The polygenic basis of relapse after a first episode of schizophrenia.
Por:
Segura ÀG, Prohens L, Gassó P, Rodríguez N, Garcia-Rizo C, Moreno-Izco L, Andreu-Bernabeu Á, Zorrilla I, Mane A, Rodriguez-Jimenez R, Roldán A, Sarró S, Ibáñez Á, Usall J, Sáiz PA, Cuesta MJ, Parellada M, González-Pinto A, Berrocoso E, Bernardo M, Mas S, Mezquida G, Arbelo N, De Matteis M, Galvañ J, Duque Guerra A, Arias I Queralt L, Perez-Bacigalupe M, Gonzalez-Ortega I, Toll A, Casanovas F, Sanchez-Pastor L, Valtueña M, Pomarol-Clotet E, García-León MÁ, Butjosa A, Rubio E, Ribeiro M, López-Ilundain JM, Saiz-Ruiz J, León-Quismondo L, Rivero O, Ruiz P, Echevarría RS and García-Portilla MP
Publicada:
1 oct 2023
Ahead of Print:
19 ago 2023
Resumen:
Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRS-EA, showed both a lower risk (OR=0.29, 95% CI [0.11-0.73]) and a later onset of relapse (30.96± 1.74 vs. 23.12± 1.14 months, p=0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse.
Filiaciones:
Segura ÀG:
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Prohens L:
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Gassó P:
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Rodríguez N:
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Garcia-Rizo C:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Barcelona Clínic Schizophrenia Unit (BCSU), Hospital Clínic de Barcelona, Neuroscience Institute, Barcelona, Spain
Department of Medicine, University of Barcelona, Barcelona, Spain
Moreno-Izco L:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, Hospital Universitario de Navarra, Pamplona, Spain
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
Andreu-Bernabeu Á:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain
School of Medicine, Universidad Complutense, Madrid, Spain
Zorrilla I:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, BIOARABA Health Research Institute Vitoria, Hospital Universitario de Alava, Spain
University of the Basque Country, Vitoria, Spain
Mane A:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Hospital del Mar, Medical Research Institute (IMIM), Barcelona, Spain
Rodriguez-Jimenez R:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Universidad Complutense de Madrid (UCM), Madrid, Spain
Department of Psychiatry. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain
Roldán A:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Sarró S:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Ibáñez Á:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
Alcalá de Henares, Universidad de Alcalá, Spain
Usall J:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain
Sáiz PA:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, University of Oviedo, Oviedo, Spain
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA). Instituto de Neurociencias del Principado de Asturias (INEUROPA). Mental Health Services of the Principality of Asturias (SESPA), Oviedo, Spain
Cuesta MJ:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, Hospital Universitario de Navarra, Pamplona, Spain
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
Parellada M:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain
School of Medicine, Universidad Complutense, Madrid, Spain
González-Pinto A:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, BIOARABA Health Research Institute Vitoria, Hospital Universitario de Alava, Spain
University of the Basque Country, Vitoria, Spain
Berrocoso E:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Neuropsychopharmacology and Psychobiology Research Group, Department of Psychology, University of Cádiz, Cádiz, Spain
Instituto de Investigación e Innovación Biomédica de Cádiz, INiBICA, Hospital Universitario Puerta del Mar, Cádiz, Spain
Bernardo M:
Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Barcelona Clínic Schizophrenia Unit (BCSU), Hospital Clínic de Barcelona, Neuroscience Institute, Barcelona, Spain
Department of Medicine, University of Barcelona, Barcelona, Spain
Mas S:
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Mezquida G:
Department of Clinical Foundations, Pharmacology Unit, University of Barcelona, Barcelona, Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Barcelona Clínic Schizophrenia Unit (BCSU), Hospital Clínic de Barcelona, Neuroscience Institute, Barcelona, Spain
Arbelo N:
Barcelona Clínic Schizophrenia Unit (BCSU), Hospital Clínic de Barcelona, Neuroscience Institute, Barcelona, Spain
De Matteis M:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain
School of Medicine, Universidad Complutense, Madrid, Spain
Galvañ J:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, Madrid, Spain
School of Medicine, Universidad Complutense, Madrid, Spain
Duque Guerra A:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Arias I Queralt L:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, Institut d'Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
Perez-Bacigalupe M:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, BIOARABA Health Research Institute Vitoria, Hospital Universitario de Alava, Spain
University of the Basque Country, Vitoria, Spain
Gonzalez-Ortega I:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, BIOARABA Health Research Institute Vitoria, Hospital Universitario de Alava, Spain
University of the Basque Country, Vitoria, Spain
Toll A:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Hospital del Mar, Medical Research Institute (IMIM), Barcelona, Spain
Casanovas F:
Hospital del Mar, Medical Research Institute (IMIM), Barcelona, Spain
Sanchez-Pastor L:
Department of Psychiatry. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain
Valtueña M:
Department of Psychiatry. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain
Pomarol-Clotet E:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
García-León MÁ:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
Butjosa A:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain
Rubio E:
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Spain
Ribeiro M:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, Hospital Universitario de Navarra, Pamplona, Spain
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
López-Ilundain JM:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, Hospital Universitario de Navarra, Pamplona, Spain
Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
Saiz-Ruiz J:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
Alcalá de Henares, Universidad de Alcalá, Spain
León-Quismondo L:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
Alcalá de Henares, Universidad de Alcalá, Spain
Rivero O:
Biomedical Research Institute INCLIVA, Fundación Investigación Hospital Clínico de Valencia, Valencia, Spain
Departament of Genetics, Universitat de València, Valencia, Spain
Ruiz P:
Hospital Clínico Universitario and Instituto de Investigación Sanitaria (IIS) Aragón, Zaragoza, Spain
Department of Medicine and Psychiatry.Universidad de Zaragoza, Zaragoza, Spain
Echevarría RS:
Cruces University Hospital, BioCruces Health Research Institute, Vizcaya, Spain
University of the Basque Country (UPV/EHU) Vizcaya, Spain
García-Portilla MP:
Centro de Investigación Biomédica en red en salud Mental (CIBERSAM), Spain
Department of Psychiatry, University of Oviedo, Oviedo, Spain
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA). Instituto de Neurociencias del Principado de Asturias (INEUROPA). Mental Health Services of the Principality of Asturias (SESPA), Oviedo, Spain
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