Glyoxal crosslinking of electro-responsive alginate-based hydrogels: Effects on the properties.
Por:
Colombi S, Sáez I, Borras N, Estrany F, Pérez-Madrigal MM, García-Torres JM, Morgado J and Alemán C
Publicada:
1 ago 2024
Ahead of Print:
15 abr 2024
Resumen:
To improve the features of alginate-based hydrogels in physiological conditions, Ca(2+)-crosslinked semi-interpenetrated hydrogels formed by poly(3,4-ethylenedioxythiophene):polystyrene sulfonic acid and alginate (PEDOT/Alg) were subjected to a treatment with glyoxal to form a dual ionic/covalent network. The covalent network density was systematically varied by considering different glyoxalization times (t(G)). The content of Ca(2+) was significantly higher for the untreated hydrogel than for the glyoxalized ones, while the properties of the hydrogels were found to largely depend on t(G). The porosity and swelling capacity decreased with increasing t(G), while the stiffness and electrical conductance retention capacity increased with t(G). The potentiodynamic response of the hydrogels notably depended on the amount of conformational restraints introduced by the glyoxal, which is a very short crosslinker. Thus, the re-accommodation of the polymer chains during the cyclic potential scans became more difficult with increasing number of covalent crosslinks. This information was used to improve the performance of untreated PEDOT/Alg as electrochemical sensor of hydrogen peroxide by simply applying a t(G) of 5 min. Overall, the control of the properties of glyoxalized hydrogels through t(G) is very advantageous and can be used as an on-demand strategy to improve the performance of such materials depending on the application.
Filiaciones:
Colombi S:
IMEM-BRT Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
Sáez I:
IMEM-BRT Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
Borras N:
IMEM-BRT Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
Estrany F:
IMEM-BRT Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
Pérez-Madrigal MM:
IMEM-BRT Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
García-Torres JM:
Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
Morgado J:
Department of Bioengineering, Instituto de Telecomunicações, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
Alemán C:
IMEM-BRT Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya - BarcelonaTech, C/ Eduard Maristany 10-14, 08019 Barcelona, Spain
Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Baldiri Reixac 10-12, 08028 Barcelona, Spain
Open Access
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