Intrinsic functional brain connectivity changes following aerobic exercise, computerized cognitive training, and their combination in physically inactive healthy late-middle-aged adults: the Projecte Moviment
Por:
Dimitriadis SI, Castells Sánchez Alba, Roig-Coll F, Dacosta-Aguayo R, Lamonja-Vicente N, Torán-Monserrat P, García-Molina A, Monte-Rubio G, Stillman C, Perera A and Mataró-Serrat M
Publicada:
1 feb 2024
Ahead of Print:
1 oct 2023
Resumen:
Lifestyle interventions have positive neuroprotective effects in aging. However, there are still open questions about how changes in resting-state functional connectivity (rsFC) contribute to cognitive improvements. The Projecte Moviment is a 12-week randomized controlled trial of a multimodal data acquisition protocol that investigated the effects of aerobic exercise (AE), computerized cognitive training (CCT), and their combination (COMB). An initial list of 109 participants was recruited from which a total of 82 participants (62% female; age = 58.38 +/- 5.47) finished the intervention with a level of adherence > 80%. Only in the COMB group, we revealed an extended network of 33 connections that involved an increased and decreased rsFC within and between the aDMN/pDMN and a reduced rsFC between the bilateral supplementary motor areas and the right thalamus. No global and especially local rsFC changes due to any intervention mediated the cognitive benefits detected in the AE and COMB groups. Projecte Moviment provides evidence of the clinical relevance of lifestyle interventions and the potential benefits when combining them.
Filiaciones:
Dimitriadis SI:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain.
Institut de Neurociències, University of Barcelona, Barcelona, Spain.
Castells Sánchez Alba:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Roig-Coll F:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Dacosta-Aguayo R:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Institut d'Investigació en Ciències de La Salut Germans Trias I Pujol (IGTP), Badalona, Spain
Lamonja-Vicente N:
Department of Clinical Psychology and Psychobiology, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain
Institut de Neurociències, University of Barcelona, Barcelona, Spain
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain
Torán-Monserrat P:
Unitat de Suport a la Recerca Metropolitana Nord, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina, Mataró, Spain
Department of Medicine, Universitat de Girona, Girona, Spain
García-Molina A:
Institut d'Investigació en Ciències de La Salut Germans Trias I Pujol (IGTP), Badalona, Spain
Institut Guttmann, Institut Universitari de Neurorehabilitació, Universitat Autònoma de Barcelona, Badalona, Spain
Monte-Rubio G:
Centre for Comparative Medicine and Bioimage (CMCiB), Germans Trias I Pujol Research Institute (IGTP), Badalona, Spain
Stillman C:
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
Perera A:
B2SLab, Departament d'Enginyeria de Sistemes, CIBER-BBN, Automàtica I Informàtica Industrial, Universitat Politècnica de Catalunya, 08028, Barcelona, Spain
Department of Biomedical Engineering, Institut de Recerca Pediàtrica Hospital Sant Joan de Déu, 08950, Esplugues de Llobregat, Barcelona, Spain
Mataró-Serrat M:
Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain.
Green Submitted, hybrid
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