Effectiveness of the autumn 2023 COVID-19 vaccine dose in hospital-based healthcare workers: results of the VEBIS healthcare worker vaccine effectiveness cohort study, seven European countries, season 2023/24


Por: Savulescu C, Prats-Uribe A, Brolin K, Uusküla A, Bergin C, Fleming C, Murri R, Zvirbulis V, Zavadska D, Gaio V, Popescu CP, Hrisca R, Cisneros M, Latorre-Millán M, Lohur L, McGrath J, Ferguson L, De Gaetano Donati K, Abolina I, Gravele D, Machado A, Florescu SA, Lazar M, Subirats P, Clusa Cuesta L, Sui J, Kenny C, Santangelo R, Krievins D, Barzdina EA, Valadas Henriques C, Kosa AG, Pohrib SM, Munoz-Almagro C, Milagro A, Bacci S and Nardone A

Publicada: 31 oct 2024
Resumen:
COVID-19 vaccination recommendations include healthcare workers (HCWs). We measured COVID-19 vaccine effectiveness (CVE) of the autumn 2023 dose against laboratory-confirmed SARS-CoV-2 infection in a prospective cohort study of 1,305 HCWs from 13 European hospitals. Overall CVE was 22% (95% CI: -17 to 48), 49% (95% CI: -8 to 76) before and -11% (95% CI: -84 to 34) after the start of BA.2.86/JN.1 pre-dominant circulation. Autumn 2023 COVID-19 vaccina-tion led to a moderate-to-low reduction in SARS-CoV-2 infection incidence in HCWs. Monitoring of CVE is cru-cial for COVID-19 prevention.

Filiaciones:
Savulescu C:
 EpiConcept, Paris, France

 These authors contributed equally to this work and share first authorship. The other co-authors are listed in the alphabetical order of their countries

Prats-Uribe A:
 EpiConcept, Paris, France

 These authors contributed equally to this work and share first authorship. The other co-authors are listed in the alphabetical order of their countries

Brolin K:
 European Centre for Disease Prevention and Control, Stockholm, Sweden

Uusküla A:
 University of Tartu, Institute of Family Medicine and Public Health, Tartu, Estonia

Bergin C:
 Saint James's Hospital, Dublin, Ireland

Fleming C:
 Galway University Hospital, Galway, Ireland

Murri R:
 Fondazione Policlinico Universitario A, Gemelli IRCCS, Rome, Italy

 Università Cattolica del Sacro Cuore, Rome, Italy

Zvirbulis V:
 Pauls Stradins Clinical University Hospital, Riga, Latvia

Zavadska D:
 Children Clinical University Hospital, Riga, Latvia

Gaio V:
 Department of Epidemiology, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal

Popescu CP:
 Victor Babes Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania

 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Hrisca R:
 Central Military Emergency University Hospital "Dr. Carol Davila", Bucharest, Romania

Cisneros M:
 Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain

 Medicine Department, Universitat Internacional de Catalunya, Barcelona, Spain

Latorre-Millán M:
 Research Group on Difficult to Diagnose and Treat Infections, Miguel Servet University Hospital, IIS Aragon, Zaragoza, Spain

Lohur L:
 Viljandi Hospital, Viljandi, Estonia

McGrath J:
 Saint James's Hospital, Dublin, Ireland

Ferguson L:
 Galway University Hospital, Galway, Ireland

De Gaetano Donati K:
 Fondazione Policlinico Universitario A, Gemelli IRCCS, Rome, Italy

 Università Cattolica del Sacro Cuore, Rome, Italy

Abolina I:
 Pauls Stradins Clinical University Hospital, Riga, Latvia

Gravele D:
 Children Clinical University Hospital, Riga, Latvia

Machado A:
 Department of Epidemiology, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal

Florescu SA:
 Victor Babes Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania

 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Lazar M:
 Cantacuzino National Military-Medical Institute for Research and Development, Bucharest, Romania

Subirats P:
 Department of Occupational Risk Prevention, Hospital Sant Joan de Deu, Barcelona, Spain

Clusa Cuesta L:
 Research Group on Difficult to Diagnose and Treat Infections, Miguel Servet University Hospital, IIS Aragon, Zaragoza, Spain

Sui J:
 Saint James's Hospital, Dublin, Ireland

Kenny C:
 Galway University Hospital, Galway, Ireland

Santangelo R:
 Fondazione Policlinico Universitario A, Gemelli IRCCS, Rome, Italy

 Università Cattolica del Sacro Cuore, Rome, Italy

Krievins D:
 Pauls Stradins Clinical University Hospital, Riga, Latvia

Barzdina EA:
 Children Clinical University Hospital, Riga, Latvia

Valadas Henriques C:
 Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal

Kosa AG:
 Victor Babes Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania

Pohrib SM:
 Central Military Emergency University Hospital "Dr. Carol Davila", Bucharest, Romania

Munoz-Almagro C:
 Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, Barcelona, Spain

 Medicine Department, Universitat Internacional de Catalunya, Barcelona, Spain

 CIBER of Epidemiology and Public Health CIBERESP, Madrid, Spain

Milagro A:
 Research Group on Difficult to Diagnose and Treat Infections, Miguel Servet University Hospital, IIS Aragon, Zaragoza, Spain

Bacci S:
 European Centre for Disease Prevention and Control, Stockholm, Sweden

Nardone A:
 EpiConcept, Paris, France

VEBIS HCW VE study group:
 The additional collaborators of the VEBIS HCW VE study group are listed at the end of the article
ISSN: 1025496X





EUROSURVEILLANCE
Editorial
European Centre for Disease Prevention and Control (ECDC), Sweden, Suecia
Tipo de documento: Article
Volumen: 29 Número: 44
Páginas:
WOS Id: 001351160800003
ID de PubMed: 39484687
imagen gold, Green Published

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