Redefining biomaterial biocompatibility: challenges for artificial intelligence and text mining.
Por:
Mateu-Sanz, Miguel, Fuenteslópez CV, Uribe-Gomez J, Haugen HJ, Pandit A, Ginebra MP, Hakimi O, Krallinger M and Samara A
Publicada:
1 abr 2024
Ahead of Print:
17 oct 2023
Resumen:
The surge in 'Big data' has significantly influenced biomaterials research and development, with vast data volumes emerging from clinical trials, scientific literature, electronic health records, and other sources. Biocompatibility is essential in developing safe medical devices and biomaterials to perform as intended without provoking adverse reactions. Therefore, establishing an artificial intelligence (AI)-driven biocompatibility definition has become decisive for automating data extraction and profiling safety effectiveness. This definition should both reflect the attributes related to biocompatibility and be compatible with computational data-mining methods. Here, we discuss the need for a comprehensive and contemporary definition of biocompatibility and the challenges in developing one. We also identify the key elements that comprise biocompatibility, and propose an integrated biocompatibility definition that enables data-mining approaches.
Filiaciones:
Mateu-Sanz, Miguel:
Biomaterials, Biomechanics, and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya, Barcelona 08019, Spain
Fuenteslópez CV:
Institute of Biomedical Engineering, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford OX3 7LD, UK
Uribe-Gomez J:
CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway H92 W2TY, Ireland
Haugen HJ:
Department of Biomaterials, Center for Functional Tissue Reconstruction, Faculty of Dentistry, University of Oslo, Oslo 0317, Norway
Pandit A:
CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway H92 W2TY, Ireland
Ginebra MP:
Biomaterials, Biomechanics, and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya, Barcelona 08019, Spain
Hakimi O:
aMoon Ventures, Yerushalaim Rd 34, Ra'anana 4350108, Israel
Krallinger M:
Barcelona Supercomputing Center, Barcelona 08034, Spain
Samara A:
Department of Biomaterials, Center for Functional Tissue Reconstruction, Faculty of Dentistry, University of Oslo, Oslo 0317, Norway
Open Access
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