Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.
Por:
Fortea L, Ortuño M, De Prisco M, Oliva V, Albajes-Eizagirre A, Fortea A, Madero S, Solanes A, Vilajosana E, Yao Y, Del Fabro L, Galindo ES, Verdolini N, Farré-Colomés A, Serra-Blasco M, Picó-Pérez M, Lukito S, Wise T, Carlisi C, Arnone D, Kempton M, Hauson AO, Wollman S, Soriano-Mas C, Rubia K, Norman L, Fusar-Poli P, Mataix-Cols D, Valentí M, Via E, Cardoner N, Solmi M, Zhang J, Pan P, Shin JI, Fullana MÀ, Vieta E and Radua J
Publicada:
1 jul 2025
Ahead of Print:
2 nov 2024
Resumen:
BACKGROUND: Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison participants may be confounded by co-occurring disorders. To disentangle disorder-specific GMV correlates, we conducted a large-scale multidisorder meta-analysis using a novel approach that explicitly models co-occurring disorders. METHODS: We systematically reviewed voxel-based morphometry studies indexed in PubMed and Scopus up to January 2023 that compared adults with major mental disorders (anorexia nervosa, schizophrenia spectrum, anxiety, bipolar, major depressive, obsessive-compulsive, and posttraumatic stress disorders plus attention-deficit/hyperactivity, autism spectrum, and borderline personality disorders) with comparison participants. Two authors independently extracted data and assessed quality using the Newcastle-Ottawa Scale. We derived GMV correlates for each disorder using: 1) a multidisorder meta-analysis that accounted for all co-occurring mental disorders simultaneously and 2) separate standard meta-analyses for each disorder in which co-occurring disorders were ignored. We assessed the alterations' extent, intensity (effect size), and specificity (interdisorder correlations and transdiagnostic alterations) for both approaches. RESULTS: We included 433 studies (499 datasets) involving 19,718 patients and 16,441 comparison participants (51% female, ages 20-67 years). We provide GMV correlate maps for each disorder using both approaches. The novel approach, which accounted for co-occurring disorders, produced GMV correlates that were more focal and disorder specific (less correlated across disorders and fewer transdiagnostic abnormalities). CONCLUSIONS: This work offers the most comprehensive atlas of GMV correlates across major mental disorders. Modeling co-occurring disorders yielded more specific correlates, supporting this approach's validity. The atlas NIfTI maps are available online.
Filiaciones:
Fortea L:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Department of Medicine, University of Barcelona, Institute of Neuroscience, Barcelona, Spain
Ortuño M:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Department of Medicine, University of Barcelona, Institute of Neuroscience, Barcelona, Spain
De Prisco M:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Department of Medicine, University of Barcelona, Institute of Neuroscience, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Bipolar and Depressive Disorders Unit, Hospital Clinic, Barcelona, Spain
Oliva V:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Department of Medicine, University of Barcelona, Institute of Neuroscience, Barcelona, Spain
Bipolar and Depressive Disorders Unit, Hospital Clinic, Barcelona, Spain
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy
Albajes-Eizagirre A:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Fortea A:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Department of Medicine, University of Barcelona, Institute of Neuroscience, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Psychiatric and Psychology Service, Hospital Clinic, Barcelona, Spain
Madero S:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Schizophrenia Unit, Hospital Clinic, Barcelona, Spain
Solanes A:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Vilajosana E:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Yao Y:
Department of Psychology, The University of Hong Kong, Hong Kong SAR, China
Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Del Fabro L:
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
Galindo ES:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Verdolini N:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Department of Medicine, University of Barcelona, Institute of Neuroscience, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Bipolar and Depressive Disorders Unit, Hospital Clinic, Barcelona, Spain
Local Health Unit Umbria 1, Department of Mental Health, Mental Health Center of Perugia, Perugia, Italy
Farré-Colomés A:
Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty of Mannheim, Heidelberg University, Mannheim, Germany
Serra-Blasco M:
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
eHealth ICOnnecta't Program and Psycho-Oncology Service, Institut Català d'Oncologia, 08908 L'Hospitalet de Llobregat, Spain
