de Salut Internacional, Departament de Pediatria, Fundació Recerca Hospital Universitari Mútua de Terassa, Universitat de Barcelona, Terrassa, Spain

Bustillo-Alonso M:
 Pediatrics Department, Miguel Servet University Hospital, Zaragoza, Spain

Santiago B:
 Paediatric Infectious Diseases Unit, Gregorio Marañón Mother and Child Hospital, Madrid, Spain

 Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain

 Red de Investigación Translacional en Infectología Pediátrica (RITIP), Madrid, Spain

Tebruegge M:
 Department of Paediatrics, Klinik Ottakring, Wiener Gesundheitsverbund, Vienna, Austria

 Department of Paediatrics, Royal Children's Hospital Melbourne, University of Melbourne, Melbourne, Australia

 Department of Infection, Immunity & Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom

Noguera-Julian A:
 From the Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Servei de Malalties Infeccioses i Patologia Importada, Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain

 Paediatric Infectious Diseases Unit, Gregorio Marañón Mother and Child Hospital, Madrid, Spain

 Departament de Cirurgia i Especialitats Medicoquirúrgiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain

 and

 Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain

Azurmendi-Gundín N:
 Hospital Universitario Donostia-Instituto BioDonostia San Sebastián, Spain

Fortuny-Guasch C:
 Hospital Sant Joan de Déu Barcelona, Spain

Colino E:
 Complejo Hospitalario Universitario Insular Materno Infantil de Las Palmas de Gran Canaria Las Palmas de Gran Canaria, Spain

Gómez-Pastrana D:
 Hospital de Jerez de la Frontera Jerez de la Frontera, Spain

Montero M:
 Hospital Puerta del Mar Cádiz, Spain

Peromingo E:
 Hospital Puerta del Mar Cádiz, Spain

Lafuente-Hidalgo M:
 Hospital Universitario Miguel Servet Zaragoza, Spain

Moliner E:
 Hospital Sant Pau Barcelona, Spain

Valmanya T:
 Hospital Arnau de Vilanova Lleida, Spain

Minguell-Domingo L:
 Hospital Arnau de Vilanova Lleida, Spain

Fenoy M:
 Hospital Consorci de Terrassa Terrassa, Spain

Velázquez M:
 Hospital Consorci de Terrassa Terrassa, Spain

Soler-Campins MQ:
 Hospital Consorci de Terrassa Terrassa, Spain

Garcia L:
 Hospital de Mataró Mataró, Spain

Lahoz R:
 Hospital Joan XXIII Tarragona, Spain

Calavia O:
 Hospital Joan XXIII Tarragona, Spain

Pascual MT:
 Hospital Sant Joan Reus, Spain

Rius N:
 Hospital Sant Joan Reus, Spain

Tórtola T:
 Hospital Vall d´Hebron Barcelona, Spain

Soriano-Arandes A:
 Hospital Vall d´Hebron Barcelona, Spain

Martín-Nalda A:
 Hospital Vall d´Hebron Barcelona, Spain

Soler-Palacín P:
 Hospital Vall d´Hebron Barcelona, Spain

Lillo M:
 Hospital de Albacete Albacete, Spain

Dapena M:
 Hospital General de Castelló Castelló de la Plana, Spain

López-Medina EM:
 Hospital la Fe Valencia, Spain

Piqueras AI:
 Hospital la Fe Valencia, Spain

Ruiz-Jiménez M:
 Hospital de Getafe Getafe, Spain

Soto-Sánchez B:
 Hospital de Getafe Getafe, Spain

Hernández Á:
 Hospital Universitario Gregorio Marañón Madrid, Spain

Ruiz-Serrano MJ:
 Hospital Universitario Gregorio Marañón Madrid, Spain

Cobo-Vázquez E:
 Hospital Universitario Gregorio Marañón Madrid, Spain

Santos MDM:
 Hospital Universitario Gregorio Marañón Madrid, Spain

Hernández-Sampelayo T:
 Hospital Universitario Gregorio Marañón Madrid, Spain

Tagarro A:
 Hospital Infanta Sofía Madrid, Spain

Méndez-Echevarría A:
 Hospital La Paz Madrid, Spain

Mellado MJ:
 Hospital La Paz Madrid, Spain

Baquero-Artigao F:
 Hospital La Paz Madrid, Spain

Calvo C:
 Hospital La Paz Madrid, Spain

Sainz T:
 Hospital La Paz Madrid, Spain

Álvarez J:
 Hospital del Niño Jesús Madrid, Spain

García Ascaso MT:
 Hospital del Niño Jesús Madrid, Spain

Villalobos E:
 Hospital del Niño Jesús Madrid, Spain

Pérez-Gorricho B:
 Hospital del Niño Jesús Madrid, Spain

García-García ML:
 Hospital Severo Ochoa Madrid, Spain

Garrote-Llanos MI:
 Hospital de Basurto Bilbao, Spain

Rementería J:
 Hospital de Basurto Bilbao, Spain

Sánchez-Torrent L:
 Hospital de Sant Boi, Sant Boi de Llobregat Spain

García-Hortelano M:
 Instituto de Salud Carlos III Madrid, Spain

Lobato Z:
 Hospital Sant Joan de Déu - Fundació Althaia Manresa, Spain
ISSN: 08913668





PEDIATRIC INFECTIOUS DISEASE JOURNAL
Editorial
LIPPINCOTT WILLIAMS & WILKINS, TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103, Estados Unidos America
Tipo de documento: Article
Volumen: 42 Número: 11
Páginas: 1017-1020
WOS Id: 001086833500030
ID de PubMed: 37566889
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