Inflammatory biomarkers and psychological variables to assess quality of life in patients with inflammatory bowel disease: a cross-sectional study
Por:
González-Moret R, Cebolla-Martí A, Almodóvar-Fernández I, Navarrete J, García-Esparza Á, Soria JM and Lisón JF
Publicada:
31 dic 2024
Ahead of Print:
31 may 2024
Resumen:
Background: Inflammatory bowel disease (IBD) is a chronic gastrointestinal condition. While inflammatory biomarkers are valuable for diagnosing and monitoring the disease, their correlation with patients' quality of life (QoL) is not well-established. Purpose: This study aims to investigate the correlations between inflammatory biomarkers and the quality of life (QoL) variables of individuals diagnosed with IBD in clinical remission. Methods: The sample of this cross-sectional study included 74 patients (80% women; 45 +/- 11 years old) diagnosed with IBD. Outcome variables included faecal calprotectin (FC), C-reactive protein (CRP), cortisol levels from hair samples, and anxiety and depression assessed using the Hospital Anxiety and Depression Scale (HADS-A and HADS-D, respectively), alongside QoL evaluated with the Inflammatory Bowel Disease Questionnaire 32 (IBDQ-32). Bivariate correlations were calculated using the Pearson correlation coefficient, and stepwise linear regression analyses were conducted to identify independent factors contributing to IBDQ-32 scores. Results: The IBDQ-32 did not significantly correlate with any biomarkers. However, it exhibited a large and statistically significant negative correlation with HADS-A (r = -0.651) and HADS-D (r = -0.611) scores (p < 0.001). Stepwise linear regression analyses indicated that HADS-A was a significant and independent predictor for IBDQ-32 scores (Adjusted R-2 = 0.41, beta = -0.65, p < 0.001). Conclusions: Inflammatory markers such as CRP, FC, or cortisol in hair do not play a decisive role in assessing the QoL of IBD patients. These findings emphasize the significance of considering psychological factors in evaluating and managing QoL in IBD patients in order to identify severity, suggesting that instruments like HADS should be integral to comprehensive patient assessments.
Filiaciones:
González-Moret R:
Department of Nursing and Physiotherapy, Faculty of Health Sciences, University CEU-Cardenal Herrera, CEU Universities, Valencia, Spain
Cebolla-Martí A:
Department of Psychology, Universidad de Valencia, Valencia, Spain
Centre of Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain
Almodóvar-Fernández I:
Nursing Pre-departmental Unit, Universitat Jaume I, Castellón, Spain
Navarrete J:
Teaching, Research & Innovation Unit, Parc Sanitari Sant Joan de Déu, Barcelona, Spain
CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain
García-Esparza Á:
Department of Pharmacy, Faculty of Health Sciences, University CEU-Cardenal Herrera, CEU Universities, Valencia, Spain
Soria JM:
Departament of Biomedical Science, Faculty of Health Sciences, University CEU-Cardenal Herrera, CEU Universities, Valencia, Spain
Institute of Biomedical Sciences, University CEU-Cardenal Herrera, CEU Universities, Valencia, Spain
Lisón JF:
Centre of Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain
Departament of Biomedical Science, Faculty of Health Sciences, University CEU-Cardenal Herrera, CEU Universities, Valencia, Spain
Institute of Biomedical Sciences, University CEU-Cardenal Herrera, CEU Universities, Valencia, Spain
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