QuantiFERON-TB reversion in children and adolescents with tuberculosis
Por:
Rodríguez-Molino P, González Sánchez A, Noguera-Julian A, Soler-García a, Martínez Paz P, Méndez-Echevarría A, Baquero-Artigao F, González Muñoz M, Ruíz-Serrano MJ, Manuel Monsonis Cabedo, Sánchez León R, Saavedra-Lozano J, Santiago-García B and Sainz T
Publicada:
21 mar 2024
Ahead of Print:
21 mar 2024
Resumen:
We analyzed 136 children with tuberculosis disease or infection and a positive QuantiFERON-TB (QFT) assay, followed-up for a median of 21 months (0.4-11years). QFT reversed in 16.9% of cases, with significant decreases in TB1 (-1.72 vs. -0.03 IU/ml, p=0.001) and TB2 (-1.65 vs. -0.43 IU/ml, p=0.005) levels compared to non-reverters. We found a higher QFT reversion rate among children under 5 years (25.0% vs 11.9%, p=0.042), and those with TST induration <15mm (29% vs 13.3%, p=0.055). Our data reveal that, although QFT test remained positive in the majority of children, reversion occurred in 16% of cases in a progressive and stable pattern. Younger age and reduced TST induration were associated with QFT reversion.
Filiaciones:
Rodríguez-Molino P:
General Pediatrics, Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain
La Paz Research Institute (IdiPAZ), Madrid, Spain
Universidad Autonoma de Madrid (UAM), Madrid, Spain
Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain
González Sánchez A:
General Pediatrics, Hospital Puerta de Hierro, Madrid, Spain
Noguera-Julian A:
Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Servei de Malalties Infeccioses Patologia Importada, Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain
Departament de Cirurgia i Especialitats Medicoquirúrgiques, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain
Red de Investigación Translacional en Infectología Pediátrica (RITIP), Madrid, Spain
Soler-García a:
Malalties Infeccioses i Resposta Inflamatòria Sistèmica en Pediatria, Servei de Malalties Infeccioses Patologia Importada, Institut de Recerca Pediàtrica Sant Joan de Déu, Barcelona, Spain
Martínez Paz P:
General Pediatrics, Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain
Méndez-Echevarría A:
General Pediatrics, Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain
La Paz Research Institute (IdiPAZ), Madrid, Spain
Universidad Autonoma de Madrid (UAM), Madrid, Spain
Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain
Baquero-Artigao F:
General Pediatrics, Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain
La Paz Research Institute (IdiPAZ), Madrid, Spain
Universidad Autonoma de Madrid (UAM), Madrid, Spain
Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain
González Muñoz M:
Department of Immunology, Hospital La Paz, Madrid, Spain
Ruíz-Serrano MJ:
Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañon, Madrid, Spain
Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain
Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Respiratorias - CIBERES, Madrid, Spain
Manuel Monsonis Cabedo:
Servei de Microbiologia, Hospital Sant Joan de Déu, Barcelona, Spain
Sánchez León R:
General Pediatrics, Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain
Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain
Saavedra-Lozano J:
Infectious Diseases Department, General Pediatrics, Hospital Gregorio Marañón, Madrid, Spain
Santiago-García B:
Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain
Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), Madrid, Spain
Infectious Diseases Department, General Pediatrics, Hospital Gregorio Marañón, Madrid, Spain
Sainz T:
General Pediatrics, Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain
La Paz Research Institute (IdiPAZ), Madrid, Spain
Universidad Autonoma de Madrid (UAM), Madrid, Spain
Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain
Red de Investigación Translacional en Infectología Pediátrica (RITIP), Madrid, Spain
Green Submitted, gold
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