DNA Methylation Signatures in Paired Placenta and Umbilical Cord Samples: Relationship with Maternal Pregestational Body Mass Index and Offspring Metabolic Outcomes
Por:
Gómez-Vilarrubla, A, Mas-Parés, B, Carreras-Badosa, G, Bonmatí-Santané, A, Martínez-Calcerrada, JM, Niubó-Pallàs, M, de Zegher, F, Ibañez-Toda L, López-Bermejo, A and Bassols-Casadevall J
Publicada:
1 feb 2024
Ahead of Print:
27 ene 2024
Resumen:
An epigenomic approach was used to study the impact of maternal pregestational body mass index (BMI) on the placenta and umbilical cord methylomes and their potential effect on the offspring's metabolic phenotype. DNA methylome was assessed in 24 paired placenta and umbilical cord samples. The differentially methylated CpGs associated with maternal pregestational BMI were identified and the metabolic pathways and the potentially related diseases affected by their annotated genes were determined. Two top differentially methylated CpGs were studied in 90 additional samples and the relationship with the offspring's metabolic phenotype was determined. The results showed that maternal pregestational BMI is associated with the methylation of genes involved in endocrine and developmental pathways with potential effects on type 2 diabetes and obesity. The methylation and expression of HADHA and SLC2A8 genes in placenta and umbilical cord were related to several metabolic parameters in the offspring at 6 years (weight SDS, height SDS, BMI SDS, Delta BW-BMI SDS, FM SDS, waist, SBP, TG, HOMA-IR, perirenal fat; all p < 0.05). Our data suggest that epigenetic analysis in placenta and umbilical cord may be useful for identifying individual vulnerability to later metabolic diseases.
Filiaciones:
Gómez-Vilarrubla, A:
Girona Inst Biomed Res IDIBGI, Maternal Fetal Metab Res Grp, Salt 17190, Spain
Mas-Parés, B:
Girona Inst Biomed Res IDIBGI, Pediat Endocrinol Res Grp, Salt 17190, Spain
Carreras-Badosa, G:
Girona Inst Biomed Res IDIBGI, Pediat Endocrinol Res Grp, Salt 17190, Spain
Bonmatí-Santané, A:
Dr Josep Trueta Hosp, Dept Gynecol, Girona 17007, Spain
Martínez-Calcerrada, JM:
Girona Inst Biomed Res IDIBGI, Maternal Fetal Metab Res Grp, Salt 17190, Spain
Niubó-Pallàs, M:
Girona Inst Biomed Res IDIBGI, Maternal Fetal Metab Res Grp, Salt 17190, Spain
de Zegher, F:
Univ Leuven, Dept Dev & Regenerat, B-3000 Leuven, Belgium
Ibañez-Toda L:
St Joan Deu Childrens Hosp, Pediat Res Inst, Endocrinol, Esplugas de Llobregat 08950, Spain
Hlth Inst Carlos III ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain
López-Bermejo, A:
Girona Inst Biomed Res IDIBGI, Pediat Endocrinol Res Grp, Salt 17190, Spain
Dr Josep Trueta Hosp, Dept Pediat, Girona 17007, Spain
Bassols-Casadevall J:
Girona Inst Biomed Res IDIBGI, Maternal Fetal Metab Res Grp, Salt 17190, Spain
Green Submitted, Green Accepted, gold
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