Psycho-oncology and Digital Health Group, Health Services Research in Cancer, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08908 L'Hospitalet del Llobregat, Spain
Picó-Pérez M:
Live and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal
ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castelló de la Plana, Spain
Lukito S:
Department of Child and Adolescent Psychiatry Institute of Psychology, Psychiatry, and Neuroscience, King's College London, London, UK
Wise T:
Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK
Division of the Humanities and Social Sciences, California Institute of Technology, California, CA, USA
Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK
Carlisi C:
Department of Child and Adolescent Psychiatry Institute of Psychology, Psychiatry, and Neuroscience, King's College London, London, UK
Division of Psychology and Language Sciences, University College London, London, UK
Arnone D:
Centre for Affective Disorders, Psychological Medicine, King's College London, London, UK
Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada
Department of Mental Health, The Ottawa Hospital, Ottawa, ON, Canada
Kempton M:
Department of Neuroimaging, Institute of Psychiatry, Psychology & Neurosciences, King's College London, UK
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Hauson AO:
California School of Professional Psychology, San Diego, CA, USA
Department of Psychiatry, University of California, San Diego, CA, USA
Wollman S:
California School of Professional Psychology, San Diego, CA, USA
Soriano-Mas C:
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Department of Psychiatry, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
Department of Social Psychology and Quantitative Psychology, Universitat de Barcelona, Barcelona, Spain
Rubia K:
Department of Child and Adolescent Psychiatry Institute of Psychology, Psychiatry, and Neuroscience, King's College London, London, UK
Norman L:
Department of Child and Adolescent Psychiatry Institute of Psychology, Psychiatry, and Neuroscience, King's College London, London, UK
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
The Social and Behavioral Research Branch, National Human Genome Research Institute, National Institute of Health, BetheSDa, Maryland, USA
Fusar-Poli P:
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology, London, UK
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
Outreach and Support in South London (OASIS) Service, South London and Maudsley NHS Foundation Trust, London, UK
Mataix-Cols D:
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK
Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden
Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden
Valentí M:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Department of Medicine, University of Barcelona, Institute of Neuroscience, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Bipolar and Depressive Disorders Unit, Hospital Clinic, Barcelona, Spain
Via E:
Department of Child and Adolescent Mental Health, Hospital Sant Joan de Déu, Barcelona, Spain
Cardoner N:
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Sant Pau Mental Health Group, Institut d'Investigació Biomèdica Sant Pau (IBB-Sant Pau), Hospital de la Sant Creu i Sant Pau, Universitat Autònoma de Barcelona (UAB), Barcelona, Catalonia, Spain
Solmi M:
Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada
Regional Centre for the Treatment of Eating Disorders and On Track: The Champlain First Episode Psychosis Program, Department of Mental Health, The Ottawa Hospital, Ottawa, ON, Canada
Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program University of Ottawa, Ottawa, ON, Canada
Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany
Zhang J:
State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China
Pan P:
Department of Neurology, Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Affiliated Yancheng Hospital of Southeast University, Yancheng, China
Shin JI:
Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea
Severance Underwood Meta-research Center, Institute of Convergence Science, Yonsei University, Seoul 03722, South Korea
Fullana MÀ:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Psychiatric and Psychology Service, Hospital Clinic, Barcelona, Spain
Vieta E:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Department of Medicine, University of Barcelona, Institute of Neuroscience, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Bipolar and Depressive Disorders Unit, Hospital Clinic, Barcelona, Spain
Psychiatric and Psychology Service, Hospital Clinic, Barcelona, Spain
Radua J:
Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
Department of Medicine, University of Barcelona, Institute of Neuroscience, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain
Green Submitted, Green Published, hybrid
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