Metabolic, Mitochondrial, and Inflammatory Effects of Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate in Asymptomatic Antiretroviral-Naïve People with HIV
Por:
Barroso, Sergio, Guitart-Mampel, Mariona, Garcia-Garcia, Francesc Josep, Canto-Santos, Judith, Valls-Roca, Laura, Andujar-Sanchez, Felix, Vilaseca-Capel, Adria, Tobias, Ester, Arias-Dimas, Angela, Quesada-Lopez, Tania, Artuch-Iriberri R, Villarroya-Gombau F, Giralt, Marta, Martinez, Esteban, Lozano, Ester and Garrabou, Gloria
Publicada:
1 ago 2024
Ahead of Print:
1 ago 2024
Resumen:
This study aimed to comprehensively assess the metabolic, mitochondrial, and inflammatory effects of first-line efavirenz, emtricitabine, and tenofovir disoproxil fumarate (EFV/FTC/TDF) single-tablet regimen (STR) relative to untreated asymptomatic HIV infection. To this end, we analyzed 29 people with HIV (PWH) treated for at least one year with this regimen vs. 33 antiretroviral-na & iuml;ve PWH. Excellent therapeutic activity was accompanied by significant alterations in metabolic parameters. The treatment group showed increased plasmatic levels of glucose, total cholesterol and its fractions (LDL and HDL), triglycerides, and hepatic enzymes (GGT, ALP); conversely, bilirubin levels (total and indirect fraction) decreased in the treated cohort. Mitochondrial performance was preserved overall and treatment administration even promoted the recovery of mitochondrial DNA (mtDNA) content depleted by the virus, although this was not accompanied by the recovery in some of their encoded proteins (since cytochrome c oxidase II was significantly decreased). Inflammatory profile (TNF alpha, IL-6), ameliorated after treatment in accordance with viral reduction and the recovery of TNF alpha levels correlated to mtDNA cell restoration. Thus, although this regimen causes subclinical metabolic alterations, its antiviral and anti-inflammatory properties may be associated with partial improvement in mitochondrial function.
Filiaciones:
Univ Barcelona UB, Cellex Inst Invest Biomed August Pi Sunyer IDIBAPS,
Fac Med & Hlth Sci, Inherited Metab Dis & Muscular Disorders Res Lab,
Barcelona 08036, Spain
Hosp Clin Barcelona, Dept Internal Med, Barcelona 08036, Spain
Carlos III Hlth Inst, Spanish Biomed Res Ctr Rare Dis, CIBERER, Madrid
28029, Spain
Inst Recerca St Joan Deu, Dept Clin Biochem, Esplugas de Llobregat
08950, Barcelona, Spain
Univ Barcelona UB, Biomed Inst IBUB, Biochem & Mol Biomed Dept,
Barcelona 08014, Spain
Carlos III Hlth Inst, CIBER Physiopathol Obes & Nutr CIBEROBN, Madrid
Hosp Clin Barcelona, Infect Dis Dept, Barcelona 08036, Spain
Carlos III Hlth Inst, CIBER Infect Dis CIBERINFEC, Madrid 28029, Spain
Univ Barcelona UB, Fac Biol, Dept Cell Biol Physiol & Immunol, Barcelona
08028, Spain
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