Cancer and the 10-Year Incidence of Chronic Low Back Pain in 407,314 Adults Followed in General Practices in Germany
Por:
Kostev K, Latourte A, Yon DK, Haro JM, Richette P, Beaudreuil J and Jacob L.
Publicada:
1 nov 2024
Ahead of Print:
19 nov 2024
Resumen:
Objective: There is a scarcity of data on the long-term relationship between cancer and chronic low back pain (CLBP). Therefore, this retrospective cohort study investigated the association between cancer and the 10-year incidence of CLBP in Germany. Methods: Data collected in 1293 German general practices between 2005 and 2022 were used for the study. Patients diagnosed with cancer were matched to those without cancer (1:1) using a propensity score based on age, sex, the mean number of consultations per year during the follow-up, index year, and several chronic conditions. The index date was the consultation corresponding to cancer diagnosis in the cancer group and a random visit date in the noncancer group. The analyses included Kaplan-Meier curves with the log-rank test and Cox regression models adjusted for other frequent conditions. Results: There were 203,657 adults in the cancer group and 203,657 adults in the noncancer group. The mean (SD) age was 66.2 (14.6) and 66.0 (13.8) years in patients with and without cancer, respectively, with a proportion of women of 51.3-51.8%. Within 10 years of the index date, 16.1% of people with cancer and 18.8% of those without cancer were diagnosed with CLBP (p-value < 0.001). The Cox regression analysis corroborated this finding, as there was a negative and significant association between cancer and CLBP (HR = 0.87, 95% CI = 0.86-0.89). Conclusions: Cancer was not associated with increased odds of CLBP in the decade following its diagnosis in Germany. Due to limitations inherent to the data, caution should be taken when interpreting the study results.
Filiaciones:
Kostev K:
Epidemiology, IQVIA, 60549 Frankfurt, Germany
University Clinic, Phillips-University, 35043 Marburg, Germany
Latourte A:
AP-HP, Université Paris Cité, Lariboisière Hospital, Department of Rheumatology, 75010 Paris, France
Université Paris Cité, Inserm U1132, Bioscar, 75010 Paris, France
Yon DK:
Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul 130-701, Republic of Korea
Department of Regulatory Science, Kyung Hee University, Seoul 130-701, Republic of Korea
Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul 130-701, Republic of Korea
Haro JM:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Dr. Antoni Pujadas, 42, 08830 Sant Boi de Llobregat, Barcelona, Spain
Richette P:
AP-HP, Université Paris Cité, Lariboisière Hospital, Department of Rheumatology, 75010 Paris, France
Université Paris Cité, Inserm U1132, Bioscar, 75010 Paris, France
Beaudreuil J:
Université Paris Cité, Inserm U1132, Bioscar, 75010 Paris, France
AP-HP, Université Paris Cité, Lariboisière-Fernand Widal Hospital, Department of Physical Medicine and Rehabilitation, 75010 Paris, France
Jacob L.:
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Dr. Antoni Pujadas, 42, 08830 Sant Boi de Llobregat, Barcelona, Spain
AP-HP, Université Paris Cité, Lariboisière-Fernand Widal Hospital, Department of Physical Medicine and Rehabilitation, 75010 Paris, France
Université Paris Cité, Inserm U1153, Epidemiology of Ageing and Neurodegenerative Diseases (EpiAgeing), 75010 Paris, France
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