Incidence of SARS-CoV-2 Infection Among European Healthcare Workers and Effectiveness of the First Booster COVID-19 Vaccine, VEBIS HCW Observational Cohort Study, May 2021-May 2023
Por:
Savulescu C, Prats-Uribe A, Brolin K, Lovric Makaric Z, Uusküla A, Panagiotakopoulos G, Bergin C, Fleming C, Agodi A, Bonfanti P, Murri R, Zvirbulis V, Zavadska D, Szuldrzynski K, Machado A, Popescu CP, Craiu M, Cisneros M, Latorre-Millán M, Petrovic G, Lohur L, Tryfinopoulou K, McGrath J, Ferguson L, Barchitta M, Spolti A, de Gaetano Donati K, Abolina I, Gravele D, Gaio V, Florescu SA, Lazar M, Subirats P, Clusa Cuesta L, Sarajlic G, Amerali M, Sui J, Kenny C, Rapisarda V, Rossi M, Lamonica S, Krievins D, Barzdina EA, Palmira Amaral A, Kosa AG, Miron VD, Munoz-Almagro C, Milagro AM, Bacci S, Kramarz P, Nardone A and The Vebis Hcw Ve Study Group
Publicada:
1 nov 2024
Ahead of Print:
19 nov 2024
Resumen:
Background: European countries have included healthcare workers (HCWs) among priority groups for COVID-19 vaccination. We established a multi-country hospital network to measure the SARS-CoV-2 incidence and effectiveness of COVID-19 vaccines among HCWs against laboratory-confirmed SARS-CoV-2 infection. Methods: HCWs from 19 hospitals in 10 countries participated in a dynamic prospective cohort study, providing samples for SARS-CoV-2 testing at enrolment and during weekly/fortnightly follow-up. We measured the incidence during pre-Delta (2 May-6 September 2021), Delta (7 September-14 December 2021), and Omicron (15 December 2021-2 May 2023) waves. Using Cox regression, we measured the relative vaccine effectiveness (rVE) of the first COVID-19 booster dose versus primary course alone during Delta and Omicron waves. Results: We included a total of 3015 HCWs. Participants were mostly female (2306; 79%), with a clinical role (2047; 68%), and had a median age of 44 years. The overall incidence of SARS-CoV-2 infection was 3.01/10,000 person-days during pre-Delta, 4.21/10,000 during Delta, and 23.20/10,000 during Omicron waves. rVE was 59% (95% CI: -25; 86) during Delta and 22% (1; 39) during Omicron waves. rVE was 51% (30; 65) 7-90 days after the first booster dose during the Omicron wave. Conclusions: The incidence of SARS-CoV-2 infection among HCWs was higher during the Omicron circulation period. The first COVID-19 vaccine booster provided additional protection against SARS-CoV-2 infection compared to primary course vaccination when recently vaccinated <90 days. This multi-country HCW cohort study addressing infection as the main outcome is crucial for informing public health interventions for HCWs.
Filiaciones:
Savulescu C:
Epiconcept, 75011 Paris, France
Prats-Uribe A:
Epiconcept, 75011 Paris, France
Brolin K:
European Centre for Disease Prevention and Control, 169 73 Solna, Sweden
Lovric Makaric Z:
Croatian Institute of Public Health, 10000 Zagreb, Croatia
Uusküla A:
Institute of Family Medicine and Public Health, University of Tartu, 50090 Tartu, Estonia
Panagiotakopoulos G:
National Public Health Organization (EODY), EL-15123 Athens, Greece
Bergin C:
Department of Genitourinary Medicine and Infectious Diseases (GUIDe), St. James's Hospital, D08 NHY1 Dublin, Ireland
Department of Clinical Medicine, Trinity College, D02 PN40 Dublin, Ireland
Fleming C:
Department of Infectious Diseases, University Hospital Galway, H91 YR71 Galway, Ireland
Department of Medicine, University of Galway, H91 TK33 Dublin, Ireland
Agodi A:
Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95124 Catania, Italy
Azienda Ospedaliero-Universitaria Policlinico AOUP "G. Rodolico-San Marco", 95124 Catania, Italy
Bonfanti P:
Infectious Diseases Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza-University of Milano, Bicocca, 20126 Milano, Italy
Murri R:
Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Dipartimento di Sicurezza e Bioetica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Zvirbulis V:
Pauls Stradins Clinical University Hospital, 1002 Riga, Latvia
Zavadska D:
Children Clinical University Hospital, 1004 Riga, Latvia
Szuldrzynski K:
National Institute of Medicine of the Ministry of Interior and Administration, 02-106 Warsaw, Poland
Machado A:
Department of Epidemiology, National Institute of Health Doutor Ricardo Jorge, 1649-016 Lisbon, Portugal
