Relation between task-related activity modulation and cortical inhibitory function in schizophrenia and healthy controls: a TMS-EEG study
Por:
Fernández-Linsenbarth I, Mijancos-Martínez G, Bachiller A, Núñez P, Rodríguez-González V, Beño-Ruiz-de-la-Sierra RM, Roig-Herrero A, Arjona-Valladares A, Poza J, Mañanas MA and Molina V
Publicada:
1 jun 2024
Ahead of Print:
1 ene 2024
Resumen:
Schizophrenia has been associated with a reduced task-related modulation of cortical activity assessed through electroencephalography (EEG). However, to the best of our knowledge, no study so far has assessed the underpinnings of this decreased EEG modulation in schizophrenia. A possible substrate of these findings could be a decreased inhibitory function, a replicated finding in the field. In this pilot study, our aim was to explore the association between EEG modulation during a cognitive task and the inhibitory system function in vivo in a sample including healthy controls and patients with schizophrenia. We hypothesized that the replicated decreased task-related activity modulation during a cognitive task in schizophrenia would be related to a hypofunction of the inhibitory system. For this purpose, 27 healthy controls and 22 patients with schizophrenia (including 13 first episodes) performed a 3-condition auditory oddball task from which the spectral entropy modulation was calculated. In addition, cortical reactivity-as an index of the inhibitory function-was assessed by the administration of 75 monophasic transcranial magnetic stimulation single pulses over the left dorsolateral prefrontal cortex. Our results replicated the task-related cortical activity modulation deficit in schizophrenia patients. Moreover, schizophrenia patients showed higher cortical reactivity following transcranial magnetic stimulation single pulses over the left dorsolateral prefrontal cortex compared to healthy controls. Cortical reactivity was inversely associated with EEG modulation, supporting the idea that a hypofunction of the inhibitory system could hamper the task-related modulation of EEG activity.
Filiaciones:
Fernández-Linsenbarth I:
Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain
Mijancos-Martínez G:
Biomedical Engineering Research Centre (CREB), Department of Automatic Control (ESAII), Polytechnic University of Catalonia, Barcelona, Spain
Institute of Research Sant Joan de Déu, Barcelona, Spain
Bachiller A:
Biomedical Engineering Research Centre (CREB), Department of Automatic Control (ESAII), Polytechnic University of Catalonia, Barcelona, Spain
Institute of Research Sant Joan de Déu, Barcelona, Spain
Núñez P:
Coma Science Group, CIGA-Consciousness, University of Liège, Liège, Belgium
Biomedical Engineering Group, University of Valladolid, Valladolid, Spain
Biomaterials and Nanomedicine (BICER-BBN), CIBER of Bioengineering, Madrid, Spain
Rodríguez-González V:
Biomedical Engineering Group, University of Valladolid, Valladolid, Spain
Biomaterials and Nanomedicine (BICER-BBN), CIBER of Bioengineering, Madrid, Spain
Beño-Ruiz-de-la-Sierra RM:
Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain
Roig-Herrero A:
Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain
Imaging Processing Laboratory, University of Valladolid, Valladolid, Spain
Arjona-Valladares A:
Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain
Poza J:
Biomedical Engineering Group, University of Valladolid, Valladolid, Spain
Biomaterials and Nanomedicine (BICER-BBN), CIBER of Bioengineering, Madrid, Spain
Instituto de Investigación en Matemáticas (IMUCA), University of Valladolid, Valladolid, Spain
Mañanas MA:
Biomedical Engineering Research Centre (CREB), Department of Automatic Control (ESAII), Polytechnic University of Catalonia, Barcelona, Spain
Institute of Research Sant Joan de Déu, Barcelona, Spain
Biomaterials and Nanomedicine (BICER-BBN), CIBER of Bioengineering, Madrid, Spain
Molina V:
Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain. vicente.molina@uva.es
Psychiatry Service, Clinical Hospital of Valladolid, Valladolid, Spain. vicente.molina@uva.es
Neurosciences Institute of Castilla y Léon (INCYL), University of Salamanca, Salamanca, Spain. vicente.molina@uva.es
Green Submitted, Green Accepted, hybrid
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