Childhood and Adolescent Central Nervous System Tumours in Spain: Incidence and Survival over 20 Years: A Historical Baseline for Current Assessment
Por:
Chirlaque MD, Peris-Bonet R, Sánchez A, Cruz-Martínez O, Marcos-Gragera R, Gutiérrez-Ávila G, Quirós-García JR, Almela-Vich F, López de Munain A, Sánchez MJ, Franch-Sureda P, Ardanaz E, Galceran J, Martos C, Salmerón D, Gatta G, Botta L, Cañete A and The Spanish Childhood Cancer Epidemiology Working Group
Publicada:
1 dic 2023
Ahead of Print:
18 dic 2023
Resumen:
Simple Summary Central nervous system (CNS) tumours are highly common solid neoplasms in children and adolescents. Survival remains low in many countries, including Spain. While some studies have shown a rise in the incidence of these tumours in Europe, others have not. This study, the first in Spain, focused on two questions: (1) Is the incidence of CNS tumours increasing in Spanish children and adolescents? and (2) Has the survival of these patients improved? We analysed incidence in Spain across the period 1983-2007 and survival from 1991 to 2005, according to the International Childhood Cancer Classification. The incidence results revealed a stabilisation in children's overall incidence trend since the early 1990s similar to that of Southern Europe. Overall survival was lower than that in Europe, without any improvement from 1991 to 2005. Our results provide a baseline for assessing current incidence and the achievements of paediatric oncology with regard to CNS tumours in children and adolescents.Abstract Background: Central nervous system (CNS) neoplasms are highly frequent solid tumours in children and adolescents. While some studies have shown a rise in their incidence in Europe, others have not. Survival remains limited. We addressed two questions about these tumours in Spain: (1) Is incidence increasing? and (2) Has survival improved? Methods: This population-based study included 1635 children and 328 adolescents from 11 population-based cancer registries with International Classification of Childhood Cancer Group III tumours, incident in 1983-2007. Age-specific and age-standardised (world population) incidence rates (ASRws) were calculated. Incidence time trends were characterised using annual percent change (APC) obtained with Joinpoint. Cases from 1991 to 2005 (1171) were included in Kaplan-Meier survival analyses, and the results were evaluated with log-rank and log-rank for trend tests. Children's survival was age-standardised using: (1) the age distribution of cases and the corresponding trends assessed with Joinpoint; and (2) European weights for comparison with Europe. Results: ASRw 1983-2007: children: 32.7 cases/106; adolescents: 23.5 cases/106. The overall incidence of all tumours increased across 1983-2007 in children and adolescents. Considering change points, the APCs were: (1) children: 1983-1993, 4.3%<<^>> (1.1; 7.7); 1993-2007, -0.2% (-1.9; 1.6); (2) adolescents: 1983-2004: 2.9%<<^>> (0.9; 4.9); 2004-2007: -7.7% (-40; 41.9). For malignant tumours, the trends were not significant. 5-year survival was 65% (1991-2005), with no significant trends (except for non-malignant tumours). Conclusions: CNS tumour incidence in Spain was found to be similar to that in Europe. Rises in incidence may be mostly attributable to changes in the registration of non-malignant tumours. The overall malignant CNS tumour trend was compatible with reports for Southern Europe. Survival was lower than in Europe, without improvement over time. We provide a baseline for assessing current paediatric oncology achievements and incidence in respect of childhood and adolescent CNS tumours.
Filiaciones:
Chirlaque MD:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Department of Epidemiology, Murcia Regional Health Authority, 30071 Murcia, Spain
Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, El Palmar, 30120 Murcia, Spain
Peris-Bonet R:
Spanish Registry of Childhood Tumours (RETI-SEHOP), University of Valencia, Faculty of Medicine, 46010 Valencia, Spain
Sánchez A:
Department of Epidemiology, Murcia Regional Health Authority, 30071 Murcia, Spain
Cruz-Martínez O:
Neuro-Oncology Unit, Paediatric Cancer Centre, Sant Joan de Déu Hospital, Esplugues de Llobregat, 08950 Barcelona, Spain
Marcos-Gragera R:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Epidemiology Unit and Girona Cancer Registry, Oncology Co-Ordination Plan, Catalonian Oncology Institute, 17004 Girona, Spain
Josep Trueta Girona Biomedical Research Institute (IDIBGI), Salt, 17190 Girona, Spain
Statistics, Econometrics and Health Research Group (GRECS), University of Girona, 17004 Girona, Spain
Josep Carreras Leukaemia Research Institute, 08916 Badalona, Spain
Gutiérrez-Ávila G:
Castile-La Mancha Cancer Registry, Regional Health Authority, 45071 Toledo, Spain
Quirós-García JR:
Asturias Cancer Registry, Public Health Directorate, 33006 Oviedo Asturias, Spain
Almela-Vich F:
Valencian Regional Childhood Cancer Registry, Non-Communicable Disease Epidemiology and Surveillance Department, General Subdirectorate of Epidemiology and Health Surveillance, General Directorate of Public Health and Addictions, Regional Public Health Authority, Valencian Regional Authority, 46010 Valencia, Spain
López de Munain A:
Basque Country Cancer Registry, Health Department, Basque Country Regional Authority, 01010 Vitoria-Gasteiz, Spain
Sánchez MJ:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Andalusian School of Public Health (EASP), 18011 Granada, Spain
Granada Bio-Health Research Institute, 18012 Granada, Spain
Franch-Sureda P:
Mallorca Cancer Registry, General Directorate of Public Health and Participation, Balearic Isles Health Research Institute (IdISBa), 07010 Palma de Mallorca, Spain
Ardanaz E:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Navarre Public Health Institute, 31003 Pamplona, Spain
IdiSNA, Navarre Health Research Institute, 31008 Pamplona, Spain
Galceran J:
Tarragona Cancer Registry, Cancer Epidemiology and Prevention Service, Sant Joan de Reus University Teaching Hospital, 43204 Reus, Spain
Pere Virgili Health Research Institute (IISPV), 43204 Reus, Spain
Faculty of Medicine and Health Sciences, Rovira i Virgili University (URV), 43003 Reus, Spain
Martos C:
Rare Diseases Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), 46020 Valencia, Spain
Salmerón D:
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, El Palmar, 30120 Murcia, Spain
Department of Health and Social Sciences, University of Murcia, 30100 Murcia, Spain
Gatta G:
Evaluative Epidemiology Unit, Department of Epidemiology and Data Science, Fondazione IRCCS, Istituto Nazionale dei Tumori, 20133 Milan, Italy
Botta L:
Evaluative Epidemiology Unit, Department of Epidemiology and Data Science, Fondazione IRCCS, Istituto Nazionale dei Tumori, 20133 Milan, Italy
Cañete A:
Spanish Registry of Childhood Tumours (RETI-SEHOP), University of Valencia, Faculty of Medicine, 46010 Valencia, Spain
Paediatric Oncology Department, La Fe Hospital, 46026 Valencia, Spain
Paediatrics, Obstetrics and Gynaecology Department, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain
Green Submitted, gold
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