Popescu CP:
Victor Babes Clinical Hospital of Infectious and Tropical Diseases, 030303 Bucharest, Romania
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Craiu M:
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
National Institute for Mother and Child Care Alessandrescu Rusescu, 20382 Bucharest, Romania
Cisneros M:
Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08950 Barcelona, Spain
Medicine Department, Universitat Internacional de Catalunya, 08195 Barcelona, Spain
Latorre-Millán M:
Research Group on Difficult to Diagnose and Treat Infections, IIS Aragon, Miguel Servet University Hospital, 50009 Zaragoza, Spain
Petrovic G:
Croatian Institute of Public Health, 10000 Zagreb, Croatia
Lohur L:
Outpatient Department, Viljandi Hospital, 71024 Viljandi, Estonia
Tryfinopoulou K:
National Public Health Organization (EODY), EL-15123 Athens, Greece
McGrath J:
Department of Genitourinary Medicine and Infectious Diseases (GUIDe), St. James's Hospital, D08 NHY1 Dublin, Ireland
Ferguson L:
Department of Infectious Diseases, University Hospital Galway, H91 YR71 Galway, Ireland
Barchitta M:
Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95124 Catania, Italy
Spolti A:
Infectious Diseases Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza-University of Milano, Bicocca, 20126 Milano, Italy
de Gaetano Donati K:
Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Dipartimento di Sicurezza e Bioetica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Abolina I:
Pauls Stradins Clinical University Hospital, 1002 Riga, Latvia
Gravele D:
Children Clinical University Hospital, 1004 Riga, Latvia
Gaio V:
Department of Epidemiology, National Institute of Health Doutor Ricardo Jorge, 1649-016 Lisbon, Portugal
Florescu SA:
Victor Babes Clinical Hospital of Infectious and Tropical Diseases, 030303 Bucharest, Romania
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
Lazar M:
Cantacuzino National Military-Medical Institute for Research and Development, 050096 Bucharest, Romania
Subirats P:
Department of Occupational Risk Prevention, Hospital Sant Joan de Deu, 08950 Barcelona, Spain
Clusa Cuesta L:
Research Group on Difficult to Diagnose and Treat Infections, IIS Aragon, Miguel Servet University Hospital, 50009 Zaragoza, Spain
Sarajlic G:
Croatian Institute of Public Health, 10000 Zagreb, Croatia
Amerali M:
National Public Health Organization (EODY), EL-15123 Athens, Greece
Sui J:
Department of Genitourinary Medicine and Infectious Diseases (GUIDe), St. James's Hospital, D08 NHY1 Dublin, Ireland
Kenny C:
Department of Infectious Diseases, University Hospital Galway, H91 YR71 Galway, Ireland
Rapisarda V:
Azienda Ospedaliero-Universitaria Policlinico AOUP "G. Rodolico-San Marco", 95124 Catania, Italy
Department of Clinical and Experimental Medicine, Occupational Medicine, University of Catania, 95124 Catania, Italy
Rossi M:
Infectious Diseases Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza-University of Milano, Bicocca, 20126 Milano, Italy
Lamonica S:
Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Dipartimento di Sicurezza e Bioetica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Krievins D:
Pauls Stradins Clinical University Hospital, 1002 Riga, Latvia
Barzdina EA:
Children Clinical University Hospital, 1004 Riga, Latvia
Palmira Amaral A:
Centro Hospitalar Tondela-Viseu EPE, 3504-509 Viseu, Portugal
Kosa AG:
Victor Babes Clinical Hospital of Infectious and Tropical Diseases, 030303 Bucharest, Romania
Miron VD:
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
National Institute for Mother and Child Care Alessandrescu Rusescu, 20382 Bucharest, Romania
Munoz-Almagro C:
Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08950 Barcelona, Spain
Medicine Department, Universitat Internacional de Catalunya, 08195 Barcelona, Spain
Ciber of Epidemiology and Public Health CIBERESP, 28029 Madrid, Spain
Milagro AM:
Research Group on Difficult to Diagnose and Treat Infections, IIS Aragon, Miguel Servet University Hospital, 50009 Zaragoza, Spain
Bacci S:
European Centre for Disease Prevention and Control, 169 73 Solna, Sweden
Kramarz P:
European Centre for Disease Prevention and Control, 169 73 Solna, Sweden
Nardone A:
Epiconcept, 75011 Paris, France
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