Vaccinated COVID-19 Index Cases Are Less Likely to Transmit SARS-CoV-2 to Their Household Contacts: A Cohort Study
Por:
Godoy P, Martínez-Baz I, Parron I, García-Cenoz M, Ferras J, Carol M, Bes N, Guillaumes M, Godoy S, Toledo D, Follia N, Miret C, Pardos J, Alsedà M, Plans-Rubio P, Sanz I, Sala MR, Caylà JA, Mendioroz J, Munoz-Almagro C, Castilla J, Domínguez Á and On Behalf Of The Sars-CoV-Transmission To Household Contacts Working Group
Publicada:
1 mar 2024
Ahead of Print:
26 feb 2024
Resumen:
The aim of this study was to evaluate the impact of index case vaccination on SARS-CoV-2 transmission to household contacts. In our epidemiological cohort study (May 2022-November 2023), we surveyed registered index case vaccination status and test results for contacts (testing on day 0, and on day 7 for negative contacts) and calculated the secondary attack rate (SAR), i.e., newly infected contacts/susceptible included contacts. The association of the independent variable, index case COVID-19 vaccination (yes/no), with household contact infection was determined using the adjusted odds ratio (aOR) and its 95% confidence interval (CI). We recorded 181 index cases and 314 contacts, of whom 250 agreed to participate; 16 contacts were excluded upon testing positive on day 0. Of the 234 included contacts, 49.1% were women, and the mean (SD) age was 51.9 (19.8) years. The overall SAR of 37.2% (87/234) was lower in the contacts of both vaccinated index cases (34.9% vs. 63.2%; p = 0.014) and index cases with a previous SARS-CoV-2 infection history (27.0% vs. 46.3%; p = 0.002). Index case vaccination showed a protective effect against infection for their household contacts (aOR = 0.21; 95% CI: 0.07, 0.67). The household SAR was high when the Omicron variant circulated. Vaccinated index cases were less likely to transmit SARS-CoV-2 to their contacts.
Filiaciones:
Godoy P:
Institut de Recerca Biomédica (IRB Lleida), Universitat de Lleida, 25006 Lleida, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
Martínez-Baz I:
CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
Instituto de Salud Pública de Navarra-IdiSNA, 31008 Pamplona, Spain
Parron I:
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
García-Cenoz M:
CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
Instituto de Salud Pública de Navarra-IdiSNA, 31008 Pamplona, Spain
Ferras J:
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
Carol M:
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
Bes N:
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
Guillaumes M:
Agència de Salut Pública de Barcelona, 08023 Barcelona, Spain
Godoy S:
Institut de Recerca Biomédica (IRB Lleida), Universitat de Lleida, 25006 Lleida, Spain
Institut Català de la Salut (ICS), 08007 Lleida, Spain
Toledo D:
CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
Departament de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
Follia N:
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
Miret C:
Institut de Recerca Biomédica (IRB Lleida), Universitat de Lleida, 25006 Lleida, Spain
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
Pardos J:
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
Alsedà M:
Institut de Recerca Biomédica (IRB Lleida), Universitat de Lleida, 25006 Lleida, Spain
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
Plans-Rubio P:
CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
Sanz I:
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
Sala MR:
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
Caylà JA:
Barcelona Tuberculosis Research Unit Foundation, 08008 Barcelona, Spain
Mendioroz J:
Agència de Salut Publica de Catalunya, 08005 Barcelona, Spain
Munoz-Almagro C:
CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
Laboratorio de Microbiología, Hospital Sant Joan de Déu, 08950 Barcelona, Spain
Castilla J:
CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
Instituto de Salud Pública de Navarra-IdiSNA, 31008 Pamplona, Spain
Domínguez Á:
CIBER de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
Departament de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain
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