Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth
Por:
Knox B, Güil-Oumrait N, Basagaña X, Cserbik D, Dadvand P, Foraster M, Galmes T, Gascon M, Gómez-Roig MD, Gómez-Herrera L, Småstuen Haug L, Llurba E, Márquez S, Rivas I, Sunyer J, Thomsen C, Julia Zanini M, Bustamante M and Vrijheid M
Publicada:
1 nov 2024
Ahead of Print:
1 oct 2024
Resumen:
Introduction: The impact of legacy per- and polyfluoroalkyl substances (PFAS) on fetal growth has been well studied, but assessments of next-generation PFAS and PFAS mixtures are sparse and the potential role of fetoplacental hemodynamics has not been studied. We aimed to evaluate associations between prenatal PFAS exposure and fetal growth and fetoplacental hemodynamics. Methods: We included 747 pregnant women from the BiSC birth cohort (Barcelona, Spain (2018-2021)). Twentythree PFAS were measured at 32 weeks of pregnancy in maternal plasma, of which 13 were present above detectable levels. Fetal growth was measured by ultrasound, as estimated fetal weight at 32 and 37 weeks of gestation, and weight at birth. Doppler ultrasound measurements for uterine (UtA), umbilical (UmA), and middle cerebral artery (MCA) pulsatility indices (PI), as well as the cerebroplacental ratio (CPR - ratio MCA to UmA), were obtained at 32 weeks to assess fetoplacental hemodynamics. We applied linear mixed effects models to assess the association between singular PFAS and longitudinal fetal growth and PI, and Bayesian Weighted Quantile Sum models to evaluate associations between the PFAS mixture and the aforementioned outcomes, controlled for the relevant covariates. Results: Single PFAS and the mixture tended to be associated with reduced fetal growth and CPR PI, but few associations reached statistical significance. Legacy PFAS PFOS, PFHpA, and PFDoDa were associated with statistically significant decreases in fetal weight z-score of 0.13 (95%CI (-0.22,-0.04), 0.06 (-0.10, 0.01), and 0.05 (-0.10, 0.00), respectively, per doubling of concentration. The PFAS mixture was associated with a non- statistically significant 0.09 decrease in birth weight z-score (95%CI-0.22, 0.04) per quartile increase. Conclusion: This study suggests that legacy PFAS may be associated with reduced fetal growth, but associations for next generation PFAS and for the PFAS mixture were less conclusive. Associations between PFAS and fetoplacental hemodynamics warrant further investigation.
Filiaciones:
Knox B:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Güil-Oumrait N:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Basagaña X:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Cserbik D:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Dadvand P:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Foraster M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Galmes T:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Gascon M:
Unitat de Suport a la Recerca de la Catalunya Central, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Manresa, Spain
Gómez-Roig MD:
BCNatal, Fetal Medicine Research Center, Hospital Sant Joan de Déu and Hospital Clínic, University of Barcelona, Barcelona, Spain
Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS), RD21/0012/0003, Instituto de Salud Carlos III, Madrid, Spain
Institut de Recerca Sant Joan de Déu, Barcelona, Spain
Gómez-Herrera L:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Småstuen Haug L:
Norwegian Institute of Public Health (NIPH), Department of Food Safety, Oslo, Norway
Llurba E:
Department of Obstetrics and Gynaecology. Institut d'Investigació Biomèdica Sant Pau - IIB Sant Pau. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Primary Care Interventions to Prevent Maternal and Child Chronic Diseases d Developof Perinatal anmental Origin Network (RICORS), RD21/0012/0001, Instituto de Salud Carlos III, Madrid, Spain
Márquez S:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Rivas I:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Sunyer J:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Thomsen C:
Norwegian Institute of Public Health (NIPH), Department of Food Safety, Oslo, Norway
Julia Zanini M:
BCNatal, Fetal Medicine Research Center, Hospital Sant Joan de Déu and Hospital Clínic, University of Barcelona, Barcelona, Spain
Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS), RD21/0012/0003, Instituto de Salud Carlos III, Madrid, Spain
Bustamante M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Vrijheid M:
ISGlobal, Barcelona, Spain
Universitat Pompeu Fabra (UPF), Barcelona, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
Green Submitted, Green Accepted, gold
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