Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
Por:
Mínguez B, de los Santos MM, García-Volpe C, Molera C, Paredes-Fuentes AJ, Oliva-Mussara C, Arias A, Rodriguez H, Yubero-Siles D, Tondo M, Santos-Ocaña C, Meavilla-Olivas SM and Artuch-Iriberri R
Publicada:
1 ago 2024
Ahead of Print:
9 ago 2024
Resumen:
Coenzyme Q10 (CoQ) is a ubiquitous lipid with different biological functions. In blood, there is a close relationship between CoQ status and cholesterol, which strongly supports the study of both molecules simultaneously. The objective of this study was to evaluate plasma CoQ, lipoprotein concentrations and CoQ/Chol ratio in a cohort of paediatric patients with different types of dyslipidaemias. A total of 60 paediatric patients were recruited (age range: 7 months-18 years), including 52 with different types of hypercholesterolemia, 2 with isolated hypertriglyceridemia and 6 with hypobetalipoproteinemia. Plasma CoQ was analysed by HPLC with electrochemical detection, and lipoprotein and cholesterol concentrations by standard automated methods. The lowest CoQ values were detected in patients with hypobetalipoproteinemia and in two cases of liver cirrhosis. Mean CoQ values were significantly higher in hypercholesterolemic patients compared to controls (average values 1.07 mu mol/L and 0.63 mu mol/L) while the CoQ/cholesterol ratio did not show differences (170 vs. 163, respectively). Mean CoQ values were significantly lower in the group of patients with hypobetalipoproteinemia compared to controls (mean CoQ values of 0.22 mu mol/L vs. 0.63 mu mol/L, respectively), while those of CoQ/cholesterol did not show differences. Pearson's correlation test showed a positive correlation between the CoQ and cholesterol values (r = 0.565, p < 0.001) and between the CoQ and the LDL cholesterol values (r = 0.610, p < 0.001). Our results suggest that it is advisable to analyse plasma CoQ and cholesterol concentrations in patients with hypobetalipoproteinemia and hypercholesterolemia associated with liver damage.
Filiaciones:
Mínguez B:
Gastroenterology and Nutrition Department, Hospital Sant Joan de Déu, 08950 Barcelona, Spain
de los Santos MM:
Gastroenterology and Nutrition Department, Hospital Sant Joan de Déu, 08950 Barcelona, Spain
García-Volpe C:
Gastroenterology and Nutrition Department, Hospital Sant Joan de Déu, 08950 Barcelona, Spain
Molera C:
Gastroenterology and Nutrition Department, Hospital Sant Joan de Déu, 08950 Barcelona, Spain
:
Division of Inborn Errors of Metabolism-IBC, Biochemistry and Molecular Genetics Department, Hospital Clínic de Barcelona, 08036 Barcelona, Spain
Oliva-Mussara C:
Division of Inborn Errors of Metabolism-IBC, Biochemistry and Molecular Genetics Department, Hospital Clínic de Barcelona, 08036 Barcelona, Spain
Arias A:
Clinical Biochemistry Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain
Rodriguez H:
Clinical Biochemistry Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain
Yubero-Siles D:
Genetic Department, Hospital Sant Joan de Déu, 08950 Barcelona, Spain
Tondo M:
Department of Biochemistry, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute (IIB) Sant Pau, 08041 Barcelona, Spain
Centre of Biomedical Investigation Network for Diabetes and Metabolic Diseases (CIBERDEM), 28029 Madrid, Spain
Santos-Ocaña C:
Departamento de Fisiología, Anatomía y Biología Celular, Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, 41013 Sevilla, Spain
U703-U729 CIBERER, Instituto de Salud Carlos III, 28029 Madrid, Spain
Meavilla-Olivas SM:
Gastroenterology and Nutrition Department, Hospital Sant Joan de Déu, 08950 Barcelona, Spain
Artuch-Iriberri R:
Clinical Biochemistry Department, Institut de Recerca Sant Joan de Déu, 08950 Barcelona, Spain
U703-U729 CIBERER, Instituto de Salud Carlos III, 28029 Madrid, Spain
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