Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices
Por:
Garcia-Mintegui C, Ivan, Goncharov, Laia, Ortiz-Membrado, Emilio, Jimenez-Pique, Ginebra MP, Maurizio, Vedani, Luis, Cortina Jose and Pegueroles M
Publicada:
1 abr 2023
Ahead of Print:
1 mar 2023
Resumen:
Actual polymeric wound closure devices are not optimal for load-bearing
applications due to the low mechanical properties and the risk of
inflammation and bacterial infection mainly produced by multifil-ament
and braided configurations. Biodegradable metallic Zn alloys are
promising materials candidates; however, mechanical performance,
corrosion behaviour, and biological response should be controlled in
order to inhibit the risk of inflammation and bacterial infection. To
this end, a Zn-2Ag (2 wt% Ag) alloy was processed by ECAP to evaluate
the concurrent combined effect of grain refinement and Ag alloying on
biodegradation and antibacterial activity. Two ECAP cycles were
successfully applied to a Zn-2Ag alloy obtaining a homogeneous
ultra-fine-grained structure in which nanoindentation maps suggested
isotro-pic mechanical properties. Lower UTS and YS with higher
elongation was reported after ECAP with similar corrosion rates as
before processing. ECAP processed samples showed a homogeneous Ag+
release below the minimum inhibitory concentration for S. Aureus and no
antibacterial effect was observed by diffusion. As expected, the
presence of Ag in Zn-Ag alloys reduced bacterial attachment.
Nevertheless, ECAP processed Zn-2Ag provided an excellent antibacterial
activity after 3 h probably caused by the uniformly degraded and thus,
non- stable, surface observed after bacterial adhesion.(c) 2023 The
Authors. Published by Elsevier Ltd. This is an open access article under
the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).
Filiaciones:
Garcia-Mintegui C:
Univ Politecn Catalunya UPC, Barcelona East Sch Engn EEBE, Dept Mat Sci & Engn, Biomat Biomech & Tissue Engn Grp, Barcelona 08019, Spain
UPC, Resource Recovery & Environm Management Grp, EEBE, Barcelona 08019, Spain
UPC, Barcelona Res Ctr Multiscale Sci & Engn, EEBE, Barcelona 08019, Spain
Ivan, Goncharov:
Politecn Milan, Dept Mech Engn, I-20156 Milan, Italy
Laia, Ortiz-Membrado:
UPC, Dept Mat Sci & Engn, Struct Integr Micromech & Reliabil Mat Grp, EEBE, Barcelona 08019, Spain
Emilio, Jimenez-Pique:
UPC, Barcelona Res Ctr Multiscale Sci & Engn, EEBE, Barcelona 08019, Spain
UPC, Dept Mat Sci & Engn, Struct Integr Micromech & Reliabil Mat Grp, EEBE, Barcelona 08019, Spain
Ginebra MP:
Univ Politecn Catalunya UPC, Barcelona East Sch Engn EEBE, Dept Mat Sci & Engn, Biomat Biomech & Tissue Engn Grp, Barcelona 08019, Spain
UPC, Barcelona Res Ctr Multiscale Sci & Engn, EEBE, Barcelona 08019, Spain
Inst Bioengn Catalonia IBEC, Barcelona 08028, Spain
Maurizio, Vedani:
Politecn Milan, Dept Mech Engn, I-20156 Milan, Italy
Luis, Cortina Jose:
UPC, Resource Recovery & Environm Management Grp, EEBE, Barcelona 08019, Spain
UPC, Barcelona Res Ctr Multiscale Sci & Engn, EEBE, Barcelona 08019, Spain
Pegueroles M:
Univ Politecn Catalunya UPC, Barcelona East Sch Engn EEBE, Dept Mat Sci & Engn, Biomat Biomech & Tissue Engn Grp, Barcelona 08019, Spain
UPC, Barcelona Res Ctr Multiscale Sci & Engn, EEBE, Barcelona 08019, Spain
Green Published, gold
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